In:
EMBO Molecular Medicine, EMBO, Vol. 7, No. 3 ( 2015-03), p. 339-356
Abstract:
image Flexibility in the N‐terminal octarepeat region of the prion protein affects endoproteolysis and disease pathology in transgenic mice. Beyond Creutzfeldt‐Jakob disease, the prion mechanism has implications for other misfolding diseases like Alzheimer's or Parkinson's disease. β‐cleavage of PrP was influenced by the octarepeat region using a mechanism independent from metal‐catalysed hydrolysis. Modulating the flexibility of the PrP octarepeat region uncoupled PrPSc levels from the onset of disease. The octarepeat region acts like a clutch to drive neurological disease.
Type of Medium:
Online Resource
ISSN:
1757-4676
,
1757-4684
DOI:
10.15252/emmm.201404588
Language:
English
Publisher:
EMBO
Publication Date:
2015
detail.hit.zdb_id:
2485479-7
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