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  • ECO-Vector LLC  (2)
  • 1
    Online Resource
    Online Resource
    Analysis of association between vitamin D metabolite concentration in blood plasma and pancreatic cancer. Experience of one center
    ECO-Vector LLC ; 2023
    In:  Perm Medical Journal Vol. 40, No. 2 ( 2023-06-02), p. 11-21
    Details
    In: Perm Medical Journal, ECO-Vector LLC, Vol. 40, No. 2 ( 2023-06-02), p. 11-21
    Abstract: Introduction. An early detection of malignant neoplasms is of great practical importance for improvement of treatment results. Objective. To analyze the levels of dehydrocholecalciferol in patients with different forms of malignant neoplasms of the pancreas and chronic pancrestitis. Materials and methods. The cohort study enclosed the data from 160 patients, who were examined and treated in the Academician A.M. Granov Russian Scientific Center of Radiology and Surgical Technologies for the period from 2018 to 2022. The main group included 89 patients with morphologically confirmed diagnosis of the pancreatic cancer without metastases. The control group included 71 patient with the confirmed diagnosis of chronic pancreatitis. Vitamin D concentration was controlled prior to treatment. Results. The size of the tumor node with the location of pathological process in the head of the pancreas varied from 2.1 to 6.3 cm. In the subgroup of patients with tumor lesion of the head of the pancreas, decompression of biliary ducts due to mechanical jaundice was implemented in 43 (82.6 %) persons. When comparing the indicators of 25(ОН)D concentration, in 36 (69.2 %) patients of the main group, different degrees of fall of vitamin D concentration in blood plasma were found. Most often a pronounced deficit of vitamin D was diagnosed in patients with the tumor localized in the head of the pancreas (8 (15.9 % patients). Out of 37 patients with localization of the tumor node in the body/tail, 25 (67.5 %) persons demonstrated normal values of blood plasma vitamin D and 12 (13.4 %) different degrees of decrease in vitamin D concentration. A marked deficit of vitamin D was diagnosed in 2 (16.6 %) patients, deficit of vitamin D in 7 (58.3 %), insufficiency in 3 (25 %). In the control group, decrease in vitamin D level was determine in 12 (16.9 %) patients. An apparent deficit of vitamin D was diagnosed in 3 (4.2 %) patients, deficit of vitamin D in 4 (5.6 %), and insufficiency of vitamin D in 7 (9.8 %); normal values were registered in 57 (80.2 %) persons. Conclusions. Taking into account the obtained data regarding a reliable association between the deficit and insufficiency of vitamin D and the cancer of the head of the pancreas as well as literature data, it is worthwhile to use this indicator as a marker of early detection of pancreatic cancer in risk group patients.
    Type of Medium: Online Resource
    ISSN: 2687-1408 , 0136-1449
    URL: Article
    DOI: 10.17816/pmj40211-21
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2023
    Location Call Number Limitation Availability
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Fig. 6. The indicator of one-year mortality of patients suffering from malignant neoplasms of the pancreas registered in St. Petersburg medical organizations in dynamics from 2014 to 2019
    ECO-Vector LLC ; 2021
    In:  Bulletin of the Russian Military Medical Academy Vol. 23, No. 2 ( 2021-07-12), p. 155-164
    Details
    In: Bulletin of the Russian Military Medical Academy, ECO-Vector LLC, Vol. 23, No. 2 ( 2021-07-12), p. 155-164
    Abstract: Morbidity and mortality from pancreatic cancer is an urgent medical and social problem. Evaluation of statistical indicators in dynamics makes it possible to identify organizational and clinical problems in providing care to patients with malignant neoplasms of the pancreas. Medical and statistical indicators of incidence of malignant pancreatic neoplasms in St. Petersburg residents are evaluated. The assessment of medical and statistical indicators of the incidence of malignant neoplasms of the pancreas in residents of St. Petersburg. Statistical data were studied for the period from 2014 to 2019. The increase in the "rough" indicator of primary morbidity changed from 417.99 per 100 thousand population in 2014 to 505.6 in 2019. In the structure of primary cancer incidence, the indicator of active detection of pancreatic cancer glands in 2014 amounted to 3.6%, in 2019 3.8%. The proportion of patients with diagnoses confirmed morphologically increased from 48.9% to 61.4%. The proportion of patients with newly diagnosed stage IV of the disease changed from 39.5% in 2014 to 51.4% in 2019, and in patients with stage III in 2019 it was 33.3% (a decrease in comparison with 2014 15.3%). In 2019, the disease was diagnosed at stage II in 15.2% of patients. The proportion of patients with stage I in 2019 was 6.6%, this indicator in 2014 was registered at the level of 19.2%. From 2014 to 2019, the one-year mortality rate did not change and amounted to 67.9 and 67.4%, respectively (the decrease was 0.7%). Over the past 5 years, there has been no significant downward trend in the "rough" incidence and mortality rates from pancreatic cancer. However, in the dynamics, there was an increase in the number of patients registered for 5 or more years, and an increase in the accumulation index of the contingent of patients with pancreatic cancer.
    Type of Medium: Online Resource
    ISSN: 2687-1424 , 1682-7392
    URL: Issue
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.17816/brmma.232
    DOI: 10.17816/brmma60343
    DOI: 10.17816/brmma60343-41234
    DOI: 10.17816/brmma60343-41235
    DOI: 10.17816/brmma60343-41236
    DOI: 10.17816/brmma60343-41237
    DOI: 10.17816/brmma60343-41238
    DOI: 10.17816/brmma60343-41239
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2021
    Location Call Number Limitation Availability
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    Online Resource
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