In:
IUPHAR/BPS Guide to Pharmacology CITE, Edinburgh University Library, Vol. 2020, No. 3 ( 2020-06-19)
Abstract:
The mammalian genome encodes seven guanylyl cyclases, GC-A to GC-G, that are homodimeric transmembrane receptors activated by a diverse range of endogenous ligands. These enzymes convert guanosine-5'-triphosphate to the intracellular second messenger cyclic guanosine-3',5'-monophosphate (cyclic GMP). GC-A, GC-B and GC-C are expressed predominantly in the cardiovascular system, skeletal system and intestinal epithelium, respectively. GC-D and GC-G are found in the olfactory neuropepithelium and Grueneberg ganglion of rodents, respectively. GC-E and GC-F are expressed in retinal photoreceptors.
Type of Medium:
Online Resource
ISSN:
2633-1020
DOI:
10.2218/gtopdb/F1022/2020.3
Language:
Unknown
Publisher:
Edinburgh University Library
Publication Date:
2020
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