In:
EMBO reports, EMBO, Vol. 18, No. 8 ( 2017-08), p. 1412-1428
Abstract:
image Replication stress in telomeric DNA is resolved by a “looping‐out” mechanism, in which Topo II excises the stalled fork from the genome, NHEJ cyclizes cut DNA into t ‐circle‐tail structures, and broken telomeric DNA is re‐ligated. Replication stress induces the formation of extrachromosomal t ‐circle‐tail DNA , which resembles a cyclized leading or lagging strand during telomere replication. Inhibition of Topo II or NHEJ impairs t ‐circle‐tail formation, leading to accumulation of stalled replication forks at telomeres. Net loss of telomeric DNA caused by a looping‐out mechanism during resolving replication stress may accelerate replicative senescence and cell aging.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.201643866
Language:
English
Publisher:
EMBO
Publication Date:
2017
detail.hit.zdb_id:
2025376-X
SSG:
12
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