GLORIA

GEOMAR Library Ocean Research Information Access

X

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
Filter
  • Cambridge University Press (CUP)  (3)
  • 1
    Online-Ressource
    Online-Ressource
    Trajectories of cognitive decline in different types of dementia
    Cambridge University Press (CUP) ; 2015
    In:  Psychological Medicine Vol. 45, No. 5 ( 2015-04), p. 1051-1059
    Details
    In: Psychological Medicine, Cambridge University Press (CUP), Vol. 45, No. 5 ( 2015-04), p. 1051-1059
    Kurzfassung: To investigate trajectories of cognitive decline in patients with different types of dementia compared to controls in a longitudinal study. Method. In 199 patients with Alzheimer's disease (AD), 10 with vascular dementia (VaD), 26 with dementia with Lewy bodies (DLB), 20 with behavioural variant frontotemporal dementia (bvFTD), 15 with language variant frontotemporal dementia (lvFTD) and 112 controls we assessed five cognitive domains: memory, language, attention, executive and visuospatial functioning, and global cognition (Mini-Mental State Examination, MMSE). All subjects had at least two neuropsychological assessments (median 2, range 2–7). Neuropsychological data were standardized into z scores using baseline performance of controls as reference. Linear mixed models (LMMs) were used to estimate baseline cognitive functioning and cognitive decline over time for each group, adjusted for age, gender and education. Results. At baseline, patients with dementia performed worse than controls in all cognitive domains ( p 〈 0.05) except visuospatial functioning, which was only impaired in patients with AD and DLB ( p 〈 0.001). During follow-up, patients with AD declined in all cognitive domains ( p 〈 0.001). DLB showed decline in every cognitive domain except language and global cognition. bvFTD showed rapid decline in memory, language, attention and executive functioning (all p 〈 0.01) whereas visuospatial functioning remained fairly stable. lvFTD declined mostly in attention and executive functioning ( p 〈 0.01). VaD showed decline in attention and executive functioning. Conclusions. We show cognitive trajectories of different types of dementia. These estimations of natural disease course have important value for the design of clinical trials as neuropsychological measures are increasingly being used as outcome measures.
    Materialart: Online-Ressource
    ISSN: 0033-2917 , 1469-8978
    URL: Article
    DOI: 10.1017/S0033291714002153
    RVK:
    XA 10000
    Sprache: Englisch
    Verlag: Cambridge University Press (CUP)
    Publikationsdatum: 2015
    ZDB Id: 1470300-2
    SSG: 5,2
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 2
    Online-Ressource
    Online-Ressource
    Most rapid cognitive decline in APOE ε4 negative Alzheimer's disease with early onset
    Cambridge University Press (CUP) ; 2009
    In:  Psychological Medicine Vol. 39, No. 11 ( 2009-11), p. 1907-1911
    Details
    In: Psychological Medicine, Cambridge University Press (CUP), Vol. 39, No. 11 ( 2009-11), p. 1907-1911
    Kurzfassung: We aimed to compare the rate of cognitive decline in patients with early and late onset Alzheimer's disease (AD) and to investigate the potentially modifying influence of the apolipoprotein E (APOE) genotype. Method We included 99 patients with early onset AD (age ⩽65 years) and 192 patients with late onset AD (age 〉 65 years) who had at least two scores on the Mini-Mental State Examination (MMSE) (range 2–14) obtained at least 1 year apart. Linear mixed models were performed to investigate the rate of cognitive decline dependent on age at onset (AAO) and APOE genotype. Results The mean ( s.d .) age for patients with early onset AD was 57.7 (4.5) years, and 74.5 (5.1) years for patients with late onset AD. AAO was not associated with baseline MMSE [β ( s.e .)=0.8 (0.5), p =0.14]. However, patients with early onset showed a faster decline on the MMSE [β ( s.e .)=2.4 (0.1) points/year] than those with late onset [β ( s.e .)=1.7 (0.1) points/year, p =0.00]. After stratification according to APOE genotype, APOE ε4 non-carriers with early onset showed faster cognitive decline than non-carriers with late onset [2.4 (0.3) v . 1.3 (0.3) points/year, p =0.01]. In APOE ε4 carriers, no difference in rate of cognitive decline was found between patients with early and late onset [β ( s.e .)=0.2 (0.2), p =0.47]. Conclusion Patients with early onset AD show more rapid cognitive decline than patients with late onset, suggesting that early onset AD follows a more aggressive course. Furthermore, this effect seems to be most prominent in patients with early onset who do not carry the genetic APOE ε4 risk factor for AD.
    Materialart: Online-Ressource
    ISSN: 0033-2917 , 1469-8978
    URL: Article
    DOI: 10.1017/S0033291709005492
    RVK:
    XA 10000
    Sprache: Englisch
    Verlag: Cambridge University Press (CUP)
    Publikationsdatum: 2009
    ZDB Id: 1470300-2
    SSG: 5,2
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 3
    Online-Ressource
    Online-Ressource
    Time to diagnosis in young-onset dementia as compared with late-onset dementia
    Cambridge University Press (CUP) ; 2013
    In:  Psychological Medicine Vol. 43, No. 2 ( 2013-02), p. 423-432
    Details
    In: Psychological Medicine, Cambridge University Press (CUP), Vol. 43, No. 2 ( 2013-02), p. 423-432
    Kurzfassung: The extent to which specific factors influence diagnostic delays in dementia is unclear. Therefore, the aim of the present study was to compare duration from symptom onset to diagnosis for young-onset dementia (YOD) and late-onset dementia (LOD) and to assess the effect of age at onset, type of dementia, gender, living situation, education and family history of dementia on this duration. Method Data on 235 YOD and 167 LOD patients collected from caregivers from two prospective cohort studies were used. Multiple linear regression analysis was performed. Results The duration between symptom onset and the diagnosis of YOD exceeded that of LOD by an average of 1.6 years (2.8 v . 4.4 years). Young age and being diagnosed with frontotemporal dementia were related to increases in the time to diagnosis. Subjects with vascular dementia experienced shorter time to diagnosis. Conclusions There is a need to raise special awareness of YOD to facilitate a timely diagnosis.
    Materialart: Online-Ressource
    ISSN: 0033-2917 , 1469-8978
    URL: Article
    DOI: 10.1017/S0033291712001122
    RVK:
    XA 10000
    Sprache: Englisch
    Verlag: Cambridge University Press (CUP)
    Publikationsdatum: 2013
    ZDB Id: 1470300-2
    SSG: 5,2
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...