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  • 1
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2022
    In:  Russian Journal of Physiotherapy, Balneology and Rehabilitation Vol. 20, No. 6 ( 2022-09-15), p. 551-558
    In: Russian Journal of Physiotherapy, Balneology and Rehabilitation, ECO-Vector LLC, Vol. 20, No. 6 ( 2022-09-15), p. 551-558
    Abstract: Cancer treatment with chemotherapy, targeted and immunotherapy is associated with a wide spectrum of dermatologic adverse events. Xerosis (dryness) of the skin is the most prevalent skin side effect in oncologic patients, which occurs both during treatment with "classic" chemotherapy drugs and modern cancer drugs, such as targeted therapy and immunotherapy. Despite the high prevalence of this side effect, current approaches to the correction of skin xerosis in cancer patients are very limited. At the same time, in the absence of adequate supportive treatment of xerosis, the formation of persistent fissures, eczematization and secondary infection is observed, which may lead to antitumor therapy regimen modification. Thus, optimization of prophylactic and treatment strategies for xerosis in patients treated with anticancer drugs remain an important interdisciplinary problem. Balneotherapy is a promising method for the correction of skin xerosis due to a complex positive effect on the level of skin hydration, a decrease in the intensity of inflammatory processes, a beneficial effect on the state of the skin barrier function, as well as an increase in antimicrobial protection. Available data on the use of balneotherapy in the supportive treatment of skin xerosis as a dermatological adverse event of anticancer therapy confirms the high efficacy and safety, as well as good tolerability of this method in cancer patients.
    Type of Medium: Online Resource
    ISSN: 2413-2969 , 1681-3456
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2022
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  • 2
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2023
    In:  Russian Journal of Skin and Venereal Diseases Vol. 25, No. 6 ( 2023-02-17), p. 41-53
    In: Russian Journal of Skin and Venereal Diseases, ECO-Vector LLC, Vol. 25, No. 6 ( 2023-02-17), p. 41-53
    Abstract: BACKGROUND: Paronychia and pyogenic granulomas occur in 1050% of patients treated with epidermal growth receptor (EGFR) inhibitors. Supportive therapy for periungual lesions is challenging, since these adverse reactions are prone to torpidity and frequent relapses. AIM: to evaluate the effectiveness of supportive treatment for paronychia and pyogenic granulomas ― dermatologic adverse events of EGFR inhibitors, with a combined cream with betamethasone dipropionate, clotrimazole, gentamicin, and betaxolol solution. MATERIALS AND METHODS: 16 patients with paronychia and pyogenic granulomas associated with EGFR inhibitor therapy were included in a 12-week open-label prospective study. Paronychia and pyogenic granulomas severity assessment was performed with the NCI-CTCAE v. 5.0, a developed 10-point scale. The intensity of pain was assessed with a visual-analogue scale (VAS). The quality of life was assessed with the Dermatology Life Quality Index (DLQI). RESULTS: A significant improvement of all parameters (p 0.05) was evaluated from week 1, indicating the effective reduction of dermatologic adverse event objective and subjective symptoms, improvement of patients quality of life. By the end of the study, 37.5% of patients had complete resolution of lesions, 62.5% of patients had minimal residual erythema. Decrease of pain sensation in the affected periungual folds was observed throughout the study (p 0.05). DLQI score indicated the "small effect" of paronychia and pyogenic granulomas on patients life by the end of the study. CONCLUSIONS: Supportive treatment of paronychia and pyogenic granulomas with a combined cream with betamethasone dipropionate, clotrimazole and gentamicin and a betaxolol 0.25% solution is effective in the management of paronychia and pyogenic granulomas objective and subjective symptoms, has a high tolerability, allows to improve patients quality of life and continue targeted therapy without dose reduction. Long-term maintenance of pain sensation after paronychia and pyogenic granulomas resolution underlines the need for additional treatment options that will improve the effectiveness of pain management.
    Type of Medium: Online Resource
    ISSN: 2412-9097 , 1560-9588
    URL: Issue
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2023
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  • 3
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2017
    In:  Russian Journal of Skin and Venereal Diseases Vol. 20, No. 5 ( 2017-12-15), p. 280-284
    In: Russian Journal of Skin and Venereal Diseases, ECO-Vector LLC, Vol. 20, No. 5 ( 2017-12-15), p. 280-284
    Abstract: To date one of the most discussed problems in the context of psoriasis is the possibility of correlation between the psoriatic process, considering its systemic nature, and the risk of cancer developing. Such interrelation can be caused both by systemic chronic inflammatory process and by methods of therapy. The purpose of this literature review is to assess the risk of developing malignant neoplasms of various organs and systems, as well as the factors that determine it, in patients with psoriasis in comparison with the general population. The mechanisms of action as well as early and remote side effects of the current treatment are described. The literature data on the risk of their carcinogenic effects are presented. The results of studies of a number of other factors acting as possible initiators of carcinogenesis in patients with psoriasis are highlighted, among them: the presence of a systemic inflammatory reaction, the severity and duration of the course of the disease, and also the comorbid states.
    Type of Medium: Online Resource
    ISSN: 2412-9097 , 1560-9588
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2017
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  • 4
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2022
    In:  Russian Journal of Physiotherapy, Balneology and Rehabilitation Vol. 21, No. 2 ( 2022-12-03), p. 131-141
    In: Russian Journal of Physiotherapy, Balneology and Rehabilitation, ECO-Vector LLC, Vol. 21, No. 2 ( 2022-12-03), p. 131-141
    Abstract: Supportive treatment plays an important role in oncology nowadays. The main aims of oncologic supportive treatment are management of cancer symptoms and adverse events of cancer treatment. In terms of dermatologic adverse events the most important types of reaction are oral mucositis during radiation therapy, chemotherapy and during hematopoetic stem cell transplantation, palmoplantar syndrome during chemotherapy, palmoplantar skin reaction, acneiform paronychia and pyogenic granulomas during targeted therapy, immune-related dermatologic adverse events during immunotherapy. During recent years, special attention has been paid to low level laser therapy for the prophylaxis and management of cancer therapy dermatologic adverse events. The effects of low level laser therapy may have a beneficial effect on many conditions that play important roles in the pathogenesis of radiation and chemotherapy-induced complications in oncologic patients. Therapeutic effects of low level laser therapy are attributed to the stimulation of adaptive processes and to the increase of nonspecific resistance. The latter develop due to the close interaction of the immune, humoral and nervous systems. When choosing a method for the supportive treatment of cancer therapy adverse events, it is extremely important to establish safety in terms of the tumor process and absence of negative effects on cancer treatment. Effects of low level laser therapy on the proliferative and invasive activity of an existing malignancy remains a matter of debate due to conflicting results from in vitro studies. At the same time, according to the results of numerous clinical studies, the use of this method is assumed to be safe for cancer patients.
    Type of Medium: Online Resource
    ISSN: 2413-2969 , 1681-3456
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2022
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  • 5
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2021
    In:  Russian Journal of Skin and Venereal Diseases Vol. 24, No. 3 ( 2021-06-15), p. 275-284
    In: Russian Journal of Skin and Venereal Diseases, ECO-Vector LLC, Vol. 24, No. 3 ( 2021-06-15), p. 275-284
    Abstract: BACKGROUND: Treatment of acne vulgaris remains an actual task of practical medicine. Despite the fact that the participation of severe acne in the structure of the morbidity of acne vulgaris is relatively small, precisely they most often leave behind scars, are accompanied by a pronounced cosmetic defect and significantly reduce the patients quality of life. Systemic treatment with isotretinoin is the gold standard of management of such patients, but this type of treatment is often accompanied by an exacerbation reaction, which negatively affects the general condition of the patient and reduces the compliance of treatment. AIM: To determine the effectiveness of the combined use of isotretinoin and a systemic corticosteroid in the treatment of severe forms of acne. MATERIALS AND METHODS: We observed 27 patients (16 men and 11 women) with severe or very severe grade on the IGA scale. All patients received combination therapy with isotretinoin (Sotret) at a dose of 0.5 mg/kg/day (cumulative dose from 120 to 150 mg/kg) for 8 months and prednisolone 30 mg/day 7 days, followed by dose reduction within a month. The assessment of treatment efficacy was based on the IGA scale, indicators DIA, DLQI and counting the number of inflammatory and non-inflammatory elements. RESULTS: During the 8 months of the study, 81.4% of patients achieved a 2-point reduction in the degree on the IGA scale (clear or almost clear skin). The DLQI index showed 74.9% improvement compared to the start of treatment. The average DIA values decreased by 72%. The reduction in the number of inflammatory and non-inflammatory elements showed a marked clinical improvement (91.4% for nodules and 98.3% for pustules). Exacerbations of acne were recorded in 18.5% of patients. CONCLUSIONS: Combined systemic treatment with isotretinoin and prednisolone for severe acne decreases the number of exacerbations and reduces the duration of treatment.
    Type of Medium: Online Resource
    ISSN: 2412-9097 , 1560-9588
    URL: Issue
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2021
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  • 6
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2019
    In:  Russian Journal of Physiotherapy, Balneology and Rehabilitation Vol. 18, No. 1 ( 2019-02-09), p. 17-22
    In: Russian Journal of Physiotherapy, Balneology and Rehabilitation, ECO-Vector LLC, Vol. 18, No. 1 ( 2019-02-09), p. 17-22
    Abstract: Materials and methods. 22 patients with fibromyalgia symptom complex were studied. The treatment proposed by the Protocol therapy skin triggers the back botulinum neurotoxin in very low doses. The results of the study revealed a pronounced clinical efficacy of Botulinum neurotoxin A on the daily functioning of patients and their psycho-emotional status: normalization of sleep, reduced fatigue, a marked reduction in psychovegetative disorders and the absence of pain manifestations, as well as a decrease in the tendency to edema.
    Type of Medium: Online Resource
    ISSN: 2413-2969 , 1681-3456
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2019
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  • 7
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2022
    In:  Russian Journal of Physiotherapy, Balneology and Rehabilitation Vol. 20, No. 4 ( 2022-07-04), p. 297-302
    In: Russian Journal of Physiotherapy, Balneology and Rehabilitation, ECO-Vector LLC, Vol. 20, No. 4 ( 2022-07-04), p. 297-302
    Abstract: BACKGROUND: Due to insufficient effectiveness of currently known methods of treatment of patients with scleroatrophic lichenes of the vulva, as well as the lack of reasonable ways to manage patients at the stage of rehabilitation, there is a need to search for new approaches to solve this problem. AIMS: to study the possibility to apply electrophoresis of the enzyme preparation from hydrobiont collagenases at the stage of rehabilitation of women with scleroatrophic lichenes of the vulva. MATERIAL AND METHODS: In a group of 86 female patients with scleroatrophic lichenes of the vulva (mean age 4913 years) a comparative assessment of the efficacy of traditional approach to scleroatrophic lichenes of the vulva treatment and staged treatment using electrophoresis of the enzyme preparation at the stage of rehabilitation was carried out. RESULTS: The developed approach to the treatment of patients with scleroatrophic lichenes of the vulva with application of electrophoresis of the enzyme complex after stabilization of the cutaneous process by glucocorticosteroids at the rehabilitation stage effectively reduces severity and activity of cutaneous manifestations of scleroatrophic lichenes of the vulva that was reflected in the index (LS-A) from 22, the index (LS-A) from 22.704.71 to 7.451.90 and the dermatological quality of life index (DIQL) from 22.774.86 to 4.951.10, in comparison with the patients in the control group, where the conventional therapy was conducted, where the LS-A index showed dynamics from 19.674.34 to 12.693.35, and the DIQL significant differences between the groups by 16 weeks of follow-up (p 0.001). CONCLUSION: During staged treatment, a more pronounced and long-lasting effect is observed in the group of patients with electrophoresis of the enzyme complex during the rehabilitation stage as compared to the group with emollients.
    Type of Medium: Online Resource
    ISSN: 2413-2969 , 1681-3456
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2022
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  • 8
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2022
    In:  Russian Journal of Physiotherapy, Balneology and Rehabilitation Vol. 21, No. 4 ( 2022-12-06), p. 245-254
    In: Russian Journal of Physiotherapy, Balneology and Rehabilitation, ECO-Vector LLC, Vol. 21, No. 4 ( 2022-12-06), p. 245-254
    Abstract: BACKGROUND: Taking into account the role of angiogenesis processes in the zone of development of immature scar tissue, it seems pathogenetically justified to use a vascular laser for the correction of hypertrophic skin scars that are at the maturation stage. In this regard, we used a pulsed dye laser, the effect of which is perceived by the patient without pronounced pain, and the technology itself is quite safe and leads to a rapid recovery of the skin after the procedure. Fermencol phonophoresis supplementation of laser therapy with pulsed dye laser has the potential to enhance the therapeutic efficacy of a vascular laser, since Fermenkol is a preparation of collagenases of hydrobiont origin that can destroy the components of the extracellular matrix, the formation of which exceeds in intensity its degradation by matrix metalloproteinases at the stage of formation scar. The use of ultrasound in this case not only accelerates the delivery of proteolytic enzymes, but also exhibits independent fibromodulatory activity. AIM: comparative evaluation of the effectiveness of the use of physiotherapeutic factors (Fermenkol phonophoresis, pulsed dye laser therapy and their combination) in patients with immature hypertrophic skin scars, taking into account clinical research methods. MATERIAL AND METHODS: The study was performed on 125 patients aged 19 to 50 years with immature (less than 6 months) hypertrophic skin scars. All patients were divided into 4 groups according to the simple fixed randomization procedure. The first group (control, 32 patients) received course local compression therapy using silicone plates for two months. The second group (31 patients) was treated with phonophoresis of 0.01% Fermencol gel. The third group (31 patients) was treated with pulsed dye laser. The fourth group (31 patients) received complex treatment, including a combination of two pulsed dye laser procedures and two cycles of Fermencol phonophoresis. Patients were examined twice: before the start of treatment and 2 weeks after the end of the course of treatment. The assessment of the clinical condition of patients was carried out according to the modified Vancouver scale for assessing the signs of cicatricial deformity. RESULTS: Conducting a course of treatment of patients with immature hypertrophic skin scars made it possible to establish a good tolerability of the effects of physiotherapeutic factors. At the same time, the positive dynamics of clinical manifestations of cicatricial changes in the skin, assessed by Vancouver scar scale, in the control and main groups was not the same and increased in the following order: Control Fermencol phonophoresis pulsed dye laser pulsed dye laser + Fermencol phonophoresis. The use of the correlation adaptometry technique, which makes it possible to objectify the obtained clinical data, evaluating them using the category of functional reserves of the body, confirmed that the best clinical result was achieved in the group recieved combined use of pulsed dye laser and Fermencol phonophoresis. CONCLUSION: The conclusion was made about the maximum therapeutic effect in the group of complex use of pulsed dye laser and ultrasound administration of an enzyme preparation, which manifested itself due to the synergistic type of interaction between two physiotherapeutic factors that have different modalities, points of application and mechanisms for implementing their therapeutic activity.
    Type of Medium: Online Resource
    ISSN: 2413-2969 , 1681-3456
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2022
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  • 9
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2020
    In:  Russian Journal of Skin and Venereal Diseases Vol. 23, No. 6 ( 2020-12-15), p. 432-442
    In: Russian Journal of Skin and Venereal Diseases, ECO-Vector LLC, Vol. 23, No. 6 ( 2020-12-15), p. 432-442
    Abstract: therapy for their reliable removal. Standard methods of treatment often give unpredictable results, are accompanied by various complications, and require the use of expensive equipment. AIM: To investigate the efficacy and safety of intralesional injection of a combination of 5-fluorouracil (5-FU) and betamethasone for the treatment of keloids and hypertrophic scars. MATERIALS AND METHODS: The study involved 26 patients who were divided into two equal groups. Patients in group A received intralesional injections of betamethasone, and those in group B received 5-FU and betamethasone. Three injections were performed with an interval of 3 weeks. The scars were assessed at the beginning of the treatment, on the 3rd and 6th week during the treatment, and 4 and 16 weeks after the end of the treatment. The dynamics of scar condition was evaluated by the average decrease in the scar height and density, changes in subjective sensations, and the presence or absence of complications. RESULTS: At 4 weeks after the end of the therapy, the total effectiveness of reducing the initial scar height was significantly higher in group B (10 patients; 76.9%) than in group A (6; 46.1%). In the comparison of long-term results at 16 weeks after treatment, 92.3% of the patients from group B and 53.8% of the patients from group A showed cessation of scar growth, flattening and softening, diminished itching and pain, smoothing of the scar contour, and a decrease in the color of the border between the scar and surrounding tissues. CONCLUSIONS: The combination of betamethasone with 5-FU is safer and more effective than monotherapy with betamethasone or 5-FU in the treatment of keloid and hypertrophic scars, with a faster and more pronounced decrease in the height and density of the scar, erythema, and subjective sensations. This mode of therapy is characterized by a low relapse rate with prolonged follow-up. The article is of interest to practicing cosmetologists, dermatologists, and plastic surgeons.
    Type of Medium: Online Resource
    ISSN: 2412-9097 , 1560-9588
    URL: Issue
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2020
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  • 10
    Online Resource
    Online Resource
    ECO-Vector LLC ; 2023
    In:  Russian Journal of Skin and Venereal Diseases Vol. 26, No. 1 ( 2023-04-07), p. 13-24
    In: Russian Journal of Skin and Venereal Diseases, ECO-Vector LLC, Vol. 26, No. 1 ( 2023-04-07), p. 13-24
    Abstract: BACKGROUND: On average, within 7 years from the debut of skin psoriasis, patients may develop psoriatic arthritis, characterized by a chronic, relapsing progressive course. Early manifestations of psoriatic arthritis may be axial lesions presenting with inflammatory back pain. Currently, many experts are raising the topic of early prescription of genetically engineered biological drugs for axial lesions in order to prevent disability. Members of the GRAPPA expert group (Group for Research and Assessment of Psoriasis and Psoriatic Arthritis) currently do not provide specific recommendations for the treatment of axial lesions in psoriatic arthritis. The most commonly used regimens are those for axial spondyloarthritis and ankylosing spondylitis. There are also no treatment regimens for early manifestations of axial lesions in patients with smooth skin psoriasis without an established diagnosis of psoriatic arthritis. All regimens consider axial lesions in patients who have already been diagnosed with psoriatic arthritis. Thus, it is necessary to form interdisciplinary standardized protocols for the management of such patients. AIM: to investigate the efficacy and safety of IL-17 inhibitors in axial lesions in patients with skin psoriasis. MATERIALS AND METHODS: A prospective non-interventional comparative multicenter study was conducted in parallel groups of patients with smooth skin psoriasis (n=87). To study the effectiveness of the developed method of therapy, the formation of comparison groups is provided. 3 variants of therapy were analyzed: IL-17A inhibitors (n=21; group 1, main); methotrexate (n=35; group 2, comparison); standard desensitizing therapy was used in group 3 (n=31; control). The distribution into groups was carried out taking into account the severity, prevalence of the skin process (according to PASI, BSA), the quality of life of the patient (according to DLQI), the patient's wishes and the patient's ability to purchase genetically engineered biological drugs. RESULTS: According to our results, the use of IL-17A inhibitors shows high efficiency: by week 52, 100% of patients reached the level of PASI 75, 90.5% ― PASI 90 and 85.7% ― PASI 100, NAPSI 100 (Nail Psoriasis Severity Index) was observed in 71.4% patients. All patients reported a reduction of pain at 12, 24 and 52 weeks with a mean BASDAI of 5.9 (SD=2.3), 4.1 (SD=1.3), and 2.7 (SD=0.9), respectively. It was found that 90.5% of patients achieved ACR 20 by the end of the study at week 52. The majority of patients (85.7%) achieved remission or low DAPSA disease activity after 24 weeks of therapy. The mean ASDAS at 12, 24, 52 weeks was 3.07 (0.9), 2.2 (1.0), and 2.3 (0.9), respectively. CONCLUSIONS: Thus, in patients with skin psoriasis and axial lesions, it is recommended to make the earlier prescription of biologic treatment from the group of IL-17 inhibitors in order to prevent the development of severe forms of psoriatic arthritis and human disability.
    Type of Medium: Online Resource
    ISSN: 2412-9097 , 1560-9588
    URL: Issue
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2023
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