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  • 1
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 1997
    In:  International Psychogeriatrics Vol. 8, No. S3 ( 1997-05), p. 443-445
    In: International Psychogeriatrics, Cambridge University Press (CUP), Vol. 8, No. S3 ( 1997-05), p. 443-445
    Abstract: The recognition that behavioral disturbances of dementia are an entity that deserves study raises the question of exactly how these behaviors should be investigated. To obtain useful and relevant data, researchers must carefully design their studies, considering the potential difficulties of studying elderly, cognitively impaired patients. Of particular concern is whether patients with Alzheimer's disease or vascular dementia should be included in the same study or whether basic differences between these two diseases warrant separate investigations.
    Type of Medium: Online Resource
    ISSN: 1041-6102 , 1741-203X
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1997
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  • 2
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 2003
    In:  International Psychogeriatrics Vol. 15, No. 2 ( 2003-06), p. 121-133
    In: International Psychogeriatrics, Cambridge University Press (CUP), Vol. 15, No. 2 ( 2003-06), p. 121-133
    Abstract: Background: Early diagnosis of Alzheimer's disease (AD) is critical for adequate treatment and care. Recently it has been shown that functional magnetic resonance imaging (fMRI) can be important in preclinical detection of AD. The purpose of this study was to examine possible differences in memory-related brain activation between persons with high versus low risk for AD. This was achieved by combining a validated neurocognitive screening battery (the 7-minutes test) with memory assessment and fMRI. Methods: One hundred two healthy community-living persons with subjective memory complaints were recruited through advertisement and tested with the 7-minutes test. Based on their test performance they were classified as having either high ( n = 8) or low risk ( n = 94) for AD. Six high-risk individuals and six age-, sex-, and education-matched low-risk individuals were investigated with fMRI while engaged in episodic memory tasks. Results: The high-risk individuals performed worse than low-risk individuals on tests of episodic memory. Patterns of brain activity during episodic encoding and retrieval showed significant gourp differences ( p 〈 .05 corrected). During both encoding and retrieval, the low-risk persons showed increased activity relative to a baseline condition in prefrontal brain regions that previously have been implicated in episodic memory. By contrast, the high-risk persons did not significantly activate any prefrontal regions, but instead showed increased activity in visual occipito-temporal regions. Conclusion: Patterns of prefrontal brain activity related to episodic memory differ between persons with high versus low risk for AD, and lowered prefrontal activity may predict subsequent disease.
    Type of Medium: Online Resource
    ISSN: 1041-6102 , 1741-203X
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2003
    detail.hit.zdb_id: 2147136-8
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  • 3
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 1993
    In:  International Psychogeriatrics Vol. 5, No. 2 ( 1993-09), p. 157-168
    In: International Psychogeriatrics, Cambridge University Press (CUP), Vol. 5, No. 2 ( 1993-09), p. 157-168
    Abstract: The purpose of this study was to establish whether physical health and cognitive function in married long-term patients or in their spouses determines why some patients are cared for in home care while others reside in nursing homes. Out of 38 married couples with a sick spouse cared for in a nursing home, 23 couples were studied; out of 34 couples with a sick spouse cared for in home care, 22 patients and 25 spouses were studied. The results showed no significant differences in physical health score either between the two groups of patients, or between the two groups of spouses. Both home-care patients and nursing home patients had low cognitive function scores, but nursing home patients had significantly lower scores. A multivariate analysis showed that physical health and cognitive function explained only 20% of patients' residence. Between the two groups of spouses there was no difference in cognitive function score. The conclusion is that physical health status and cognitive function explain only to a small extent why married long-term care patients are cared for in nursing homes or in home care.
    Type of Medium: Online Resource
    ISSN: 1041-6102 , 1741-203X
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1993
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  • 4
    In: International Psychogeriatrics, Cambridge University Press (CUP), Vol. 8, No. 2 ( 1996-06), p. 335-342
    Abstract: Barry Reisberg : Alistair Burns, a researcher and a clinician, is very active in the International Psychogeriatric Association (IPA). He comes to us from the U.K., and will add a unique perspective. Sture Eriksson is from Umea, Sweden, and he is a geriatrician. He sees patients and he also has a research perspective and, more particularly for this meeting, he is the chairman ofthe IPA's research committee. Sandy Finkel is the current president of IPA. He's aclinician, he sees patients, and he does research both in nursing home settings and in outpatient, settings. Serge Gauthier is a neurologist. He comes to us from Montreal, Canada, and he is indeed a clinician and also a researcher and he is the director of the Canadian clinical trials consortium. Raymond Levy is the president-elect of the IPA. He is a professor at the Maudsley in London; he remains a clinician and he also has a truly longitudinal view of the field. Laurie Mallery is from Halifax. Nova Scoria. She's a geriatrician. She's very rnuch involved with patients, and she also has become involved in research and is familiar with research issues, and obviously lends a unique perspective.
    Type of Medium: Online Resource
    ISSN: 1041-6102 , 1741-203X
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1996
    detail.hit.zdb_id: 2147136-8
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  • 5
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 1996
    In:  International Psychogeriatrics Vol. 8, No. 4 ( 1996-12), p. 659-668
    In: International Psychogeriatrics, Cambridge University Press (CUP), Vol. 8, No. 4 ( 1996-12), p. 659-668
    Abstract: In the present open study, the long-term safety, tolerability, and efficacy of citalopram in the treatment of elderly people with emotional disturbances were studied. One hundred twenty-three elderly patients with symptoms of depression-anxiety were included. Most of the patients (76%) were demented. Fifty-two patients completed a 12-month treatment. Irritability, depressed mood, anxiety, restlessness, and fear-panic were significantly reduced. The severity of illness from baseline to Month 9 was rated as significantly improved. The side effects were infrequent and mostly mild.
    Type of Medium: Online Resource
    ISSN: 1041-6102 , 1741-203X
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1996
    detail.hit.zdb_id: 2147136-8
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  • 6
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 2000
    In:  International Psychogeriatrics Vol. 12, No. S1 ( 2000-07), p. 89-91
    In: International Psychogeriatrics, Cambridge University Press (CUP), Vol. 12, No. S1 ( 2000-07), p. 89-91
    Abstract: The underlying causes of behavioral and psychological symptoms of dementia (BPSD) can be related to biologic factors, such as changes in brain morphology and neurotransmitter functions, and to personal factors, such as previous personality, psychological defenses, and coping strategies. We must also consider the extent to which environmental factors contribute to the etiology of BPSD.
    Type of Medium: Online Resource
    ISSN: 1041-6102 , 1741-203X
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2000
    detail.hit.zdb_id: 2147136-8
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  • 7
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 2000
    In:  International Psychogeriatrics Vol. 12, No. 4 ( 2000-12), p. 537-545
    In: International Psychogeriatrics, Cambridge University Press (CUP), Vol. 12, No. 4 ( 2000-12), p. 537-545
    Abstract: It is well known that abnormalities in the brain serotonin system exist in patients with dementia. The present study was performed in order to investigate whether a peripheral serotonin system marker, the platelet 5-HT 2A receptor, is affected in dementia. Thirty-eight patients with Alzheimer's disease (AD), 13 patients with vascular dementia, and 40 healthy controls were included in the study. There were no significant differences in receptor density for 5-HT 2A receptor binding between the groups. Affinity of the radioligand to the receptor was significantly lower in AD than in vascular dementia and in the controls ( p = .006 and p = .003, respectively), whereas there was no significant difference between the vascular dementia group and the control group. In 12 patients, treatment with citalopram was started due to depression or agitation. This treatment significantly reduced the Behavioral Pathology in Alzheimer's Disease Rating Scale scores ( p = .001), but did not affect the platelet 5-HT 2A receptor status. There was no correlation between 5-HT 2A receptor status before treatment and the therapeutic effect of citalopram. The study indicates that platelet 5-HT 2A receptor status is of limited value as a peripheral marker in dementia.
    Type of Medium: Online Resource
    ISSN: 1041-6102 , 1741-203X
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2000
    detail.hit.zdb_id: 2147136-8
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