In:
The EMBO Journal, EMBO, Vol. 42, No. 12 ( 2023-06-15)
Abstract:
image New therapeutic targets are required for patients suffering from chronic obstructive pulmonary disease (COPD). Here, single CpG‐resolution DNA methylation maps of primary lung fibroblasts across disease stages reveal novel transcriptomic and epigenetic signatures associated with COPD onset and progression. DNA methylation and gene expression dynamics in lung fibroblasts from COPD patients were analyzed Aberrant methylation was observed at enhancer and promoter elements in COPD fibroblasts DNA methylation patterns are changed early in COPD fibroblasts Novel regulators of fibroblast proliferation and differentiation in COPD were identified
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.2022111272
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
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