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  • 1
    Keywords: Mine water. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (194 pages)
    Edition: 1st ed.
    ISBN: 9783030401160
    Series Statement: Springer Theses Series
    DDC: 622.5
    Language: English
    Note: Intro -- Supervisor's Foreword -- Parts of this thesis have been published in the following journal articles: -- This research was supported by the following projects: -- Contents -- Executive Summary -- 1 Introduction -- 1.1 Research Background and Significance -- 1.2 Current Research Status -- 1.2.1 Research on Water-Bearing and Water-resisting Properties of the TOL in NCCs -- 1.2.2 Pertinent Research on Grouting Reconstruction of the TOL -- 1.3 Major Limitations of Current Research -- 1.4 Research Content and Technical Approach -- 1.4.1 Research Content -- 1.4.2 Research Method and Technical Approach -- References -- 2 Paleosedimentary Environments and Karst Characteristics of Ordovician Limestone in North China Coalfields -- 2.1 Paleotectonic Movement in NCCs -- 2.2 Evolution of the Paleosedimentary Environments in NCCs -- 2.3 Characteristics of Karst Development of Ordovician Limestone in NCCs -- References -- 3 Water-Bearing and Water-resisting Properties of Top of Ordovician Limestone in North China Coalfields -- 3.1 Research on Planar Division of Water Yield Property of TOL in NCCs -- 3.1.1 Analysis on the Influencing Factors of Water Abundance of the TOL -- 3.1.2 Comprehensive Evaluation Method of Water Abundance of the TOL -- 3.1.3 Case Study of Water Abundance of the TOL -- 3.2 Research on Vertical Zonation of Water-Bearing and Water-resisting Properties of the TOL in NCCs -- 3.2.1 Three Vertical Zones in the TOL -- 3.2.2 Case Study of Vertical Zoning of Water-Bearing and Water-resisting Properties of the TOL -- References -- 4 Utilizability of Weathered and Filled Zone of Top of Ordovician Limestone in North China Coalfields -- 4.1 Formation, Evolution, and Spatial Distribution Characteristics of the Weathered and Filled Zone of the TOL -- 4.2 Experimental Study on the Utilizability of the Weathered and Filled Zone of TOL as Aquifuge. , 4.2.1 Rock Strength Test -- 4.2.2 Rock Permeability Test -- 4.2.3 Water-resisting Capacity and Rock Strength Test of TOL -- 4.3 Utilizability of the Weathered and Filled Zone of the TOL as Aquifuge -- References -- 5 Criterion for Utilization and Grouting Reconstruction of Top of Ordovician Limestone -- 5.1 Criterion for Utilization and Grouting Reconstruction of the TOL -- 5.2 Thickness of Grouting Reconstruction of the TOL -- 5.3 Prediction Methods of Damage Depth in Coal Seam Floor -- References -- 6 Technical System of Grouting Reconstruction of Top of Ordovician Limestone -- 6.1 Experimental Study on Grouting Material Formula Using Pulverized Coal Ash -- 6.2 Dispersion Properties of Grout in Karst Fractures of the TOL -- 6.3 Surface Automatic Grouting System Using Fly Ash-Based Grouting Materials -- References -- 7 Case Study of Utilization and Grouting Reconstruction of Top of Ordovician Limestone -- 7.1 Background of Tested Working Face 3105 in Sangshuping Coal Mine, Hancheng Mining Area -- 7.2 Karst Characteristics and Water Yield Properties of TOL in Sangshuping Coal Mine -- 7.3 Utilization of the TOL in Working Face 3105 -- Reference -- 8 Conclusions and Innovation Points -- 8.1 Conclusions -- 8.2 Innovation Points.
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  • 2
    Online Resource
    Online Resource
    Cham :Springer International Publishing AG,
    Keywords: Mine water-Prevention. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (521 pages)
    Edition: 1st ed.
    ISBN: 9783030670597
    Series Statement: Professional Practice in Earth Sciences Series
    DDC: 622.5
    Language: English
    Note: Intro -- Preface -- Contents -- 1 Water Hazards in Coal Mines and Their Classifications -- 1.1 Introduction -- 1.2 Water Inrush Conceptual Site Models for Coal Mines of China -- 1.2.1 Development of Water Inrush Conceptual Site Models -- 1.2.2 Benefits of Water Inrush Conceptual Site Models -- 1.3 Classification of Water Inrush for Coal Mines of China -- 1.3.1 Principles for Classification of Mine Water Inrush -- 1.3.2 Types of Mine Water Inrush -- 1.3.3 Characteristics of Mine Water Inrushes -- 1.4 Hydrogeological Classification for Mine Water Hazard Control -- 1.4.1 Criteria of Hydrogeological Classification -- 1.4.2 Hydrogeological Classification of Coal Mines in China -- 1.4.3 Hydrogeological Characteristics of Mines -- 1.5 Advances in Prevention and Control Technologies of Mine Water Hazards -- 1.5.1 Updated Mining Principles -- 1.5.2 Evolution of Water Inrush Coefficient -- 1.5.3 Supplemental Investigation and Water Inrush Prediction -- 1.5.4 Advanced Detection and Dewatering Technologies -- 1.5.5 Early Warning Technique -- 1.5.6 Innovated Grouting Technique -- References -- 2 Mine Water Inrush Mechanisms and Prediction Methods -- 2.1 Overview of Water Inrush Studies -- 2.2 Water Inrush Mechanisms in North China's Coalfields -- 2.2.1 Hydrogeological Background -- 2.2.2 Relationship Between Aquiclude Thickness and Groundwater Pressure -- 2.2.3 Impact of Mining Activities on Geologic Barrier -- 2.2.4 Laboratory Experiments on Failure of Geologic Barrier -- 2.2.5 Initial Conductive Zone in Geologic Barrier -- 2.2.6 In-Situ Hydrofracturing Tests -- 2.3 Water Inrush Mechanism Through Karst Collapse Columns -- 2.3.1 Karst Collapse Columns and Their Relationship with Mining -- 2.3.2 Hydrogeological Characteristics of Karst Collapse Columns -- 2.3.3 Water Inrushes Through Karst Collapse Columns -- 2.4 Prediction Methods. , 2.4.1 Water Inrush Coefficient Method -- 2.4.2 Vulnerability Index Method -- 2.4.3 Three-Map and Two-Prediction Method -- 2.4.4 Five-Map and Two-Coefficient Method -- References -- 3 Modeling of Groundwater Flow in Karst Aquifers for Mine Water Control -- 3.1 Inputs to Karst Hydrogeological Systems -- 3.1.1 Discharge-Storage Method -- 3.1.2 Recession-Curve-Displacement Method -- 3.1.3 Meteorological Model -- 3.2 Groundwater Flow in Karst Hydrogeological Systems -- 3.2.1 Groundwater Flow Patterns in Karst Aquifers -- 3.2.2 Influenced Flow Patterns -- 3.2.3 Confluent Flow in Karst Aquifers -- 3.2.4 Siphon Karst Flow -- 3.3 Water Budget Analyses -- 3.3.1 Discharge Hydrograph -- 3.3.2 Discharge Recession Analysis -- 3.3.3 Discharge Chemograph -- 3.3.4 Groundwater Level Hydrograph -- 3.4 Statistical and Stochastic Methods -- 3.4.1 Regression Analysis -- 3.4.2 Kernel Analysis -- 3.4.3 Threshold Autoregressive Analysis -- 3.5 Mixing-Cell Models -- 3.5.1 Discrete-State-Compartment Model -- 3.5.2 Water Tank Models -- 3.6 Physics-Based Models -- 3.6.1 Equivalent-Porous-Medium Models -- 3.6.2 Discrete-Fracture Models -- 3.6.3 Double-Continuum Models -- 3.6.4 Determination of Hydraulic Parameters at Respective Scales -- 3.7 Quantitative Analysis of Tracer Tests -- 3.7.1 Tracer-Breakthrough Curves -- 3.7.2 Estimation of Hydraulic Parameters of Karst Conduits -- 3.7.3 Evaluation of Dynamic Dispersion in Karst Aquifers -- 3.8 Application of Dual-Porosity Model to Groundwater Simulation in the Ordovician Limestone in Jiaozuo Coalfield, China -- 3.8.1 Introduction to Jiaozuo Coalfield -- 3.8.2 Karst Conduit Distribution -- 3.8.3 Calibration of the Dual-Porosity Model -- References -- 4 Prevention and Control of Mine Water Hazards from Underlying Aquifers. , 4.1 Water Prevention and Control Technology in Mining Lower Coal Seams Under Potentiometric Pressure in Xingtai Dongpang Mine -- 4.1.1 Mine Background -- 4.1.2 Application of Water Prevention and Control Technology to Mining Under Potentiometric Pressure -- 4.2 Grouting Technology in Thin-Bedded Limestone to Prevent Water Inrushes from Underlying Aquifers in Zhuzhuang Coal Mine of Huaibei Coalfield -- 4.2.1 Background -- 4.2.2 Large-Scale Advance Grouting Technology in Transforming Limestone into Water Barrier -- 4.3 Utilization of the Top of the Ordovician Limestone in the Sangshuping Mine of Hancheng and the Underground Grouting Transformation Technology -- 4.3.1 Mine Background -- 4.3.2 Utilization of Top of the Ordovician Limestone and Underground Grouting Transformation Technology -- 4.4 Emergency Mitigation Technology of Water Inrush Induced Mine Flooding in Luotuoshan Coal Mine in Wuhai Energy Co., Ltd. -- 4.4.1 Overview -- 4.4.2 Emergency Water-Plugging Technology in #16 Coal Seam Air Return Lane -- 4.4.3 Comprehensive Investigation Technology of Water Inrush Point -- 4.5 Characterization and Remediation of Karst Collapse Columns in Renlou Coal Mine, China -- 4.5.1 Mine Background -- 4.5.2 Water Source Discrimination by Temperature and Hardness Measurements -- 4.5.3 Geophysical Investigations -- 4.5.4 Borehole Exploration and Grouting -- 4.5.5 Summary -- 4.6 Design and Construction of Watertight Plugs in Permeable Karst Collapse Columns in Restoration of Flooded Dongpang Mine, China -- 4.6.1 Mine Background -- 4.6.2 Construction of the Watertight Plug -- 4.6.3 Completion Criteria of Grouting -- 4.6.4 Grout Intake Distribution -- 4.6.5 Evaluation of Plug Effectiveness -- 4.6.6 Summary -- 4.7 Utilization of Paleokarst Crust of Ordovician Limestone in Water Inrush Control in Sihe Coal Mine, Shanxi Province. , 4.7.1 Introduction to Paleokarst Crust -- 4.7.2 Characteristics of Paleokarst Crust at Sihe Mine -- 4.7.3 Hydrogeogical Properties of Fengfeng Formation -- 4.7.4 Thickness of Aquifuge in Fengfeng Formation -- 4.7.5 Summary -- 5 Prevention and Control of Mine Water Hazards from Overlying Aquifers -- 5.1 Water Control Technology for Overlying Thick-Bedded Sandstone Fissure Aquifer in Hujiahe Mine, Binchang, Shaanxi -- 5.1.1 Mine Background -- 5.1.2 Exploration and Prevention Techniques for Water Hazards Posed by the Overlying Thick Sandstone Fissure Aquifer -- 5.1.3 Exploration and Prevention Technologies of Water Hazards from Overlying Thick Sandstone Fissure Aquifers -- 5.2 Prevention and Control Technology for Water Disaster from Bed-Separation Voids of Overlying Formations in Hongliu Coal Mine, Ningdong Coalfield -- 5.2.1 Mine Background -- 5.2.2 Investigation and Mitigation of Bed-Separation Water Inrush -- 5.2.3 Summary of Bed-Separation Groundwater Control -- 5.3 Prevention Technology on Water and Sand Inrush in Halagou Coal Mine, Shendong Coalfield -- 5.3.1 Mine Background -- 5.3.2 Mechanism and Conditions of Water and Sand Inrush -- 5.3.3 Prevention and Control Technology of Water and Sand Inrush -- 6 Investigation and Prevention of Water Hazards from Old Mine Pools in Ordos -- 6.1 Background of Mining Area -- 6.2 Technical Approaches -- 6.3 Geophysical Methods -- 6.3.1 High-Density Electrical Resistivity Imaging -- 6.3.2 Transient Electromagnetic Method -- 6.3.3 Shallow Seismic Method -- 6.3.4 EH4 Magnetotelluric Method -- 6.3.5 Control-Source Audio Magnetotelluric Method -- 6.3.6 Magnetic Method -- 6.4 Achievements by Electrical and Magnetic Imaging -- 6.4.1 Geophysical Survey Layout -- 6.4.2 Results of Electrical Resistivity Imaging Survey -- 6.4.3 Results of Transient Electromagnetic Survey -- 6.4.4 Results of Magnetic Survey. , 6.5 Experience with Reconnaissance of Coal Mine Goafs in Ordos -- 6.5.1 Unified Organization and Implementation Led by Government -- 6.5.2 Reliance on Technical Institutions to Improve Reconnaissance Effectiveness -- 6.5.3 Active Cooperation of Coal Mine Enterprises -- 6.5.4 Concerted Efforts from All Parties -- 7 Technologies in Sealing Massive Karst Conduits in Restoration of a Flooded Open Pit Quarry in West Virginia, United States -- 7.1 Mine Background -- 7.2 Water Source and Pathway Investigations -- 7.3 Concept of Remediation Design -- 7.3.1 Selection of Cut off Methodology -- 7.3.2 Selection of Grouting Concepts -- 7.3.3 Evolution of the Remediation Program -- 7.4 Execution of Mitigation -- 7.4.1 Drilling -- 7.4.2 Grouting -- 7.5 Drilling and Grouting Quantities -- 7.6 Impact of Grouting Program on Quarry Inflow Characteristics -- 7.7 Summary -- References -- 8 Environmental Impact Assessment in Hongliulin Coal Mine -- 8.1 Mine Background Setting -- 8.1.1 Geographical Location -- 8.1.2 Mining History -- 8.1.3 Resources and Reserves -- 8.2 Geoenvironmental Background -- 8.2.1 Physical Geography -- 8.2.2 Topography -- 8.2.3 Stratum Lithology and Geological Structure -- 8.2.4 Aquifer and Aquiclude -- 8.2.5 Groundwater Flow, Recharge, and Discharge -- 8.2.6 Analysis of Groundwater Recharge Conditions in the Mine -- 8.2.7 Geotechnical Conditions -- 8.2.8 Characteristics of Coal Seam -- 8.2.9 Other Human Engineering Activities in the Mine and its Vicinity -- 8.3 Geoenvironmental Impact Assessment -- 8.3.1 Evaluation Scope and Level -- 8.3.2 Assessment of Background Conditions -- 8.3.3 Soil Erosion Intensity -- 8.3.4 Vegetation and Coverage -- 8.3.5 Summary -- 8.4 Predictive Geoenvironmental Assessment -- 8.4.1 Predictive Assessment of Geological Disasters -- 8.4.2 Predictive Assessment of Aquifers. , 8.4.3 Evaluation of Impact on Topography and Landscape.
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  • 3
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    Federica Eduati; Lara M Mangravite; Tao Wang; Hao Tang; J Christopher Bare; Ruili Huang; Thea Norman; Mike Kellen; Michael P Menden; Jichen Yang; Xiaowei Zhan; Rui Zhong; Guanghua Xiao; Menghang Xia; Nour Abdo; Oksana Kosyk; Federica Eduati; Lara M Mangravite; J Christopher Bare; Thea Norman; Mike Kellen; Michael P Menden; Stephen Friend; Gustavo Stolovitzky; Allen Dearry; Raymond R Tice; Ruili Huang; Menghang Xia; Anton Simeonov; Nour Abdo; Oksana Kosyk; Ivan Rusyn; Fred A Wright; Tao Wang; Hao Tang; Xiaowei Zhan; Jichen Yang; Rui Zhong; Guanghua Xiao; Yang Xie; Hao Tang; Jichen Yang; Tao Wang; Guanghua Xiao; Yang Xie; Salvatore Alaimo; Alicia Amadoz; Muhammad Ammad-ud-din; Chloé-Agathe Azencott; Jaume Bacardit; Pelham Barron; Elsa Bernard; Andreas Beyer; Shao Bin; Alena van Bömmel; Karsten Borgwardt; April M Brys; Brian Caffrey; Jeffrey Chang; Jungsoo Chang; Eleni G Christodoulou; Mathieu Clément-Ziza; Trevor Cohen; Marianne Cowherd; Sofie Demeyer; Joaquin Dopazo; Joel D Elhard; Andre O Falcao; Alfredo Ferro; David A Friedenberg; Rosalba Giugno; Yunguo Gong; Jenni W Gorospe; Courtney A Granville; Dominik Grimm; Matthias Heinig; Rosa D Hernansaiz; Sepp Hochreiter; Liang-Chin Huang; Matthew Huska; Yunlong Jiao; Günter Klambauer; Michael Kuhn; Miron Bartosz Kursa; Rintu Kutum; Nicola Lazzarini; Inhan Lee; Michael K K Leung; Weng Khong Lim; Charlie Liu; Felipe Llinares López; Alessandro Mammana; Andreas Mayr; Tom Michoel; Misael MongiovìJonathan D Moore; Ravi Narasimhan; Stephen O Opiyo; Gaurav Pandey; Andrea L Peabody; Juliane Perner; Alfredo Pulvirenti; Konrad Rawlik; Susanne Reinhardt; Carol G Riffle; Douglas Ruderfer; Aaron J Sander; Richard S Savage; Erwan Scornet; Patricia Sebastian-Leon; Roded Sharan; Carl Johann Simon-Gabriel; Veronique Stoven; Jingchun Sun; Hao Tang; Ana L Teixeira; Albert Tenesa; Jean-Philippe Vert; Martin Vingron; Tao Wang; Thomas Walter; Sean Whalen; Zofia Wiśniewska; Yonghui Wu; Guanghua Xiao; Yang Xie; Hua Xu; Jichen Yang; Xiaowei Zhan; Shihua Zhang; Junfei Zhao; W Jim Zheng; Rui Zhong; Dai Ziwei; Stephen Friend; Allen Dearry; Anton Simeonov; Raymond R Tice; Ivan Rusyn; Fred A Wright; Gustavo Stolovitzky; Yang Xie; Julio Saez-Rodriguez
    Nature Publishing Group (NPG)
    Publication Date: 2015-09-09
    Description: Nature Biotechnology 33, 933 (2015). doi:10.1038/nbt.3299 Authors: Federica Eduati, Lara M Mangravite, Tao Wang, Hao Tang, J Christopher Bare, Ruili Huang, Thea Norman, Mike Kellen, Michael P Menden, Jichen Yang, Xiaowei Zhan, Rui Zhong, Guanghua Xiao, Menghang Xia, Nour Abdo, Oksana Kosyk, Federica Eduati, Lara M Mangravite, J Christopher Bare, Thea Norman, Mike Kellen, Michael P Menden, Stephen Friend, Gustavo Stolovitzky, Allen Dearry, Raymond R Tice, Ruili Huang, Menghang Xia, Anton Simeonov, Nour Abdo, Oksana Kosyk, Ivan Rusyn, Fred A Wright, Tao Wang, Hao Tang, Xiaowei Zhan, Jichen Yang, Rui Zhong, Guanghua Xiao, Yang Xie, Hao Tang, Jichen Yang, Tao Wang, Guanghua Xiao, Yang Xie, Salvatore Alaimo, Alicia Amadoz, Muhammad Ammad-ud-din, Chloé-Agathe Azencott, Jaume Bacardit, Pelham Barron, Elsa Bernard, Andreas Beyer, Shao Bin, Alena van Bömmel, Karsten Borgwardt, April M Brys, Brian Caffrey, Jeffrey Chang, Jungsoo Chang, Eleni G Christodoulou, Mathieu Clément-Ziza, Trevor Cohen, Marianne Cowherd, Sofie Demeyer, Joaquin Dopazo, Joel D Elhard, Andre O Falcao, Alfredo Ferro, David A Friedenberg, Rosalba Giugno, Yunguo Gong, Jenni W Gorospe, Courtney A Granville, Dominik Grimm, Matthias Heinig, Rosa D Hernansaiz, Sepp Hochreiter, Liang-Chin Huang, Matthew Huska, Yunlong Jiao, Günter Klambauer, Michael Kuhn, Miron Bartosz Kursa, Rintu Kutum, Nicola Lazzarini, Inhan Lee, Michael K K Leung, Weng Khong Lim, Charlie Liu, Felipe Llinares López, Alessandro Mammana, Andreas Mayr, Tom Michoel, Misael Mongiovì, Jonathan D Moore, Ravi Narasimhan, Stephen O Opiyo, Gaurav Pandey, Andrea L Peabody, Juliane Perner, Alfredo Pulvirenti, Konrad Rawlik, Susanne Reinhardt, Carol G Riffle, Douglas Ruderfer, Aaron J Sander, Richard S Savage, Erwan Scornet, Patricia Sebastian-Leon, Roded Sharan, Carl Johann Simon-Gabriel, Veronique Stoven, Jingchun Sun, Hao Tang, Ana L Teixeira, Albert Tenesa, Jean-Philippe Vert, Martin Vingron, Tao Wang, Thomas Walter, Sean Whalen, Zofia Wiśniewska, Yonghui Wu, Guanghua Xiao, Yang Xie, Hua Xu, Jichen Yang, Xiaowei Zhan, Shihua Zhang, Junfei Zhao, W Jim Zheng, Rui Zhong, Dai Ziwei, Stephen Friend, Allen Dearry, Anton Simeonov, Raymond R Tice, Ivan Rusyn, Fred A Wright, Gustavo Stolovitzky, Yang Xie & Julio Saez-Rodriguez
    Print ISSN: 1087-0156
    Electronic ISSN: 1546-1696
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
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  • 4
    Publication Date: 2013-06-04
    Description: Nature Cell Biology 15, 700 (2013). doi:10.1038/ncb2748 Authors: Tao Wang, Hao Wu, Yujing Li, Keith E. Szulwach, Li Lin, Xuekun Li, I-Ping Chen, Ian S. Goldlust, Stormy J. Chamberlain, Ann Dodd, He Gong, Gene Ananiev, Ji Woong Han, Young-sup Yoon, M. Katharine Rudd, Miao Yu, Chun-Xiao Song, Chuan He, Qiang Chang, Stephen T. Warren & Peng Jin
    Print ISSN: 1465-7392
    Electronic ISSN: 1476-4679
    Topics: Biology , Medicine
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  • 5
    Publication Date: 2013-08-02
    Description: EMBO Reports 14, 733 (2013). doi:10.1038/embor.2013.86 Authors: Ting Li, Qiuhe Lu, Guolun Wang, Hao Xu, Huanwei Huang, Tao Cai, Biao Kan, Jianning Ge & Feng Shao Transcription of rRNA genes (rDNAs) in the nucleolus is regulated by epigenetic chromatin modifications including histone H3 lysine (de)methylation. Here we show that LegAS4, a Legionella pneumophila type IV secretion system (TFSS) effector, is targeted to specific rDNA chromatin regions in the host nucleolus.
    Keywords: SET domainnucleolusrDNA transcriptionHP1Legionella pneumophila
    Print ISSN: 1469-221X
    Electronic ISSN: 1469-3178
    Topics: Biology , Medicine
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  • 6
    Publication Date: 2015-01-29
    Description: Synthetic biologists have developed DNA/molecular modules that perform genetic logic operations in living cells to track key moments in a cell's life or change the fate of a cell. Increasing evidence has also revealed that diverse genetic logic gates capable of generating a Boolean function play critically important roles in synthetic biology. Basic genetic logic gates have been designed to combine biological science with digital logic. SynBioLGDB (http://bioinformatics.ac.cn/synbiolgdb/) aims to provide the synthetic biology community with a useful resource for efficient browsing and visualization of genetic logic gates. The current version of SynBioLGDB documents more than 189 genetic logic gates with experimental evidence involving 80 AND gates and 16 NOR gates, etc. in three species (Human, Escherichia coli and Bacillus clausii). SynBioLGDB provides a user-friendly interface through which conveniently to query and browse detailed information about these genetic logic gates. SynBioLGDB will enable more comprehensive understanding of the connection of genetic logic gates to execute complex cellular functions in living cells. Scientific Reports 5 doi: 10.1038/srep08090
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 7
    Publication Date: 2015-01-14
    Description: Article Performing radio-frequency arbitrary waveform generation in the optical domain offers advantages over electronic-based methods but suffers from lack of integration and slow speed. Here, Wang et al . propose a fast-reconfigurable, radio-frequency arbitrary waveform generator fully integrated in a silicon chip. Nature Communications doi: 10.1038/ncomms6957 Authors: Jian Wang, Hao Shen, Li Fan, Rui Wu, Ben Niu, Leo T. Varghese, Yi Xuan, Daniel E. Leaird, Xi Wang, Fuwan Gan, Andrew M. Weiner, Minghao Qi
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 8
    Publication Date: 2015-02-17
    Description: Members of the inositol phosphate metabolism pathway regulate cell proliferation, migration and phosphatidylinositol-3-kinase (PI3K)/Akt signaling, and are frequently dysregulated in cancer. Whether germline genetic variants in inositol phosphate metabolism pathway are associated with cancer risk remains to be clarified. We examined the association between inositol phosphate metabolism pathway genes and risk of eight types of cancer using data from genome-wide association studies. Logistic regression models were applied to evaluate SNP-level associations. Gene- and pathway-based associations were tested using the permutation-based adaptive rank-truncated product method. The overall inositol phosphate metabolism pathway was significantly associated with risk of lung cancer (P = 2.00 × 10−4), esophageal squamous cell carcinoma (P = 5.70 × 10−3), gastric cancer (P = 3.03 × 10−2) and renal cell carcinoma (P = 1.26 × 10−2), but not with pancreatic cancer (P = 1.40 × 10−1), breast cancer (P = 3.03 × 10−1), prostate cancer (P = 4.51 × 10−1), and bladder cancer (P = 6.30 × 10−1). Our results provide a link between inherited variation in the overall inositol phosphate metabolism pathway and several individual genes and cancer. Further studies will be needed to validate these positive findings, and to explore its mechanisms. Scientific Reports 5 doi: 10.1038/srep08473
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 9
    Publication Date: 2015-04-01
    Description: The film bulk acoustic resonator (FBAR) is a widely-used MEMS device which can be used as a filter, or as a gravimetric sensor for biochemical or physical sensing. Current device architectures require the use of an acoustic mirror or a freestanding membrane and are fabricated as discrete components. A new architecture is demonstrated which permits fabrication and integration of FBARs on arbitrary substrates. Wave confinement is achieved by fabricating the resonator on a polyimide support layer. Results show when the polymer thickness is greater than a critical value, d, the FBARs have similar performance to devices using alternative architectures. For ZnO FBARs operating at 1.3–2.2 GHz, d is ~9 μm, and the devices have a Q-factor of 470, comparable to 493 for the membrane architecture devices. The polymer support makes the resonators insensitive to the underlying substrate. Yields over 95% have been achieved on roughened silicon, copper and glass. Scientific Reports 5 doi: 10.1038/srep09510
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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  • 10
    Publication Date: 2015-04-25
    Description: Memory effect of electric-field control on magnetic behavior in magnetoelectric composite heterostructures has been a topic of interest for a long time. Although the piezostrain and its transfer across the interface of ferroelectric/ferromagnetic films are known to be important in realizing magnetoelectric coupling, the underlying mechanism for nonvolatile modulation of magnetic behaviors remains a challenge. Here, we report on the electric-field control of magnetic properties in wide-band (011)-Pr0.7Sr0.3MnO3/0.7Pb(Mg1/3Nb2/3)O3-0.3PbTiO3 heterostructures. By introducing an electric-field-induced in-plane anisotropic strain field during the cooling process from room temperature, we observe an in-plane anisotropic, nonvolatile modulation of magnetic properties in a wide-band Pr0.7Sr0.3MnO3 film at low temperatures. We attribute this anisotropic memory effect to the preferential seeding and growth of ferromagnetic (FM) domains under the anisotropic strain field. In addition, we find that the anisotropic, nonvolatile modulation of magnetic properties gradually diminishes as the temperature approaches FM transition, indicating that the nonvolatile memory effect is temperature dependent. By taking into account the competition between thermal energy and the potential barrier of the metastable magnetic state induced by the anisotropic strain field, this distinct memory effect is well explained, which provides a promising approach for designing novel electric-writing magnetic memories. Scientific Reports 5 doi: 10.1038/srep09668
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
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