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  • Cambridge University Press (CUP)  (9)
  • 1
    Online Resource
    Online Resource
    Neuromuscular Junction Disorders. 2004. By Matthew N. Meriggioli, James F. HowardJr. , C. Michel Harper. Published by Marcel Dekker. 300 pages. C$231 approx.
    Cambridge University Press (CUP) ; 2005
    In:  Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques Vol. 32, No. 2 ( 2005-05), p. 268-268
    Details
    In: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Cambridge University Press (CUP), Vol. 32, No. 2 ( 2005-05), p. 268-268
    Type of Medium: Online Resource
    ISSN: 0317-1671 , 2057-0155
    URL: Article
    DOI: 10.1017/S0317167100115914
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2005
    detail.hit.zdb_id: 197622-9
    detail.hit.zdb_id: 2577275-2
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  • 2
    Online Resource
    Online Resource
    Indications for Interferon Beta 1B Treatment in Multiple Sclerosis
    Cambridge University Press (CUP) ; 1995
    In:  Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques Vol. 22, No. 4 ( 1995-11), p. 334-334
    Details
    In: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Cambridge University Press (CUP), Vol. 22, No. 4 ( 1995-11), p. 334-334
    Type of Medium: Online Resource
    ISSN: 0317-1671 , 2057-0155
    URL: Article
    DOI: 10.1017/S0317167100039615
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1995
    detail.hit.zdb_id: 197622-9
    detail.hit.zdb_id: 2577275-2
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  • 3
    Online Resource
    Online Resource
    MRI Contributes to the Differentiation Between MS and HTLV-I Associated Myelopathy in British Columbian Coastal Natives
    Cambridge University Press (CUP) ; 2003
    In:  Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques Vol. 30, No. 1 ( 2003-02), p. 41-48
    Details
    In: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Cambridge University Press (CUP), Vol. 30, No. 1 ( 2003-02), p. 41-48
    Abstract: La myélopathie associée au HTLV-1/paraparésie spastique tropicale (HAM/TSP) chez les autochtones de la région côtière de la Colombie Britannique était jusqu’à ce jour un diagnostic basé sur la clinique et le laboratoire. Cependant, les anomalies observées à l’imagerie par résonance magnétique (IRM) ont été bien décrites dans d’autres populations chez qui le HAM/TSP est endémique. Méthodes: Nous avons comparé les scans de patients atteints de HAM/TSP avec ceux de patients autochtones de la région côtière de la Colombie Britannique HTLV-1 positifs sans HAM/TSP et de patients atteints de sclérose en plaques (SEP) présentant une paraparésie progressive afin d’évaluer l’utilité de l’IRM comme outil diagnostique dans cette population. Résultats: L’atrophie de la moelle thoracique et l’augmentation du signal dans la substance blanche périventriculaire et sous-corticale sur les images pondérées en T2, qui sont des observations non spécifiques typiques, ont été confirmées chez les patients atteints de HAM/TSP. Malgré le manque de spécificité des observations à l’IRM entre les patients atteints de HAM/TSP et les porteurs de HTLV-1, des critères qui pourraient permettre de différentier les patients atteints de HAM/TSP des patients atteints de SEP présentant un tableau clinique similaire ont été établis. Conclusions: Des corrélations cliniques et radiologiques suggèrent que l’investigation longitudinale par IRM documentant l’évolution de la HAM/TSP peut révéler la signification clinique de ces lésions et aider à définir le rôle de l’IRM dans le diagnostic de cette maladie. L’IRM ajoute de l’information supplémentaire importante aux données immunologiques et cliniques pour distinguer la SEP de la HAM/TSP.
    Type of Medium: Online Resource
    ISSN: 0317-1671 , 2057-0155
    URL: Article
    DOI: 10.1017/S0317167100002420
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2003
    detail.hit.zdb_id: 197622-9
    detail.hit.zdb_id: 2577275-2
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  • 4
    Online Resource
    Online Resource
    Consensus Statement of the Canadian MS Clinics Network on: The Use of Disease Modifying Agents in Multiple Sclerosis
    Cambridge University Press (CUP) ; 1999
    In:  Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques Vol. 26, No. 4 ( 1999-11), p. 274-275
    Details
    In: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Cambridge University Press (CUP), Vol. 26, No. 4 ( 1999-11), p. 274-275
    Type of Medium: Online Resource
    ISSN: 0317-1671 , 2057-0155
    URL: Article
    DOI: 10.1017/S0317167100000378
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1999
    detail.hit.zdb_id: 197622-9
    detail.hit.zdb_id: 2577275-2
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  • 5
    Online Resource
    Online Resource
    Acetylcholine Receptor Antibodies in Myasthenia Gravis: Use of a Qualitative Assay for Diagnostic Purposes
    Cambridge University Press (CUP) ; 1987
    In:  Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques Vol. 14, No. 3 ( 1987-08), p. 297-302
    Details
    In: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Cambridge University Press (CUP), Vol. 14, No. 3 ( 1987-08), p. 297-302
    Abstract: We have modified the techniques of Lindstrom and of Tindall to measure serum acetylcholine receptor antibody using human antigen bound to 125 I-alpha Bungarotoxin. By using 10 ä1 of serum and precipitating antigen-antibody complexes with an excess of staph A, we found that only one out of 43 patients with clinically diagnosed active generalized Myasthenia Gravis had no antibodies. In pooling these results with the results of tests done for diagnostic purposes we found positive results in 54/55 generalized active MG, 8/21 MG in remission, 16/37 ocular MG and 0/55 healthy controls. Two out of 38 non MG were also positive and their clinical diagnosis of botulism and penicillamine treated rheumatoid arthritis have been confirmed by a one year follow-up. Most of these sera were also tested for reactivity with fetal calf AchR. Six out of 49 samples positive with the human receptor were negative with calf receptor. We conclude that our technique is extremely useful for the diagnosis of Myasthenia Gravis and that fetal calf antigen cannot replace human antigen in the assay.
    Type of Medium: Online Resource
    ISSN: 0317-1671 , 2057-0155
    URL: Article
    DOI: 10.1017/S0317167100026652
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1987
    detail.hit.zdb_id: 197622-9
    detail.hit.zdb_id: 2577275-2
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  • 6
    Online Resource
    Online Resource
    Ventricular Size, Cognitive Function and Depression in Patients with Multiple Sclerosis
    Cambridge University Press (CUP) ; 1992
    In:  Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques Vol. 19, No. 3 ( 1992-08), p. 352-356
    Details
    In: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Cambridge University Press (CUP), Vol. 19, No. 3 ( 1992-08), p. 352-356
    Abstract: The purpose of this study was to explore further the hypothesis that changes in cognitive function may occur in the mild stages of multiple sclerosis (MS) by determining whether ventricular enlargement was related to cognitive function. Ten measures of ventricular size were made in a sample of 123 MS patients with mild disability and 60 well-matched healthy controls. In addition, sixteen tests of cognitive function and the Beck Depression Inventory were administered. For the MS group, there were significant correlations between the ventricular measures and cognitive performance but not for the normal controls. Scores on the Beck Depression Inventory were not correlated with either cognitive performance or ventricular enlargement. These findings suggest that for the MS group cognitive impairment was related to the disease process but not to the level of depression.
    Type of Medium: Online Resource
    ISSN: 0317-1671 , 2057-0155
    URL: Article
    DOI: 10.1017/S0317167100041986
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1992
    detail.hit.zdb_id: 197622-9
    detail.hit.zdb_id: 2577275-2
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  • 7
    Online Resource
    Online Resource
    CCSVI: Hope, Hype or Snake Oil?
    Cambridge University Press (CUP) ; 2010
    In:  Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques Vol. 37, No. 6 ( 2010-11), p. 716-716
    Details
    In: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Cambridge University Press (CUP), Vol. 37, No. 6 ( 2010-11), p. 716-716
    Type of Medium: Online Resource
    ISSN: 0317-1671 , 2057-0155
    URL: Article
    DOI: 10.1017/S0317167100051349
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2010
    detail.hit.zdb_id: 197622-9
    detail.hit.zdb_id: 2577275-2
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  • 8
    Online Resource
    Online Resource
    HTLV-I Associated Myelopathy: An Endemic Disease of Canadian Aboriginals of the Northwest Pacific Coast
    Cambridge University Press (CUP) ; 1993
    In:  Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques Vol. 20, No. 4 ( 1993-11), p. 302-306
    Details
    In: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Cambridge University Press (CUP), Vol. 20, No. 4 ( 1993-11), p. 302-306
    Abstract: Human T-cell lymphotropic virus type 1 (HTLV-I) is responsible for HTLV-I associated myelopathy or tropical spastic paraparesis (HAM/TSP) and for adult T-cell leukemia/lymphoma (ATLL). Both diseases have been well described in individuals living in Japan, West Indies, Seychelles Islands and Columbia where infection with HTLV-I is considered endemic and in persons whose descendants originated from these endemic areas. We report here 4 cases of HAM/TSP in 4 natives from 4 different tribal groups from British Columbia (B.C.). These are the first case reports of HTLV-I linked diseases found among North American Aboriginals. Possible routes of infection for HTLV-I infection included sexual transmission, breast feeding, blood transfusions and IV drug use. The seroprevalence of HTLV-I in North American Native population is unknown and we suggest that it is endemic in this ethnic group.
    Type of Medium: Online Resource
    ISSN: 0317-1671 , 2057-0155
    URL: Article
    DOI: 10.1017/S0317167100048216
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1993
    detail.hit.zdb_id: 197622-9
    detail.hit.zdb_id: 2577275-2
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  • 9
    Online Resource
    Online Resource
    Treatment of Acquired Autoimmune Myasthenia Gravis: a Topic Review
    Cambridge University Press (CUP) ; 1992
    In:  Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques Vol. 19, No. 3 ( 1992-08), p. 360-375
    Details
    In: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Cambridge University Press (CUP), Vol. 19, No. 3 ( 1992-08), p. 360-375
    Abstract: We propose a new approach to staging the disease based on clinical and immunological response to treatment. We oppose clinical remission to immunological remission and define total clinical remission as the goal of therapy. We describe the use, side effects and indications of established therapies. Acetycholine esterase inhibitors are only a symptomatic treatment as is plasma exchange. Usefulness and limits of thymectomy, corticosteroids and immunosuppressants are described here. Their goal is to reduce the auto-immune process. Long-term hazards from these medications are described and methods to reduce their potential risks are suggested. We suggest the number of patients having life threatening complications while undergoing aggressive immunosuppression can be reduced by a systematic approach to follow-up. In the second part of this review article, adapting management to specific situations is emphasized in refractory disease, respiratory failure, neonatal and juvenile forms of the disease. The special situation of seronegative myasthenia is discussed.
    Type of Medium: Online Resource
    ISSN: 0317-1671 , 2057-0155
    URL: Article
    DOI: 10.1017/S0317167100042001
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1992
    detail.hit.zdb_id: 197622-9
    detail.hit.zdb_id: 2577275-2
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