In:
EMBO Molecular Medicine, EMBO, Vol. 6, No. 5 ( 2014-05), p. 662-684
Abstract:
image The transcriptional regulator MECP 2 is known to affect neurodevelopment. This study associates aggressive social behavior with MECP 2 genotype and expression changes in both male schizophrenic patients and mouse models of different genetic background. Mild (50%) overexpression of Mecp2 in mice influences male social aggression. The genetic background ( FVB /N versus C57Bl/6N) modulates this overexpression‐associated phenotype. Normal genetic variation of MECP 2 (single nucleotide polymorphisms) co‐determines the level of aggression in two independent cohorts of schizophrenic men. miR‐511 downregulates MECP 2 expression in T but not C carriers of SNP rs2734647, suggesting miR‐511 targeted therapies in MECP 2 gene duplication syndrome.
Type of Medium:
Online Resource
ISSN:
1757-4676
,
1757-4684
DOI:
10.1002/emmm.201303744
Language:
English
Publisher:
EMBO
Publication Date:
2014
detail.hit.zdb_id:
2485479-7
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