In:
The EMBO Journal, EMBO
Abstract:
image Mitochondria act as critical signaling hubs in cancer cells under hypoxic stress, but the molecular mechanisms involved remain poorly defined. This study identifies prolyl hydroxylase EglN1 (PHD2) as a mitochondrial oxygen sensor controlling AMPKα activation and cell metabolism under low oxygen conditions in mammary malignancies. EglN1 accumulates on mitochondria under hypoxia. EglN1 substrate‐binding β2β3 loop is required for mitochondrial translocation and breast cancer growth. EglN1 prolyl‐hydroxylates AMPKα on mitochondria. Hypoxia induces a EglN1‐CaMKK2‐AMPKα complex supporting AMPKα activation and cancer cell metabolism.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.2023113743
Language:
English
Publisher:
EMBO
Publication Date:
2023
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
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