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  • 1
    Online Resource
    Online Resource
    A Genome Scan for Eye Color in 502 Twin Families: Most Variation is due to a QTL on Chromosome 15q
    Cambridge University Press (CUP) ; 2004
    In:  Twin Research Vol. 7, No. 2 ( 2004-04-01), p. 197-210
    Details
    In: Twin Research, Cambridge University Press (CUP), Vol. 7, No. 2 ( 2004-04-01), p. 197-210
    Type of Medium: Online Resource
    ISSN: 1369-0523 , 0000-0000
    URL: Article
    DOI: 10.1375/136905204323016186
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2004
    detail.hit.zdb_id: 2184274-7
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    The Dunn Worry Questionnaire and the Paranoia Worries Questionnaire: new assessments of worry
    Cambridge University Press (CUP) ; 2020
    In:  Psychological Medicine Vol. 50, No. 5 ( 2020-04), p. 771-780
    Details
    In: Psychological Medicine, Cambridge University Press (CUP), Vol. 50, No. 5 ( 2020-04), p. 771-780
    Abstract: The cognitive process of worry, which keeps negative thoughts in mind and elaborates the content, contributes to the occurrence of many mental health disorders. Our principal aim was to develop a straightforward measure of general problematic worry suitable for research and clinical treatment. Our secondary aim was to develop a measure of problematic worry specifically concerning paranoid fears. Methods An item pool concerning worry in the past month was evaluated in 250 non-clinical individuals and 50 patients with psychosis in a worry treatment trial. Exploratory factor analysis and item response theory (IRT) informed the selection of scale items. IRT analyses were repeated with the scales administered to 273 non-clinical individuals, 79 patients with psychosis and 93 patients with social anxiety disorder. Other clinical measures were administered to assess concurrent validity. Test-retest reliability was assessed with 75 participants. Sensitivity to change was assessed with 43 patients with psychosis. Results A 10-item general worry scale (Dunn Worry Questionnaire; DWQ) and a five-item paranoia worry scale (Paranoia Worries Questionnaire; PWQ) were developed. All items were highly discriminative (DWQ a = 1.98–5.03; PWQ a = 4.10–10.7), indicating small increases in latent worry lead to a high probability of item endorsement. The DWQ was highly informative across a wide range of the worry distribution, whilst the PWQ had greatest precision at clinical levels of paranoia worry. The scales demonstrated excellent internal reliability, test-retest reliability, concurrent validity and sensitivity to change. Conclusions The new measures of general problematic worry and worry about paranoid fears have excellent psychometric properties.
    Type of Medium: Online Resource
    ISSN: 0033-2917 , 1469-8978
    URL: Article
    DOI: 10.1017/S0033291719000588
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2020
    detail.hit.zdb_id: 1470300-2
    SSG: 5,2
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  • 3
    Online Resource
    Online Resource
    Reliability of the House and Brackmann grading system for facial palsy
    Cambridge University Press (CUP) ; 1989
    In:  The Journal of Laryngology & Otology Vol. 103, No. 11 ( 1989-11), p. 1045-1046
    Details
    In: The Journal of Laryngology & Otology, Cambridge University Press (CUP), Vol. 103, No. 11 ( 1989-11), p. 1045-1046
    Abstract: The House and Brackmann grading system has been recommended as a universal standard for assessing the degree of facial palsy. This study examined the inter-observer reliability of this system. Three observers assigned a grade to each patient, examined independently, on the same day. Forty patients with a unilateral facial palsy of varying aetiology and severity were assessed. Of the 120 judgements, eight were in dispute, by a maximum of one grade, giving an inter-observer reliability of 93 per cent. We conclude that the House and Brackmann grading system is a simple and robust method of assessing facial function.
    Type of Medium: Online Resource
    ISSN: 0022-2151 , 1748-5460
    URL: Article
    DOI: 10.1017/S002221510011093X
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1989
    detail.hit.zdb_id: 2013209-8
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  • 4
    Online Resource
    Online Resource
    Joint developmental trajectories of internalizing and externalizing disorders between childhood and adolescence
    Cambridge University Press (CUP) ; 2017
    In:  Development and Psychopathology Vol. 29, No. 3 ( 2017-08), p. 919-928
    Details
    In: Development and Psychopathology, Cambridge University Press (CUP), Vol. 29, No. 3 ( 2017-08), p. 919-928
    Abstract: This study sought to identify trajectories of DSM-IV based internalizing (INT) and externalizing (EXT) problem scores across childhood and adolescence and to provide insight into the comorbidity by modeling the co-occurrence of INT and EXT trajectories. INT and EXT were measured repeatedly between age 7 and age 15 years in over 7,000 children and analyzed using growth mixture models. Five trajectories were identified for both INT and EXT, including very low, low, decreasing, and increasing trajectories. In addition, an adolescent onset trajectory was identified for INT and a stable high trajectory was identified for EXT. Multinomial regression showed that similar EXT and INT trajectories were associated. However, the adolescent onset INT trajectory was independent of high EXT trajectories, and persisting EXT was mainly associated with decreasing INT. Sex and early life environmental risk factors predicted EXT and, to a lesser extent, INT trajectories. The association between trajectories indicates the need to consider comorbidity when a child presents with INT or EXT disorders, particularly when symptoms start early. This is less necessary when INT symptoms start at adolescence. Future studies should investigate the etiology of co-occurring INT and EXT and the specific treatment needs of these severely affected children.
    Type of Medium: Online Resource
    ISSN: 0954-5794 , 1469-2198
    URL: Article
    DOI: 10.1017/S0954579416000572
    RVK:
    CL 1000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2017
    detail.hit.zdb_id: 1501055-7
    SSG: 5,2
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  • 5
    Online Resource
    Online Resource
    Do the Genetic or Environmental Determinants of Anxiety and Depression Change with Age? A Longitudinal Study of Australian Twins
    Cambridge University Press (CUP) ; 2004
    In:  Twin Research Vol. 7, No. 1 ( 2004-2-1), p. 39-53
    Details
    In: Twin Research, Cambridge University Press (CUP), Vol. 7, No. 1 ( 2004-2-1), p. 39-53
    Type of Medium: Online Resource
    ISSN: 0000-0000 , 1369-0523
    URL: Article
    DOI: 10.1375/13690520460741435
    Language: Unknown
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2004
    detail.hit.zdb_id: 2184274-7
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Birth weight and cardiometabolic risk factors: a discordant twin study in the UK Biobank
    Cambridge University Press (CUP) ; 2023
    In:  Journal of Developmental Origins of Health and Disease Vol. 14, No. 2 ( 2023-04), p. 242-248
    Details
    In: Journal of Developmental Origins of Health and Disease, Cambridge University Press (CUP), Vol. 14, No. 2 ( 2023-04), p. 242-248
    Abstract: One of the longstanding debates in life-course epidemiology is whether an adverse intrauterine environment, often proxied by birth weight, causally increases the future risk of cardiometabolic disease. The use of a discordant twin study design, which controls for the influence of shared genetic and environmental confounding factors, may be useful to investigate whether this relationship is causal. We conducted a discordant twin study of 120 monozygotic (MZ) and 148 dizygotic (DZ) twin pairs from the UK Biobank to explore the potential causal relationships between birth weight and a broad spectrum of later-life cardiometabolic risk factors. We used a linear mixed model to investigate the association between birth weight and later-life cardiometabolic risk factors for twins, allowing for both within-pair differences and between-pair differences in birth weight. Of primary interest is the within-pair association between differences in birth weight and cardiometabolic risk factors, which could reflect an intrauterine effect on later-life risk factors. We found no strong evidence of association in MZ twins between the within-pair differences in birth weight and most cardiometabolic risk factors in later life, except for nominal associations with C-reactive protein and insulin-like growth factor 1. However, these associations were not replicated in DZ twin pairs. Our study provided no strong evidence for intrauterine effects on later-life cardiometabolic risk factors, which is consistent with previous large-scale studies of singletons testing the potential causal relationship. It does not support the hypothesis that adverse intrauterine environments increase the risk of cardiometabolic disease in later life.
    Type of Medium: Online Resource
    ISSN: 2040-1744 , 2040-1752
    URL: Article
    DOI: 10.1017/S2040174422000538
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2554780-X
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  • 7
    Online Resource
    Online Resource
    ℵ 0 -categorical structures with arbitrarily fast growth of algebraic closure
    Cambridge University Press (CUP) ; 2002
    In:  Journal of Symbolic Logic Vol. 67, No. 3 ( 2002-09), p. 897-909
    Details
    In: Journal of Symbolic Logic, Cambridge University Press (CUP), Vol. 67, No. 3 ( 2002-09), p. 897-909
    Abstract: Various results have been proved about growth rates of certain sequences of integers associated with infinite permutation groups. Most of these concern the number of orbits of the automorphism group of an ℵ 0 -categorical structure on the set of unordered n -subsets or on the set of n -tuples of elements of . (Recall that by the Ryll-Nardzewski Theorem, if is countable and ℵ 0 -categorical, the number of the orbits of its automorphism group Aut( ) on the set of n -tuples from is finite and equals the number of complete n -types consistent with the theory of .) The book [Ca90] is a convenient reference for these results. One of the oldest (in the realms of ‘folklore’) is that for any sequence ( K n ) n ∈ℕ of natural numbers there is a countable ℵ 0 -categorical structure such that the number of orbits of Aut( ) on the set of n -tuples from is greater than k n for all n . These investigations suggested the study of the growth rate of another sequence. Let be an ℵ 0 -categorical structure and X be a finite subset of . Let acl( X ) be the algebraic closure of X , that is, the union of the finite X -definable subsets of . Equivalently, this is the union of the finite orbits on of Aut( )( X ), the pointwise stabiliser of X in Aut( ). Define
    Type of Medium: Online Resource
    ISSN: 0022-4812 , 1943-5886
    URL: Article
    DOI: 10.2178/jsl/1190150137
    RVK:
    CA 1000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2002
    detail.hit.zdb_id: 2010607-5
    SSG: 5,1
    SSG: 17,1
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  • 8
    Online Resource
    Online Resource
    A cautionary note on using Mendelian randomization to examine the Barker hypothesis and Developmental Origins of Health and Disease (DOHaD)
    Cambridge University Press (CUP) ; 2021
    In:  Journal of Developmental Origins of Health and Disease Vol. 12, No. 5 ( 2021-10), p. 688-693
    Details
    In: Journal of Developmental Origins of Health and Disease, Cambridge University Press (CUP), Vol. 12, No. 5 ( 2021-10), p. 688-693
    Abstract: Recent studies have used Mendelian randomization (MR) to investigate the observational association between low birth weight (BW) and increased risk of cardiometabolic outcomes, specifically cardiovascular disease, glycemic traits, and type 2 diabetes (T2D), and inform on the validity of the Barker hypothesis. We used simulations to assess the validity of these previous MR studies, and to determine whether a better formulated model can be used in this context. Genetic and phenotypic data were simulated under a model of no direct causal effect of offspring BW on cardiometabolic outcomes and no effect of maternal genotype on offspring cardiometabolic risk through intrauterine mechanisms; where the observational relationship between BW and cardiometabolic risk was driven entirely by horizontal genetic pleiotropy in the offspring (i.e. offspring genetic variants affecting both BW and cardiometabolic disease simultaneously rather than a mechanism consistent with the Barker hypothesis). We investigated the performance of four commonly used MR analysis methods (weighted allele score MR (WAS-MR), inverse variance weighted MR (IVW-MR), weighted median MR (WM-MR), and MR-Egger) and a new approach, which tests the association between maternal genotypes related to offspring BW and offspring cardiometabolic risk after conditioning on offspring genotype at the same loci. We caution against using traditional MR analyses, which do not take into account the relationship between maternal and offspring genotypes, to assess the validity of the Barker hypothesis, as results are biased in favor of a causal relationship. In contrast, we recommend the aforementioned conditional analysis framework utilizing maternal and offspring genotypes as a valid test of not only the Barker hypothesis, but also to investigate hypotheses relating to the Developmental Origins of Health and Disease more broadly.
    Type of Medium: Online Resource
    ISSN: 2040-1744 , 2040-1752
    URL: Article
    DOI: 10.1017/S2040174420001105
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2554780-X
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  • 9
    Online Resource
    Online Resource
    Expansions of fields by angular functions
    Cambridge University Press (CUP) ; 2008
    In:  Journal of the Institute of Mathematics of Jussieu Vol. 7, No. 4 ( 2008-10), p. 735-750
    Details
    In: Journal of the Institute of Mathematics of Jussieu, Cambridge University Press (CUP), Vol. 7, No. 4 ( 2008-10), p. 735-750
    Abstract: The notion of an angular function has been introduced by Zilber as one possible way of connecting non-commutative geometry with two ‘counterexamples’ from model theory: the non-classical Zariski curves of Hrushovski and Zilber, and Poizat's field with green points. This article discusses some questions of Zilber relating to existentially closed structures in the class of algebraically closed fields with an angular function.
    Type of Medium: Online Resource
    ISSN: 1474-7480 , 1475-3030
    URL: Article
    DOI: 10.1017/S1474748008000200
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2008
    detail.hit.zdb_id: 2092996-1
    SSG: 17,1
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  • 10
    Online Resource
    Online Resource
    Ample Dividing
    Cambridge University Press (CUP) ; 2003
    In:  Journal of Symbolic Logic Vol. 68, No. 4 ( 2003-12), p. 1385-1402
    Details
    In: Journal of Symbolic Logic, Cambridge University Press (CUP), Vol. 68, No. 4 ( 2003-12), p. 1385-1402
    Abstract: We construct a stable one-based, trivial theory with a reduct which is not trivial. This answers a question of John B. Goode. Using this, we construct a stable theory which is n -ample for all natural numbers n , and does not interpret an infinite group.
    Type of Medium: Online Resource
    ISSN: 0022-4812 , 1943-5886
    URL: Article
    DOI: 10.2178/jsl/1067620194
    RVK:
    CA 1000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2003
    detail.hit.zdb_id: 2010607-5
    SSG: 5,1
    SSG: 17,1
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