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  • 1
    Online Resource
    Online Resource
    Image_2.JPEG
    Frontiers Media SA ; 2021
    In:  Frontiers in Earth Science Vol. 9 ( 2021-5-21)
    Details
    In: Frontiers in Earth Science, Frontiers Media SA, Vol. 9 ( 2021-5-21)
    Abstract: Studies of rainfall isotopic composition in the Iberian Peninsula are scarce, and to date, none of them have provided analyses of the triple oxygen isotopes, preventing from the complete understanding of current atmospheric processes in this region. We investigate the rainwater δ 17 O, δ 18 O, and δD and derived parameters 17 O-excess and d-excess in a mountain site in the Central South Pyrenees (Villanúa, Huesca, Spain) to identify the main factors (regional and local) controlling the isotopic composition of precipitation at event scale. The samples were collected on a rainfall-event basis during 2 years (from July 2017 to June 2019), and meteorological variables [temperature, relative humidity (RH), and rainfall amount] were monitored at the sampling site. The δ 17 O, δ 18 O, and δD values were higher during summer and lower during the rest of the year. In contrast, the 17 O-excess and d-excess were lower during summer and higher during the remaining months. We found that the isotopic parameters are weakly correlated with rainfall amount during each event, but they strongly depend on changes in air temperature and moderately on RH. We consider other factors affecting the isotopic composition of rainfall events that resulted to have an important role, such as the influence of the moisture source and trajectory throughout the variations in the synoptic pattern during rainfall events. This dataset can be useful for further comprehensive atmospheric and hydrological studies, with application to paleoclimatic investigations.
    Type of Medium: Online Resource
    ISSN: 2296-6463
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/feart.2021.633698
    DOI: 10.3389/feart.2021.633698.s001
    DOI: 10.3389/feart.2021.633698.s002
    DOI: 10.3389/feart.2021.633698.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2741235-0
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  • 2
    Online Resource
    Online Resource
    Table_5.XLSX
    Frontiers Media SA ; 2021
    In:  Frontiers in Microbiology Vol. 12 ( 2021-11-11)
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    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 12 ( 2021-11-11)
    Abstract: Glaciers and their microbiomes are exceptional witnesses of the environmental conditions from remote times. Climate change is threatening mountain glaciers, and especially those found in southern Europe, such as the Monte Perdido Glacier (northern Spain, Central Pyrenees). This study focuses on the reconstruction of the history of microbial communities over time. The microorganisms that inhabit the Monte Perdido Glacier were identified using high-throughput sequencing, and the microbial communities were compared along an altitudinal transect covering most of the preserved ice sequence in the glacier. The results showed that the glacial ice age gradient did shape the diversity of microbial populations, which presented large differences throughout the last 2000 years. Variations in microbial community diversity were influenced by glacial conditions over time (nutrient concentration, chemical composition, and ice age). Some groups were exclusively identified in the oldest samples as the bacterial phyla Fusobacteria and Calditrichaeota, or the eukaryotic class Rhodophyceae. Among groups only found in modern samples, the green sulfur bacteria (phylum Chlorobi) stood out, as well as the bacterial phylum Gemmatimonadetes and the eukaryotic class Tubulinea. A patent impact of human contamination was also observed on the glacier microbiome. The oldest samples, corresponding to the Roman Empire times, were influenced by the beginning of mining exploitation in the Pyrenean area, with the presence of metal-tolerant microorganisms. The most recent samples comprise 600-year-old ancient ice in which current communities are living.
    Type of Medium: Online Resource
    ISSN: 1664-302X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fmicb.2021.714537
    DOI: 10.3389/fmicb.2021.714537.s001
    DOI: 10.3389/fmicb.2021.714537.s002
    DOI: 10.3389/fmicb.2021.714537.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2587354-4
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  • 3
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    Table_4.XLSX
    Frontiers Media SA ; 2023
    In:  Frontiers in Microbiology Vol. 14 ( 2023-1-26)
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    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 14 ( 2023-1-26)
    Abstract: Over the last years, perennial ice deposits located within caves have awakened interest as places to study microbial communities since they represent unique cryospheric archives of climate change. Since the beginning of the twentieth century, the temperature has gradually increased, and it is estimated that by the end of this century the increase in average temperature could be around 4.0°C. In this context of global warming the ice deposits of the Pyrenean caves are undergoing a significant regression. Among this type of caves, that on the Cotiella Massif in the Southern Pyrenees is one of the southernmost studied in Europe. These types of caves house microbial communities which have so far been barely explored, and therefore their study is necessary. In this work, the microbial communities of the Pyrenean ice cave A294 were identified using metabarcoding techniques. In addition, research work was carried out to analyze how the age and composition of the ice affect the composition of the bacterial and microeukaryotic populations. Finally, the in vivo effect of climate change on the cellular machinery that allow microorganisms to live with increasing temperatures has been studied using proteomic techniques.
    Type of Medium: Online Resource
    ISSN: 1664-302X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fmicb.2023.1110091
    DOI: 10.3389/fmicb.2023.1110091.s001
    DOI: 10.3389/fmicb.2023.1110091.s002
    DOI: 10.3389/fmicb.2023.1110091.s003
    DOI: 10.3389/fmicb.2023.1110091.s004
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2587354-4
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  • 4
    Online Resource
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    Table_5.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Oncology Vol. 12 ( 2022-12-20)
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    In: Frontiers in Oncology, Frontiers Media SA, Vol. 12 ( 2022-12-20)
    Abstract: Evidence is scant regarding the long-term humoral and cellular responses Q7 triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines in cancer patients after repeated booster doses. The possibility of T-cell exhaustion following these booster doses in this population has not yet been fully studied and remains uncertain. Methods In this single-center prospective observational study, we explored the specific humoral and cellular response to S1 antigen in 36 patients with solid malignancies at baseline, and after the second and third doses of the mRNA-1273 vaccine. Results A dual behavior was observed: 24 (66.7%) patients showed partial specific IFN-γ response after the second dose that was further enhanced after the third dose; and 11 (30.5%) already showed an optimal response after the second dose and experienced a marked fall-off of specific IFN-γ production after the third (4 patients negativization), which might suggest T cell exhaustion due to repetitive priming to the same antigen. One (2.8%) patient had persistently negative responses after all three doses. Seroconversion occurred in all patients after the second dose. We then studied circulating exhausted CD8+ T-cells in 4 patients from each of the two response patterns, those with increase and those with decrease in cellular response after the third booster. The patients with decreased cellular response after the booster had a higher expression of PD1 + CD8 + and CD57 + PD1 + CD8 + exhausted T cells compared with those with an increased cellular response both in vivo and in vitro . The proportion of PD1 + CD8 + and CD57 + PD1 + CD8 + exhausted T cells inversely correlated with IFN-γ production. Discussion Our preliminary data show that the two-dose SARS-CoV-2 vaccine regimen was beneficial in all cancer patients of our study. An additional booster seems to be beneficial in suboptimal vaccine seroconverters, in contrast to maximal responders that might develop exhaustion. Our data should be interpreted with caution given the small sample size and highlight the urgent need to validate our results in other independent and larger cohorts. Altogether, our data support the relevance of immunological functional studies to personalize preventive and treatment decisions in cancer patients.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fonc.2022.975980
    DOI: 10.3389/fonc.2022.975980.s001
    DOI: 10.3389/fonc.2022.975980.s002
    DOI: 10.3389/fonc.2022.975980.s003
    DOI: 10.3389/fonc.2022.975980.s004
    DOI: 10.3389/fonc.2022.975980.s005
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2649216-7
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  • 5
    Online Resource
    Online Resource
    Usability and User Experience of Cognitive Intervention Technologies for Elderly People With MCI or Dementia: A Systematic Review
    Frontiers Media SA ; 2021
    In:  Frontiers in Psychology Vol. 12 ( 2021-4-22)
    Details
    In: Frontiers in Psychology, Frontiers Media SA, Vol. 12 ( 2021-4-22)
    Abstract: Incorporating technology in cognitive interventions represents an innovation, making them more accessible, flexible, and cost-effective. This will not be feasible without adequate user-technology fit. Bearing in mind the importance of developing cognitive interventions whose technology is appropriate for elderly people with cognitive impairment, the objective of this systematic review was to find evidence about usability and user experience (UX) measurements and features of stimulation, training, and cognitive rehabilitation technologies for older adults with mild cognitive impairment (MCI) or dementia. Method The Medline, PubMed, Scopus, ScienceDirect, and PsycINFO databases were searched for literature published in the last 10 years (2009–2019), and three researchers independently reviewed potentially eligible studies, following specific inclusion criteria. A systematic review of the studies was conducted, presenting a qualitative synthesis of usability and UX measures with their outcomes, study characteristics and features of the cognitive intervention technologies. Results Ten studies were selected: five were cognitive stimulation and five were cognitive training. Most of them (60%) were computer-based programs with a serious game format. Efficiency and effectiveness were the most frequent measurements used for collecting objective usability data, showing that elderly people with cognitive impairment require more time (45%) and help (40%) but can complete tasks (60%). Regarding UX or subjective usability data, questionnaires and scales were the most used methods, reporting positive experience despite certain difficulties with the interface in five studies. Conclusion Measuring usability and UX in cognitive intervention technologies for older adults with MCI or dementia provides an integrated view that can contribute to their development according to the needs and characteristics of the target population. More research is required to include this population group in usability and UX studies, as well as standardized tools and consensus on the relationship of these terms to guarantee the future effectiveness of cognitive intervention technologies. Review registration This review was registered in the PROSPERO (CRD42020158147) International Register of Systematic Review Protocols.
    Type of Medium: Online Resource
    ISSN: 1664-1078
    URL: Article
    DOI: 10.3389/fpsyg.2021.636116
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2563826-9
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