In:
Frontiers in Endocrinology, Frontiers Media SA, Vol. 11 ( 2020-11-19)
Abstract:
Cardiovascular autonomic neuropathy (CAN) is associated with diabetes mellitus , increasing morbidity and mortality. Some cross-sectional studies associated CAN with low 25-hydroxyvitamin D levels. The aim of our study was to evaluate the effect of high-dose vitamin D (VD) supplementation on CAN in Type 1 Diabetes Mellitus (T1DM) patients. Methods We performed a prospective study with 23 patients diagnosed with T1DM and CAN. Subjects with VD levels & lt;30 ng/ml received 10,000 IU/day; the ones with VD levels between 30–60 ng/ml were given 4,000 IU/day for 12 weeks. Results There was an improvement in CAN parameters related to resting heart rate variability, such as time domain parameters [Maximum RR interval (0.77 ± 0.11 vs 0.94 ± 0.51 s, p & lt;0.05), Mean length of regular RR intervals (0.71 ± 0.10 vs 0.76 ± 0.09 s, p & lt;0.05) and Standard deviation of all NN intervals (0.02 ± 0.01 vs 0.03 ± 0.02 s; p & lt;0.01)] and frequency domain parameters [Low Frequency (1.9 ± 0.5 vs 2.5 ± 0.9 s, p & lt; 0.001), Total Power (2.5 ± 0.4 vs 2.8 ± 0.6 s, p & lt;0.05)]. In addition, there was a correlation between absolute VD level variation and posttreatment High Frequency (%), as well as among percent variation in VD level and end-of-study Low Frequency/High Frequency ratio (r=0.6, p & lt;0.01; r= -0.5, p & lt;0.05, respectively). Conclusion Our pilot study is the first to suggest a strong association between high-dose vitamin D supplementation and improved cardiovascular autonomic neuropathy in T1DM patients. It occurred without any variation in HbA1C, blood pressure levels, lipids, and insulin dose. Clinical Trial Registration http://www.isrctn.com/ISRCTN32601947 , identifier ISRCTN32601947.
Type of Medium:
Online Resource
ISSN:
1664-2392
DOI:
10.3389/fendo.2020.605681
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2020
detail.hit.zdb_id:
2592084-4
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