In:
The EMBO Journal, EMBO, Vol. 40, No. 4 ( 2021-02-15)
Abstract:
image The m 6 A RNA modification is enriched in the nervous system and its loss or dysregulation is known to affect neuronal development and function through incompletely understood mechanisms. Here, the Drosophila Ythdf is found as an m 6 A reader repressing translation of key neuronal targets of the fly Fragile X mental retardation RNA binding protein Fmr1, thereby modulating axonal growth. Loss‐of‐function mutants of N6‐methyltransferase Mettl3, Ythdf, or Fmr1, exhibit axonal overgrowth at the larval neuromuscular junction (NMJ) and in mushroom bodies (MB). Ythdf and Fmr1 are m 6 A reader proteins with different specificities, binding a common subset of m 6 A‐modified transcripts. Ythdf physically and genetically interacts with Fmr1, and recruits Fmr1 to certain m 6 A‐dependent binding sites. Ythdf and Fmr1 influence translation of specific targets in an m 6 A‐dependent manner.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.2020104975
Language:
English
Publisher:
EMBO
Publication Date:
2021
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
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