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  • Cambridge University Press (CUP)  (6)
  • 1
    Online Resource
    Online Resource
    Variants Near CCK Receptors are Associated With Electrophysiological Responses to Pre-pulse Startle Stimuli in a Mexican American Cohort
    Cambridge University Press (CUP) ; 2015
    In:  Twin Research and Human Genetics Vol. 18, No. 6 ( 2015-12), p. 727-737
    Details
    In: Twin Research and Human Genetics, Cambridge University Press (CUP), Vol. 18, No. 6 ( 2015-12), p. 727-737
    Abstract: Neurophysiological measurements of the response to pre-pulse and startle stimuli have been suggested to represent an important endophenotype for both substance dependence and other select psychiatric disorders. We have previously shown, in young adult Mexican Americans (MA), that presentation of a short delay acoustic pre-pulse, prior to the startle stimuli can elicit a late negative component at about 400 msec (N4S), in the event-related potential (ERP), recorded from frontal cortical areas. In the present study, we investigated whether genetic factors associated with this endophenotype could be identified. The study included 420 (age 18–30 years) MA men ( n = 170), and women ( n = 250). DNA was genotyped using an Affymetrix Axiom Exome1A chip. An association analysis revealed that the CCKAR and CCKBR (cholecystokinin A and B receptor) genes each had a nearby variant that showed suggestive significance with the amplitude of the N4S component to pre-pulse stimuli. The neurotransmitter cholecystokinin ( CCK ), along with its receptors, CCKAR and CCKBR , have been previously associated with psychiatric disorders, suggesting that variants near these genes may play a role in the pre-pulse/startle response in this cohort.
    Type of Medium: Online Resource
    ISSN: 1832-4274 , 1839-2628
    URL: Article
    DOI: 10.1017/thg.2015.77
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2015
    detail.hit.zdb_id: 2184274-7
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study
    Cambridge University Press (CUP) ; 2019
    In:  Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques Vol. 46, No. 5 ( 2019-09), p. 499-511
    Details
    In: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Cambridge University Press (CUP), Vol. 46, No. 5 ( 2019-09), p. 499-511
    Abstract: Évaluation complète d’une étude de cohorte canadienne portant sur la démence et la neuro-dégénérescence. Contexte : L’évaluation globale de la neuro-dégénérescence et de la démence (COMPASS-ND), étude de cohorte du Consortium canadien en neuro-dégénérescence associée au vieillissement (CCNV), représente une initiative nationale visant à promouvoir la recherche portant sur la démence et à soutenir les programmes de recherche des équipes du CCNV. Totalisant 2310 sujets recrutés partout au pays, cette cohorte longitudinale regroupe des individus fortement « phénotypés » qui présentent diverses formes de démence et de pertes de mémoire légères. En plus de sujets âgés dont les fonctions cognitives sont intactes, ces 2310 sujets ont permis de valider les hypothèses formulées par les équipes du CCNV. Méthodes : Nous avons utilisé de nombreux documents pour décrire cette étude : le protocole de la COMPASS-ND ; la demande initiale de subvention ; le cinquième rapport d’étape semi-annuel du CCNV soumis aux Instituts de recherche en santé du Canada (IRSC) en décembre 2017 ; ainsi que d’autres documents produits à la suite de modifications consécutives à la mise en œuvre de ce projet. Résultats : L’étude de cohorte COMPASS-ND du CCNV inclut des participants de partout au Canada dont les divers états cognitifs sont associés à des maladies neurodégénératives ou au risque d’en souffrir. Ils feront l’objet d’un large éventail d’examens expérimentaux, cliniques, génétiques et d’imagerie afin d’aborder de manière spécifique les causes, le diagnostic, le traitement et la prévention de ces états cognitifs chez les personnes âgées. Les données obtenues à la suite d’évaluations cliniques et cognitives, ainsi que celles issues d’échantillons biologiques, d’imagerie cérébrale, de tests génétiques et de dons de cerveaux, seront utilisées pour tester les hypothèses générées par les équipes de recherche du CCNV et d’autres chercheurs canadiens. Cette étude constitue donc à ce jour l’étude canadienne la plus complète et la plus ambitieuse au sujet de la démence. La présentation des données initiales ayant eu lieu en 2018, la cohorte devrait atteindre sa taille maximale d’ici à 2020. Conclusion : La disponibilité des données de l’étude COMPASS-ND stimulera considérablement la recherche sur la démence au Canada au cours des prochaines années.
    Type of Medium: Online Resource
    ISSN: 0317-1671 , 2057-0155
    URL: Article
    DOI: 10.1017/cjn.2019.27
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2019
    detail.hit.zdb_id: 2577275-2
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  • 3
    Online Resource
    Online Resource
    The Rapid ASKAP Continuum Survey I: Design and first results
    Cambridge University Press (CUP) ; 2020
    In:  Publications of the Astronomical Society of Australia Vol. 37 ( 2020)
    Details
    In: Publications of the Astronomical Society of Australia, Cambridge University Press (CUP), Vol. 37 ( 2020)
    Abstract: The Rapid ASKAP Continuum Survey (RACS) is the first large-area survey to be conducted with the full 36-antenna Australian Square Kilometre Array Pathfinder (ASKAP) telescope. RACS will provide a shallow model of the ASKAP sky that will aid the calibration of future deep ASKAP surveys. RACS will cover the whole sky visible from the ASKAP site in Western Australia and will cover the full ASKAP band of 700–1800 MHz. The RACS images are generally deeper than the existing NRAO VLA Sky Survey and Sydney University Molonglo Sky Survey radio surveys and have better spatial resolution. All RACS survey products will be public, including radio images (with $\sim$ 15 arcsec resolution) and catalogues of about three million source components with spectral index and polarisation information. In this paper, we present a description of the RACS survey and the first data release of 903 images covering the sky south of declination $+41^\circ$ made over a 288-MHz band centred at 887.5 MHz.
    Type of Medium: Online Resource
    ISSN: 1323-3580 , 1448-6083
    URL: Article
    DOI: 10.1017/pasa.2020.41
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2560489-2
    detail.hit.zdb_id: 2079225-6
    SSG: 16,12
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  • 4
    Online Resource
    Online Resource
    New Observations of LBV Environments
    Cambridge University Press (CUP) ; 1991
    In:  Symposium - International Astronomical Union Vol. 143 ( 1991), p. 505-512
    Details
    In: Symposium - International Astronomical Union, Cambridge University Press (CUP), Vol. 143 ( 1991), p. 505-512
    Abstract: Two observational programs which provide new information about particular LBVs through investigations of their immediate surroundings are described. (1) Digital spectral classification of OB supergiants in compact groups apparently associated with Radcliffe 127 and S Doradus has revealed several interesting objects and indicates which of them are likely to be generically related to the LBVs. (2) Velocity-resolved images of the Eta Carinae shell show qualitatively new features, which will contribute substantially to the interpretation of its complex spatial/kinematical structure.
    Type of Medium: Online Resource
    ISSN: 0074-1809
    URL: Article
    DOI: 10.1017/S0074180900045678
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1991
    SSG: 16,12
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  • 5
    Online Resource
    Online Resource
    The utility of a drought index for assessing the drought hazard in Devon and Cornwall, South West England
    Cambridge University Press (CUP) ; 1998
    In:  Meteorological Applications Vol. 5, No. 4 ( 1998-12), p. 359-372
    Details
    In: Meteorological Applications, Cambridge University Press (CUP), Vol. 5, No. 4 ( 1998-12), p. 359-372
    Type of Medium: Online Resource
    ISSN: 1350-4827 , 1469-8080
    URL: Article
    DOI: 10.1017/S1350482798000899
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1998
    detail.hit.zdb_id: 1482937-X
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  • 6
    Online Resource
    Online Resource
    Absorption of dietary alkylresorcinols in ileal-cannulated pigs and rats
    Cambridge University Press (CUP) ; 2003
    In:  British Journal of Nutrition Vol. 90, No. 4 ( 2003-10), p. 787-794
    Details
    In: British Journal of Nutrition, Cambridge University Press (CUP), Vol. 90, No. 4 ( 2003-10), p. 787-794
    Abstract: Alkylresorcinols (AR) are amphiphilic 1,3-dihydroxy-5-alkyl phenolic lipids. AR in food are only found in the outer layers of wheat and rye grains, and in whole grains are present at concentrations of 500–1000 μg/g. In wheat and rye, there are five main homologues, differing in the length of the odd-numbered alkyl chain (from seventeen to twenty-five C atoms long). Because AR may be bioactive, and might serve as biomarkers for these cereals, their absorption was investigated in model experiments with pigs and rats. Pigs with a cannula in the terminal ileum were fed four diets containing rye fractions with different levels of AR and the ileal effluents were analysed. The ileal recovery of AR was found to vary between 21 and 40 %, with no major difference between different chain-length homologues. The absorption of AR by rats was investigated by feeding 14 C-labelled heneicosylresorcinol (C 21:0 ). Of the total activity, about 34% was recovered in the urine, showing that the labelled AR was absorbed and metabolised by rats. AR were mostly cleared from rats by 60h. It is concluded that AR are absorbed in the small intestine of single-stomached animals and excreted in metabolised form in the urine, and might contribute to the nutritional qualities of wholegrain wheat and rye diets.
    Type of Medium: Online Resource
    ISSN: 0007-1145 , 1475-2662
    URL: Article
    DOI: 10.1079/BJN2003965
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2003
    detail.hit.zdb_id: 2016047-1
    SSG: 12
    SSG: 21
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