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  • 1
    Online Resource
    Online Resource
    Plasma vitamin D is associated with fasting insulin and homeostatic model assessment of insulin resistance in young adult males, but not females, of the Jerusalem Perinatal Study
    Cambridge University Press (CUP) ; 2015
    In:  Public Health Nutrition Vol. 18, No. 7 ( 2015-05), p. 1324-1331
    Details
    In: Public Health Nutrition, Cambridge University Press (CUP), Vol. 18, No. 7 ( 2015-05), p. 1324-1331
    Abstract: To examine cross-sectional relationships between plasma vitamin D and cardiometabolic risk factors in young adults. Design Data were collected from interviews, physical examinations and biomarker measurements. Total plasma 25-hydroxyvitamin D (25(OH)D) was measured using LC–tandem MS. Associations between 25(OH)D and cardiometabolic risk factors were modelled using weighted linear regression with robust estimates of standard errors. Setting Individuals born in Jerusalem during 1974–1976. Subjects Participants of the Jerusalem Perinatal Study ( n 1204) interviewed and examined at age 32 years. Participants were oversampled for low and high birth weight and for maternal pre-pregnancy obesity. Results Mean total 25(OH)D concentration among participants was 21·7 ( sd 8·9) ng/ml. Among males, 25(OH)D was associated with homeostatic model assessment of insulin resistance (natural log-transformed, β =−0·011, P =0·004) after adjustment for BMI. However, these associations were not present among females ( P for sex interaction=0·005). Conclusions We found evidence for inverse associations of 25(OH)D with markers of insulin resistance among males, but not females, in a healthy, young adult Caucasian population. Prospective studies and studies conducted on other populations investigating sex-specific effects of vitamin D on cardiometabolic risk factors are warranted.
    Type of Medium: Online Resource
    ISSN: 1368-9800 , 1475-2727
    URL: Article
    DOI: 10.1017/S1368980014001475
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2015
    detail.hit.zdb_id: 2016337-X
    SSG: 21
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  • 2
    Online Resource
    Online Resource
    Plasma phospholipid and dietary α-linolenic acid, mortality, CHD and stroke: the Cardiovascular Health Study
    Cambridge University Press (CUP) ; 2014
    In:  British Journal of Nutrition Vol. 112, No. 7 ( 2014-10-14), p. 1206-1213
    Details
    In: British Journal of Nutrition, Cambridge University Press (CUP), Vol. 112, No. 7 ( 2014-10-14), p. 1206-1213
    Abstract: Previous studies have suggested that long-chain n -3 fatty acids derived from seafood are associated with a lower risk of mortality, CHD and stroke. Whether α-linolenic acid (ALA, 18 : 3 n -3), a plant-derived long-chain essential n -3 fatty acid, is associated with a lower risk of these outcomes is unclear. The aim of the present study was to examine the associations of plasma phospholipid and dietary ALA with the risk of mortality, CHD and stroke among older adults who participated in the Cardiovascular Health Study, a cohort study of adults aged ≥ 65 years. A total of 2709 participants were included in the plasma phospholipid ALA analysis and 2583 participants were included in the dietary ALA analysis. Cox regression was used to assess the associations of plasma phospholipid and dietary ALA with the risk of mortality, incident CHD and stroke. In minimally and multivariable-adjusted models, plasma phospholipid ALA was found to be not associated with the risk of mortality, incident CHD or stroke. After adjustment for age, sex, race, enrolment site, education, smoking status, diabetes, BMI, alcohol consumption, treated hypertension and total energy intake, higher dietary ALA intake was found to be associated with a lower risk of total and non-cardiovascular mortality; on comparing the highest quintiles of dietary ALA with the lowest quintiles, the HR for total mortality and non-cardiovascular mortality were found to be 0·73 (95 % CI 0·61, 0·88) and 0·64 (95 % CI 0·52, 0·80), respectively. Dietary ALA was found to be not associated with the risk of cardiovascular mortality, incident CHD or stroke. In conclusion, the results of the present suggest study that dietary ALA, but not plasma phospholipid ALA, is associated with a lower risk of total and non-cardiovascular mortality in older adults.
    Type of Medium: Online Resource
    ISSN: 0007-1145 , 1475-2662
    URL: Article
    DOI: 10.1017/S0007114514001925
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2014
    detail.hit.zdb_id: 2016047-1
    SSG: 12
    SSG: 21
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