In:
Journal of Pharmaceutical Technology, Research and Management, Chitkara University Publications, Vol. 6, No. 2 ( 2018-11-02), p. 135-141
Abstract:
Axitinib is a tyrosine kinase Inhibiter. In a commenced analysis, a effortless and responsive high-performance liquid-chromatography method was developed and validated for the quantitative estimation of Axitinib in bulk and in-house tablet dosage form. The present method was developed and validated using LC-GC Qualisil BDS C18 (250 mm × 4.6 mm, 5 μm). The separation of Axitinib was employed using a methanol: water 85:15% v/vas a mobile phase at optimal flow rate 1 mL/min and column oven temperature 30°C. While, Axitinib was examined at 330 nm with a photo diode array detector; retention timewas found to be 3.23 min.The intended method was validated by ICH rules for the accuracy, precision, sensitivity, and ruggedness. The linearity was followed in the concentration range of 4 – 24 μg/ mL as demonstrated by correlation coefficient (r2) of 0.9994. The robustness of proposed method was assessed by purposelyvarying the chromatographic conditions. Consequently, the intended method can routinely be subjected for th estimation of Axitinib in bulk and in tablets formulation.
Type of Medium:
Online Resource
ISSN:
2321-2217
,
2321-2225
Uniform Title:
Exploring RP-HPLC Method for analysis of Axitinib in Bulk and in-house Tablets
DOI:
10.15415/jptrm.2018.62
DOI:
10.15415/jptrm.2018.62010
Language:
Unknown
Publisher:
Chitkara University Publications
Publication Date:
2018
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