In:
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Computers, Materials and Continua (Tech Science Press), Vol. 25, No. 6 ( 2017-07-05), p. 913-921
Abstract:
Long noncoding RNA (lncRNA) colon cancer-associated transcript 2 (CCAT2) has been demonstrated to play an important role in diverse tumorigenesis. However, the biological function of lncRNAs in glioma is still unknown. In this study, we found that lncRNA CCAT2 was overexpressed in glioma
tissues and cell lines and associated with tumor grade and size. Furthermore, patients with high levels of lncRNA CCAT2 had poorer survival than those with lower levels of lncRNA CCAT2. Knocking down lncRNA CCAT2 expression significantly suppressed the glioma cell growth, migration, and invasion, as well as induced early apoptosis of glioma cells in vitro. Moreover, lncRNA CCAT2 regulated epithelial‐mesenchymal transition (EMT)-associated gene expression. In conclusion, lncRNA CCAT2 plays an important role in glioma tumorigenesis and progression and may act as a potential biomarker
for therapeutic strategy and prognostic prediction.
Type of Medium:
Online Resource
ISSN:
0965-0407
DOI:
10.3727/096504016X14792098307036
Language:
English
Publisher:
Computers, Materials and Continua (Tech Science Press)
Publication Date:
2017
detail.hit.zdb_id:
1114699-0
detail.hit.zdb_id:
2044620-2
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