In:
EMBO Molecular Medicine, EMBO, Vol. 9, No. 8 ( 2017-08), p. 1132-1149
Abstract:
image SPINK 2, a serine protease inhibitor, is believed to target the acrosin, the main sperm acrosomal protease. This study confirms SPINK 2 in that role and finds it essential for spermiogenesis as SPINK 2 deficiency induces a post meiotic block at the round spermatid stage leading to azoospermia in mice and men. In round spermatids, SPINK 2 is necessary to inactivate the acrosin during its transit through the endoplasmic reticulum and the Golgi apparatus. In the absence of SPINK 2, acrosin can auto‐activate, disorganize the Golgi apparatus, prevent the production of the acrosome and induce a block at the round spermatid stage. A reduced amount of SPINK 2 in heterozygotes is also deleterious, inducing a milder phenotype of oligozoospermia and/or teratozoospermia without a systematic infertility.
Type of Medium:
Online Resource
ISSN:
1757-4676
,
1757-4684
DOI:
10.15252/emmm.201607461
Language:
English
Publisher:
EMBO
Publication Date:
2017
detail.hit.zdb_id:
2485479-7
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