In:
The EMBO Journal, EMBO, Vol. 36, No. 8 ( 2017-04-13), p. 1046-1065
Abstract:
image The chaperone HSP ‐60 binds and stabilizes SEK ‐1/ MAP kinase kinase to regulate p38 MAP kinase activity and anti‐bacterial immunity. Through a large‐scale genetic screen, sixteen mitochondrial components are identified as potential regulators of anti‐bacterial immunity in Caenorhabditis elegans . A fraction of HSP ‐60/mitochondrial chaperone is localized in the cytosol and enhances resistance against pathogenic bacteria, Pseudomonas aeruginosa . HSP ‐60 up‐regulates cytosolic PMK ‐1/p38 MAP kinase signaling through physically interacting with SEK ‐1/ MAP kinase kinase.
Type of Medium:
Online Resource
ISSN:
0261-4189
,
1460-2075
DOI:
10.15252/embj.201694781
Language:
English
Publisher:
EMBO
Publication Date:
2017
detail.hit.zdb_id:
1467419-1
detail.hit.zdb_id:
586044-1
SSG:
12
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