In:
EMBO reports, EMBO, Vol. 17, No. 11 ( 2016-11), p. 1624-1640
Abstract:
image The HOIP ubiquitin E3 ligase generates linear ubiquitin chains in mammals and is implicated in immune signaling. This study identifies Drosophila LUBEL as HOIP orthologue, which catalyzes the formation of linear ubiquitin chains in flies and has a role in heat shock response. LUBEL is the major ubiquitin E3 ligase that specifically catalyzes linear ubiquitin chains (M1) in flies. LUBEL is sufficient to catalyze linear ubiquitination via a RING / HECT hybrid mechanism. Catalytically dead LUBEL mutant adult flies show impaired heat shock response. dCYLD interacts with LUBEL to remove linear and K 63‐linked ubiquitin chains.
Type of Medium:
Online Resource
ISSN:
1469-221X
,
1469-3178
DOI:
10.15252/embr.201642378
Language:
English
Publisher:
EMBO
Publication Date:
2016
detail.hit.zdb_id:
2025376-X
SSG:
12
Permalink