GLORIA

GEOMAR Library Ocean Research Information Access

X

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
Filter
  • Cambridge University Press (CUP)  (14)
Materialart
Verlag/Herausgeber
  • Cambridge University Press (CUP)  (14)
Person/Organisation
Sprache
Erscheinungszeitraum
  • 1
    Online-Ressource
    Online-Ressource
    Heritability and Whole Genome Linkage of Pulse Pressure in Chinese Twin Pairs
    Cambridge University Press (CUP) ; 2012
    In:  Twin Research and Human Genetics Vol. 15, No. 6 ( 2012-12), p. 759-766
    Details
    In: Twin Research and Human Genetics, Cambridge University Press (CUP), Vol. 15, No. 6 ( 2012-12), p. 759-766
    Kurzfassung: Elevated pulse pressure is associated with cardiovascular disorders and mortality in various populations. The genetic influence on pulse pressure has been confirmed by heritability estimates using related individuals. Recently, efforts have been made in mapping genes that are linked to the phenotype. We report results on our heritability and linkage study conducted on the Chinese population in mainland China where cardiovascular and cerebrovascular diseases are becoming the leading cause of death. A total of 630 pairs of middle-aged Chinese twins were collected for heritability analysis, from which 63 dizygotic twin pairs were randomly selected for genome-wide linkage analysis using Affymetrix 6.0 SNP array. Regression analysis reconfirmed the significant effects of age, sex, and BMI on pulse pressure. Comparison of twin models suggested the parsimonious AE model as the best model with a heritability estimate of 0.45. Genome-wide non-parametric linkage analysis identified three significant linkage peaks on chromosome 11 (lod score 4.06 at 30.5 cM), chromosome 12 (lod score 3.97 at 100.7 cM), and chromosome 18 (lod score 4.01 at 70.7 cM) with the last two peaks closely overlapping with linkage peaks reported by two American studies. In addition, multiple regions with suggestive linkage were identified with many of them overlapping with published linkage regions. Our results provide both epidemiological and molecular genetic evidence for the genetic dissection of pulse pressure in the Chinese population, which could help in fine mapping and in characterizing genes that are involved in the regulation of pulse pressure.
    Materialart: Online-Ressource
    ISSN: 1832-4274 , 1839-2628
    URL: Article
    DOI: 10.1017/thg.2012.58
    Sprache: Englisch
    Verlag: Cambridge University Press (CUP)
    Publikationsdatum: 2012
    ZDB Id: 2184274-7
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 2
    Online-Ressource
    Online-Ressource
    The Qingdao Twin Registry: A Status Update
    Cambridge University Press (CUP) ; 2013
    In:  Twin Research and Human Genetics Vol. 16, No. 1 ( 2013-02), p. 79-85
    Details
    In: Twin Research and Human Genetics, Cambridge University Press (CUP), Vol. 16, No. 1 ( 2013-02), p. 79-85
    Kurzfassung: In 1998, the Qingdao Twin Registry was initiated as the main part of the Chinese National Twin Registry. By 2005, a total of 10,655 twin pairs had been recruited. Since then new twin cohorts have been sampled, with one longitudinal cohort of adolescent twins selected to explore determinants of metabolic disorders and health behaviors during puberty and young adulthood. Adult twins have been sampled for studying heritability of multiple phenotypes associated with metabolic disorders. In addition, an elderly twin cohort has been recruited with a focus on genetic studies of aging-related phenotypes using twin modeling and genome-wide association analysis. Cross-cultural collaborative studies have been carried out between China, Denmark, Finland, and US cohorts. Ongoing data collection and analysis for the Qingdao Twin Registry will be discussed in this article.
    Materialart: Online-Ressource
    ISSN: 1832-4274 , 1839-2628
    URL: Article
    DOI: 10.1017/thg.2012.113
    Sprache: Englisch
    Verlag: Cambridge University Press (CUP)
    Publikationsdatum: 2013
    ZDB Id: 2184274-7
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 3
    Online-Ressource
    Online-Ressource
    The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits
    Cambridge University Press (CUP) ; 2015
    In:  Twin Research and Human Genetics Vol. 18, No. 4 ( 2015-08), p. 348-360
    Details
    In: Twin Research and Human Genetics, Cambridge University Press (CUP), Vol. 18, No. 4 ( 2015-08), p. 348-360
    Kurzfassung: For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m 2 ) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.
    Materialart: Online-Ressource
    ISSN: 1832-4274 , 1839-2628
    URL: Article
    DOI: 10.1017/thg.2015.29
    Sprache: Englisch
    Verlag: Cambridge University Press (CUP)
    Publikationsdatum: 2015
    ZDB Id: 2184274-7
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 4
    Online-Ressource
    Online-Ressource
    Genetic and Environmental Influences on Pulmonary Function and Muscle Strength: The Chinese Twin Study of Aging
    Cambridge University Press (CUP) ; 2017
    In:  Twin Research and Human Genetics Vol. 20, No. 1 ( 2017-02), p. 53-59
    Details
    In: Twin Research and Human Genetics, Cambridge University Press (CUP), Vol. 20, No. 1 ( 2017-02), p. 53-59
    Kurzfassung: Genetic and environmental influences on predictors of decline in daily functioning, including forced expiratory volume in 1 s (FEV 1 ), forced vital capacity (FVC), handgrip, and five-times-sit-to-stand test (FTSST), have not been addressed in the aging Chinese population. We performed classical twin modeling on FEV 1 , FVC, handgrip, and FTSST in 379 twin pairs (240 MZ and 139 DZ) with median age of 50 years (40–80 years). Data were analyzed by fitting univariate and bivariate twin models to estimate the genetic and environmental influences on these measures of physical function. Heritability was moderate for FEV 1 , handgrip, and FTSST (55–60%) but insignificant for FVC. Only FVC showed moderate control, with shared environmental factors accounting for about 50% of the total variance. In contrast, all measures of pulmonary function and muscle strength showed modest influences from the unique environment (40–50%). Bivariate analysis showed highly positive genetic correlations between FEV 1 and FVC ( r G = 1.00), and moderately negative genetic correlations between FTSST and FEV 1 ( r G = −0.33) and FVC ( r G = −0.42). FEV 1 and FVC, as well as FEV 1 and handgrip, displayed high common environmental correlations ( r C = 1.00), and there were moderate correlations between FVC and handgrip ( r C = 0.44). FEV 1 and FVC showed high unique environmental correlations ( r E = 0.76) and low correlations between handgrip and FEV 1 ( r E = 0.17), FVC ( r E = 0.14), and FTSST ( r E = −0.13) with positive or negative direction. We conclude that genetic factors contribute significantly to the individual differences in common indicators of daily functioning (FEV 1 , handgrip, and FTSST). FEV 1 and FVC were genetically and environmentally correlated. Pulmonary function and FTSST may share similar sets of genes but in the negative direction. Pulmonary function and muscle strength may have a shared environmental background.
    Materialart: Online-Ressource
    ISSN: 1832-4274 , 1839-2628
    URL: Article
    DOI: 10.1017/thg.2016.97
    Sprache: Englisch
    Verlag: Cambridge University Press (CUP)
    Publikationsdatum: 2017
    ZDB Id: 2184274-7
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 5
    Online-Ressource
    Online-Ressource
    Genetic and Environmental Basis in Phenotype Correlation Between Physical Function and Cognition in Aging Chinese Twins
    Cambridge University Press (CUP) ; 2017
    In:  Twin Research and Human Genetics Vol. 20, No. 1 ( 2017-02), p. 60-65
    Details
    In: Twin Research and Human Genetics, Cambridge University Press (CUP), Vol. 20, No. 1 ( 2017-02), p. 60-65
    Kurzfassung: Although the correlation between cognition and physical function has been well studied in the general population, the genetic and environmental nature of the correlation has been rarely investigated. We conducted a classical twin analysis on cognitive and physical function, including forced expiratory volume in one second (FEV 1 ), forced vital capacity (FVC), handgrip strength, five-times-sit-to-stand test (FTSST), near visual acuity, and number of teeth lost in 379 complete twin pairs. Bivariate twin models were fitted to estimate the genetic and environmental correlation between physical and cognitive function. Bivariate analysis showed mildly positively genetic correlations between cognition and FEV 1 , r G = 0.23 [95% CI: 0.03, 0.62], as well as FVC, r G = 0.35 [95% CI: 0.06, 1.00]. We found that FTSST and cognition presented very high common environmental correlation, r C = -1.00 [95% CI: -1.00, -0.57], and low but significant unique environmental correlation, r E = -0.11 [95% CI: -0.22, -0.01], all in the negative direction. Meanwhile, near visual acuity and cognition also showed unique environmental correlation, r E = 0.16 [95% CI: 0.03, 0.27]. We found no significantly genetic correlation for cognition with handgrip strength, FTSST, near visual acuity, and number of teeth lost. Cognitive function was genetically related to pulmonary function. The FTSST and cognition shared almost the same common environmental factors but only part of the unique environmental factors, both with negative correlation. In contrast, near visual acuity and cognition may positively share part of the unique environmental factors.
    Materialart: Online-Ressource
    ISSN: 1832-4274 , 1839-2628
    URL: Article
    DOI: 10.1017/thg.2016.98
    Sprache: Englisch
    Verlag: Cambridge University Press (CUP)
    Publikationsdatum: 2017
    ZDB Id: 2184274-7
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 6
    Online-Ressource
    Online-Ressource
    The Danish Twin Registry: Linking Surveys, National Registers, and Biological Information
    Cambridge University Press (CUP) ; 2013
    In:  Twin Research and Human Genetics Vol. 16, No. 1 ( 2013-02), p. 104-111
    Details
    In: Twin Research and Human Genetics, Cambridge University Press (CUP), Vol. 16, No. 1 ( 2013-02), p. 104-111
    Kurzfassung: Over the last 60 years, the resources and the research in the Danish Twin Registry (DTR) have periodically been summarized. Here, we give a short overview of the DTR and a more comprehensive description of new developments in the twenty-first century. First, we outline our experience over the last decade of combining questionnaire and survey data with national demographic, social, and health registers in Statistics Denmark. Second, we describe our most recent data collection effort, which was conducted during the period 2008–2011 and included both in-person assessments of 14,000+ twins born 1931–1969 and sampling of biological material, hereby expanding and consolidating the DTR biobank. Third, two examples of intensively studied twin cohorts are given. The new developments in the DTR in the last decade have facilitated the ongoing research and laid the groundwork for new research directions.
    Materialart: Online-Ressource
    ISSN: 1832-4274 , 1839-2628
    URL: Article
    DOI: 10.1017/thg.2012.77
    Sprache: Englisch
    Verlag: Cambridge University Press (CUP)
    Publikationsdatum: 2013
    ZDB Id: 2184274-7
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 7
    Online-Ressource
    Online-Ressource
    Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project
    Cambridge University Press (CUP) ; 2015
    In:  Twin Research and Human Genetics Vol. 18, No. 5 ( 2015-10), p. 557-570
    Details
    In: Twin Research and Human Genetics, Cambridge University Press (CUP), Vol. 18, No. 5 ( 2015-10), p. 557-570
    Kurzfassung: A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m 2 in childhood and adolescence and up to 0.2 kg/m 2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.
    Materialart: Online-Ressource
    ISSN: 1832-4274 , 1839-2628
    URL: Article
    DOI: 10.1017/thg.2015.57
    Sprache: Englisch
    Verlag: Cambridge University Press (CUP)
    Publikationsdatum: 2015
    ZDB Id: 2184274-7
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 8
    Online-Ressource
    Online-Ressource
    Multivariate Modeling of Body Mass Index, Pulse Pressure, Systolic and Diastolic Blood Pressure in Chinese Twins
    Cambridge University Press (CUP) ; 2015
    In:  Twin Research and Human Genetics Vol. 18, No. 1 ( 2015-02), p. 73-78
    Details
    In: Twin Research and Human Genetics, Cambridge University Press (CUP), Vol. 18, No. 1 ( 2015-02), p. 73-78
    Kurzfassung: Systolic and diastolic blood pressure, pulse pressure (PP), and body mass index (BMI) are heritable traits in human metabolic health but their common genetic and environmental backgrounds are not well investigated. The aim of this article was to explore the phenotypic and genetic associations among PP, systolic blood pressure (SBP), diastolic blood pressure (DBP), and BMI. The studied sample contained 615 twin pairs (17–84 years) collected in the Qingdao municipality. Univariate and multivariate structural equation models were fitted for assessing the genetic and environmental contributions. The AE model combining additive genetic (A) and unique environmental (E) factors produced the best fit for each four phenotypes. Heritability estimated in univariate analysis ranged from 0.42 to 0.74 with the highest for BMI (95% CI 0.70–0.78), and the lowest for PP (95% CI 0.34–0.49). The multivariate model estimated (1) high genetic correlations for DBP with SBP (0.87), PP with SBP (0.75); (2) low–moderate genetic correlations between PP and DBP (0.32), each BP component and BMI (0.24–0.37); (3) moderate unique environmental correlation for PP with SBP (0.68) and SBP with DBP (0.63); (4) there was no significant unique environmental correlation between PP and BMI. Overall, our multivariate analyses revealed common genetic and environmental backgrounds for PP, BP, and BMI in Chinese twins.
    Materialart: Online-Ressource
    ISSN: 1832-4274 , 1839-2628
    URL: Article
    DOI: 10.1017/thg.2014.83
    Sprache: Englisch
    Verlag: Cambridge University Press (CUP)
    Publikationsdatum: 2015
    ZDB Id: 2184274-7
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 9
    Online-Ressource
    Online-Ressource
    The Genetic Basis for Cognitive Ability, Memory, and Depression Symptomatology in Middle-Aged and Elderly Chinese Twins
    Cambridge University Press (CUP) ; 2015
    In:  Twin Research and Human Genetics Vol. 18, No. 1 ( 2015-02), p. 79-85
    Details
    In: Twin Research and Human Genetics, Cambridge University Press (CUP), Vol. 18, No. 1 ( 2015-02), p. 79-85
    Kurzfassung: The genetic influences on aging-related phenotypes, including cognition and depression, have been well confirmed in the Western populations. We performed the first twin-based analysis on cognitive performance, memory and depression status in middle-aged and elderly Chinese twins, representing the world's largest and most rapidly aging population. The sample consisted of 384 twin pairs with a median age of 50 years. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) scale; memory was assessed using the revised Wechsler Adult Intelligence scale; depression symptomatology was evaluated by the self-reported 30-item Geriatric Depression (GDS-30)scale. Both univariate and multivariate twin models were fitted to the three phenotypes with full and nested models and compared to select the best fitting models. Univariate analysis showed moderate-to-high genetic influences with heritability 0.44 for cognition and 0.56 for memory. Multivariate analysis by the reduced Cholesky model estimated significant genetic (r G = 0.69) and unique environmental (r E = 0.25) correlation between cognitive ability and memory. The model also estimated weak but significant inverse genetic correlation for depression with cognition (-0.31) and memory (-0.28). No significant unique environmental correlation was found for depression with other two phenotypes. In conclusion, there can be a common genetic architecture for cognitive ability and memory that weakly correlates with depression symptomatology, but in the opposite direction.
    Materialart: Online-Ressource
    ISSN: 1832-4274 , 1839-2628
    URL: Article
    DOI: 10.1017/thg.2014.76
    Sprache: Englisch
    Verlag: Cambridge University Press (CUP)
    Publikationsdatum: 2015
    ZDB Id: 2184274-7
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 10
    Online-Ressource
    Online-Ressource
    Heritability and whole genome linkage of pulse pressure in Chinese twin pairs — Corrigendum
    Cambridge University Press (CUP) ; 2012
    In:  Twin Research and Human Genetics Vol. 15, No. 6 ( 2012-12), p. 796-796
    Details
    In: Twin Research and Human Genetics, Cambridge University Press (CUP), Vol. 15, No. 6 ( 2012-12), p. 796-796
    Materialart: Online-Ressource
    ISSN: 1832-4274 , 1839-2628
    URL: Article
    DOI: 10.1017/thg.2012.84
    Sprache: Englisch
    Verlag: Cambridge University Press (CUP)
    Publikationsdatum: 2012
    ZDB Id: 2184274-7
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...