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  • 1
    Online Resource
    Online Resource
    Changes in Metabolic Parameters of Rats in Different Age Periods After Prenatal Stress
    ECO-Vector LLC ; 2022
    In:  I.P. Pavlov Russian Medical Biological Herald Vol. 30, No. 4 ( 2022-12-28), p. 471-480
    Details
    In: I.P. Pavlov Russian Medical Biological Herald, ECO-Vector LLC, Vol. 30, No. 4 ( 2022-12-28), p. 471-480
    Abstract: INTRODUCTION: Currently, biomedical specialists give special attention to studying the influence of stressogenic factors on an organism of a pregnant woman, the embryonic development of the fetus and the subsequent development of offspring in the early and late ontogenesis. It has been found in a number of studies that prenatal stress can lead to reduction of physical activity and hormonal disorders. The factors leading to disorders in regulation of immune and metabolic homeostasis have been identified. Despite considerable interest in the study of the consequences of prenatal stress, its impact on changes in metabolic intensity in different periods of postnatal ontogenesis in animals of different genders has not been sufficiently studied. AIM: To study parameters of metabolism intensity in different age periods of postnatal ontogenesis in rats offspring of both genders after intrauterine stress load. MATERIALS AND METHODS: Stress load was modeled in daily forced swimming of pregnant rats at 1012C for 5 min. Oxygen consumption, carbon dioxide excretion (ml/h/kg), and heat exchange (kcal/h/kg) in male and female rats were determined using a Phenomaster automated modular unit (TSE Systems GmbH, Germany) on the 21st, 30th and 60th day of the ontogenesis. Statistical significance of differences between the studied parameters was assessed using Mann-Whitney U-test for independent groups. RESULTS: The study parameters of intact animals practically did not differ in the suckling (the 21st day) and infantile period (the 30th day), but significantly decreased in the juvenile period of development (the 60th day). It was found that the intrauterine stress did not lead to statistically significant changes in the absolute values of metabolic parameters as compared to the control, but affected the period of appearance of age-related variations of these parameters in male rats. In these animals, the volumes of oxygen consumption, carbon dioxide excretion, and the level of heat radiation reduced as early as in the infantile period (as compared to 21-day-old rats) and reached the minimum level by the 60th day of the postnatal ontogenesis. In female rats subjected to intrauterine stress, changes in the study parameters in different periods of life were similar to those of intact animals. CONCLUSION: Therefore, prenatal stress modeled by swimming of female parents in cold water, has a modulating effect on age-related dynamics of metabolic parameters of male rats, which was manifested by the decrease in these parameters in the earlier period of development.
    Type of Medium: Online Resource
    ISSN: 2500-2546 , 0204-3475
    URL: Issue
    URL: Article
    DOI: 10.17816/PAVLOVJ.304
    DOI: 10.17816/PAVLOVJ106532
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2022
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  • 2
    Online Resource
    Online Resource
    Comparative analysis of the paravertebral block and epidural anesthesia in the complex of anesthetic support for laparoscopic kidney surgery: open randomized clinical study
    ECO-Vector LLC ; 2023
    In:  Regional Anesthesia and Acute Pain Management Vol. 17, No. 1 ( 2023-04-19), p. 25-38
    Details
    In: Regional Anesthesia and Acute Pain Management, ECO-Vector LLC, Vol. 17, No. 1 ( 2023-04-19), p. 25-38
    Abstract: BACKGROUND: Laparoscopic kidney surgery is performed mostly under general anesthesia. Regional techniques, primarily epidural anesthesia / analgesia (EA), help improve the surgical results. However, EA is often accompanied by several complications and side effects. The thoracic paravertebral block (PVB) is considered a reasonable and effective alternative. OBJECTIVE: To conduct a comparative analysis of the effectiveness of general anesthesia (GA) + PVB, GA alone, and GA + EA in laparoscopic kidney surgery. MATERIALS AND METHODS: An open-label randomized clinical study enrolled 180 patients who underwent laparoscopic kidney surgery. By using an online tool (https//www resource.studyrandomizer.com), the patients were divided into three groups in a 1:1:1 ratio. Group 1 (n=60) underwent surgery under GA + PVB, group 2 (n=60) under GA, and group 3 under GA + EA. In each group, the intra-, and postoperative need for opioids, pain intensity on a visual analog scale (VAS) 1, 6, 12, and 24 h after surgery, and activation time were assessed. The results of the groups were compared. The frequency and nature of complications when performing and working with PVB were studied. RESULTS: The intraoperative need for opioids was greater in the GA group and comparable in the GA + PVB and GA + EA groups (p=0.137). The postoperative pain in the PVB group remained consistently low (VAS score 2 points) during the observation period. In the GA group, it reached 5 points after 1, 6, and 12 h and 4 points 24 h after the surgery; in the EA group, it was 4 points (1, 6, and 12 h) and 3 points 24 h after the surgery. The prolonged PVB in the postoperative period significantly lowered the opioid need (p=0.045) and contributed to earlier activation of the patients (p=0.001). Under ultrasound control, PVB is safe, and effective. CONCLUSION: The study showed that PVB in the complex of anesthetic support for kidney surgery provides an effective and safe anesthesia / analgesia and can be used as an alternative to EA.
    Type of Medium: Online Resource
    ISSN: 2687-1394 , 1993-6508
    URL: Article
    DOI: 10.17816/RA217696
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2023
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  • 3
    Online Resource
    Online Resource
    Рис. 2. Сводные результаты по дозиметрии плода при исследованиях органов грудной клетки (работы под руководством А.В. Водоватова [8] и J. Gu [13]) и брюшной полости (работы под руководством А. Kelaranta [14] и Е. Angel [15]) с моделированием линии регрессии LOESS и 95% доверительного интервала.
    ECO-Vector LLC ; 2023
    In:  Digital Diagnostics Vol. 4, No. 2 ( 2023-07-12), p. 170-184
    Details
    In: Digital Diagnostics, ECO-Vector LLC, Vol. 4, No. 2 ( 2023-07-12), p. 170-184
    Abstract: BACKGROUND: Currently, no systematic data are available on fetal radiation exposure as a result of radiographic studies during pregnancy. Consequently, there are no approved methods of its calculation that can be used in clinical practice. It is especially relevant for computed tomography scans as it is a widely used and highly informative method of diagnostic imaging associated with high exposure levels. AIM: to systematize currently available data on radiation dose absorbed by the fetus from computed tomography scans in pregnant women. MATERIALS AND METHODS: The search for publications in Russian and English was conducted in PubMed/Medline, Google Scholar and еLibrary. The final analysis included 12 papers including 8 studies using human body phantoms, 3 retrospective studies and one prospective clinical study. RESULTS: Abdominal and pelvic computed tomography scans as well as whole-body scans were found to be associated with the highest fetal radiation exposure. However, in none of the publications the fetal exposure limit was exceeded. CONCLUSION: Clinically indicated non-contrast-enhanced computed tomography scans in pregnant women are not likely to be associated with the fetal absorbed doses that exceed the limit of 100 mGy regardless of the scanned area. However, this limit might be exceeded in case of performing multiple studies or if multiphase abdominal or pelvic computed tomography scans, or whole-body computed tomography scans are performed in patients with multiple trauma. In these cases, a decision regarding the need for these investigations should be made by a multi-disciplinary team (including radiation safety specialists, diagnostic radiologists and clinicians) based on the results of additional risk assessment.
    Type of Medium: Online Resource
    ISSN: 2712-8962 , 2712-8490
    URL: Issue
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.17816/DD.42
    DOI: 10.17816/DD472150
    DOI: 10.17816/DD472150-3489311
    DOI: 10.17816/DD472150-3489312
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2023
    detail.hit.zdb_id: 3076615-1
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  • 4
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    Online Resource
    Safety study of fentanyl and dexmedetomidine combination in an experimental model of respiratory failure
    ECO-Vector LLC ; 2016
    In:  Reviews on Clinical Pharmacology and Drug Therapy Vol. 14, No. 3 ( 2016-09-15), p. 53-57
    Details
    In: Reviews on Clinical Pharmacology and Drug Therapy, ECO-Vector LLC, Vol. 14, No. 3 ( 2016-09-15), p. 53-57
    Abstract: In an experimental model of respiratory failure induced by a single intraperitoneal injection of 1 LD50 of paraquat (24 mg/kg) the changes of physical activity tolerance, respiratory function parameters were studied and histomorphologic validation of experimental results was confirmed. In a model of respiratory failure the assessment of analgesic activity and toxicity of fentanyl, dexmedetomidine and their combination was made and compared with intact animals. The integral tolerance rates (therapeutic action width) were also estimated. It was shown that on the background of pulmonary pathology for each of the drugs 13-28% decrease of average lethal doses was observed. At the same time when administered in combination an average effective dose of the drugs wasn’t changed in contrast with single-drug analgesia.
    Type of Medium: Online Resource
    ISSN: 2542-1875 , 1683-4100
    URL: Issue
    URL: Article
    DOI: 10.17816/RCF143
    DOI: 10.17816/RCF14353-57
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2016
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  • 5
    Online Resource
    Online Resource
    Possibilities of using paravertebral blockade in laparoscopic kidney surgery
    ECO-Vector LLC ; 2022
    In:  Regional Anesthesia and Acute Pain Management Vol. 16, No. 1 ( 2022-07-20), p. 23-31
    Details
    In: Regional Anesthesia and Acute Pain Management, ECO-Vector LLC, Vol. 16, No. 1 ( 2022-07-20), p. 23-31
    Abstract: A main goal of modern anesthesiology is to reduce the bodys stress response to surgical aggression. This needs a multidisciplinary approach: surgeons reduce the invasiveness of surgery, and anesthesiologists use a multimodal approach in the intraoperative and postoperative periods. They combine general anesthesia with epidural anesthesia (EA), which has not only undeniable and proven advantages but also several disadvantages. An interesting alternative is paravertebral block (PVB), a compromise between neuroaxial (EA) and peripheral nerve block. PVB provides analgesic efficacy comparable to that of EA, but with significantly fewer complications and side effects. Many studies have described the widespread and successful use of PVB in thoracic surgery and endoscopic urology. However, the literature on the use of PVB in laparoscopic renal surgery anesthesia is extremely scarce. Thus, large multicenter studies are needed to determine the place of PVB in the anesthetic management of laparoscopic renal surgery.
    Type of Medium: Online Resource
    ISSN: 2687-1394 , 1993-6508
    URL: Article
    DOI: 10.17816/1993-6508-2022-16-1-23-31
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2022
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