In:
EMBO Molecular Medicine, EMBO, Vol. 8, No. 12 ( 2016-12), p. 1380-1389
Abstract:
image Early diagnosis is critical to improving lung cancer ( LC ) patient prognosis. An accurate, non‐invasive LC diagnostic test was developed based on expression analysis of embryonic vs. adult GATA 6 and NKX 2‐1 gene isoforms in exhaled breath condensates. Embryonic and adult isoforms of GATA 6 and NKX 2‐1 are differentially expressed during mouse lung development and in lung cancer. RNA purified from exhaled breath condensates ( EBC ) can be used for qRT – PCR ‐based expression analysis, despite the relatively high fragmentation of the isolated RNA . Embryonic and adult isoforms of GATA 6 and NKX 2‐1 detected in EBC can be combined into the LC score for LC diagnosis at stages I and II .
Type of Medium:
Online Resource
ISSN:
1757-4676
,
1757-4684
DOI:
10.15252/emmm.201606382
Language:
English
Publisher:
EMBO
Publication Date:
2016
detail.hit.zdb_id:
2485479-7
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