In:
The EMBO Journal, EMBO, Vol. 34, No. 22 ( 2015-11-12), p. 2804-2819
Abstract:
image Our study shows that cortical brain injury causes temporary environmental changes within the subventricular zone ( SVZ ) stem cell niche, resulting in an altered balance of the transcriptional regulators Id3 and E47 in neural stem/precursor cells ( NSPC s), leading to preferential differentiation of NSPC s into astrocytes. Traumatic brain injury results in increased BMP ‐2 abundance in the SVZ . Elevated BMP ‐2 levels are translated into a rapid increase in Id3 expression in adult NSPC subpopulations, specifically in Olig2 + C cells and Thbs4 + SVZ ‐born astrocytes. Id3 then heterodimerizes with the bHLH transcription factor E47 and releases E47‐mediated repression of astrocyte‐specific gene expression. Consequently, adult NSPC s preferentially differentiate into astrocytes and contribute to the cortical lesion astrocyte population.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.201591118
Language:
English
Publisher:
EMBO
Publication Date:
2015
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
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