In:
IUPHAR/BPS Guide to Pharmacology CITE, Edinburgh University Library, Vol. 2023, No. 1 ( 2023-04-26)
Abstract:
Adhesion GPCRs are structurally identified on the basis of a large extracellular region, similar to the Class B GPCR, but which is linked to the 7TM region by a GPCR autoproteolysis-inducing (GAIN) domain [10] containing a GPCR proteolysis site (GPS). The N-terminal extracellular region often shares structural homology with adhesive domains (e.g. cadherins, immunolobulin, lectins) facilitating inter- and matricellular interactions and leading to the term adhesion GPCR [104, 418] . Several receptors have been suggested to function as mechanosensors [320, 288, 396, 38]. Cryo-EM structures of the 7-transmembrane domain of several adhesion GPCRs have been determined recently [292, 21, 403, 212, 300, 302, 431, 293] . The nomenclature of these receptors was revised in 2015 as recommended by NC-IUPHAR and the Adhesion GPCR Consortium [125].
Type of Medium:
Online Resource
ISSN:
2633-1020
DOI:
10.2218/gtopdb/F17/2023.1
Language:
Unknown
Publisher:
Edinburgh University Library
Publication Date:
2023
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