In:
The EMBO Journal, EMBO, Vol. 41, No. 23 ( 2022-12)
Abstract:
image Bacterial infection induces the formation of RIPosomes (RIPK2 oligomers) that are recruited to the bacteria to enhance the NF‐κB response. To maintain innate immune homeostasis, RIPosomes undergo selective autophagy mediated by autophagy proteins, IRGM, and p62/SQSTM1. RIPosomes are self‐assembling structures that are formed upon bacterial infection and coat bacteria to induce NF‐κB response. IRGM‐ and p62‐mediated selective autophagy degrades NODs, RIPK2, and RIPosomes to suppress NF‐κB response. IRGM suppresses RIPK2‐dependent NF‐κB and interferon responses upon Shigella ‐ and Salmonella infection. RIPK2 inhibition using GSK583 ameliorates shigellosis‐ and DSS‐induced gut inflammation in Irgm1KO mice
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.2022111289
Language:
English
Publisher:
EMBO
Publication Date:
2022
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
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