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  • Cambridge University Press (CUP)  (7)
  • 1
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 1993
    In:  Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques Vol. 20, No. S3 ( 1993-05), p. S53-S61
    In: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, Cambridge University Press (CUP), Vol. 20, No. S3 ( 1993-05), p. S53-S61
    Abstract: The activity of single cells in the cerebellar and motor cortex of awake monkeys was recorded during separate studies of whole-arm reaching movements and during the application of force-pulse perturbations to handheld objects. Two general observations about the contribution of the cerebellum to the control of movement emerge from the data. The first, derived from the study of whole arm reaching, suggests that although both the motor cortex and cerebellum generate a signal related to movement direction, the cerebellar signal is less precise and varies from trial to trial even when the movement kinematics remain unchanged. The second observation, derived from the study of predictable perturbations of a hand-held object, indicates that cerebellar cortical neurons better reflect preparatory motor strategies formed from the anticipation of cutaneous and proprioceptive stimuli acquired by previous experience. In spite of strong relations to grip force and receptive fields stimulated by preparatory grip forces increase, the neurons of the percentral motor cortex showed very little anticipatory activity compared with either the premotor areas or the cerebellum.
    Type of Medium: Online Resource
    ISSN: 0317-1671 , 2057-0155
    RVK:
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1993
    detail.hit.zdb_id: 2577275-2
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  • 2
    In: European Psychiatry, Cambridge University Press (CUP), Vol. 7, No. 4 ( 1992), p. 153-159
    Abstract: The prognostic significance of an index episode of affective disorder with delusions was assessed in a longitudinal study of a cohort of adolescent psychiatric inpatients ( n = 43). Part I of a study has been reported in a previous article. Initial assessmentdata (anamnestic variables, clinical assessment) did not discriminate between onset of affective disorder and schizophrenia. Part II of the study provides a longitudinal perspective of the cohort's diagnostic and life adjustment: diagnoses of schizophrenia increased, schizophreniform disorders disappeared, affective disorders were stable and a schizo-affective category emerged. Patients in the schizophrenic category had severely impaired life adjustment, while the level of functioning in unipolar and bipolar patients was consistently satisfactory. Compared to the initial diagnosis, the cohort showed a tendency to develop into schizophrenia. It is too early to affirm that every adolescent with delusional symptoms at onset will later develop schizophrenia, however, this risk appears real.
    Type of Medium: Online Resource
    ISSN: 0924-9338 , 1778-3585
    RVK:
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1992
    detail.hit.zdb_id: 2005377-0
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  • 3
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 1990
    In:  Psychiatry and Psychobiology Vol. 5, No. 1 ( 1990), p. 13-22
    In: Psychiatry and Psychobiology, Cambridge University Press (CUP), Vol. 5, No. 1 ( 1990), p. 13-22
    Abstract: Does the presence of delirious ideas during a major depressive or manic episode indicate a different affection with its own specific developmental and therapeutic clinical characteristics, expressing itself in particular as a more marked functional handicap over a period or years? If so, what of its relationship with manic depressive illness and schizophrenia? The answer to these questions appears complex; indeed, literature on the subject has always varied between a dichotomic classification and a unitary one. Until around 1980, adolescents suffering from delirious affective disorders were usually considered as schizophrenics because delirious disorders appeared to be more significant than cyclothymic disorders. Since that time, with the introduction of the DSM III (1980), it has been more likely to place these disorders in the category of manic depressive illness. The category of schizoaffective disorders has become residual. Is there a continuity linking schizophrenia and manic depressive illness, or are they distinct entities? Is the category of schizoaffective disorders precursory or residual? To attempt to answer these questions, we designated a sample group of delirious adolescents, some suffering from affective disorders and some not. We followed their development prospectively over a period of 5 years, studying the diagnosis, prognosis and therapy applied to their cases. This article is a description of the personal and family history and the delirious semiology of the group's index episode. We will deal with the development and therapy of these patients elsewhere. Thanks to this study we have observed that nowadays delirious disorders are being detected more successfully in adolescent subjects. The age at which the disorders begin, contrary to what is commonly stated, is more or less the same whatever the diagnostic category: schizophrenia or manic depressive disorder. As far as family history is concerned, we have found that affective disorders predominate irrespective of diagnostic category. As far as Personal history is concerned, we noted a majority of affective disorders among unipolar, bipolar and schizoaffective patients, and a majority of schizophreniform disorders among schizophrenic patients. An analysis of psychotic semiology reveals a high occurrence of non-congruence and thought disorders in bipolar and schizoaffective patients, whereas in the past these signs were thought to be « pathognomonic » with respect to schizophrenia. In all, on the strength of personal and family history and clinical diagnosis, it seems very difficult to distinguish between a delirious affective disorder (especially a manic disorder) and the first stages of schizophrenia in an adolescent subject during an early delirious episode. There are no elements which would permit predictions to be made with certainty. The category of schizoaffective illness is not particularly specific; some diagnostic elements (for example personal history) bring it close to affective disorders, whilst some symptoms (for example thought disorders) make it appear more akin to schizophrenia. Clearly, any differential diagnosis attempting to distinguish between delirious affective disorders and delirious schizophrenic disorders must be defined with regard to the development of the individual patient; we shall discuss this in the second part of our study.
    Type of Medium: Online Resource
    ISSN: 0767-399X , 2633-0903
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1990
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  • 4
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 1988
    In:  Psychiatry and Psychobiology Vol. 3, No. 2 ( 1988), p. 87-98
    In: Psychiatry and Psychobiology, Cambridge University Press (CUP), Vol. 3, No. 2 ( 1988), p. 87-98
    Abstract: Our study involved a statistical comparison of two groups of patients with ano rexia nervosa (according to DSM-III criteria) - below the age of 13, above the age of 13 - who were examine at a child and adolescent psychiatry clinic. It showed the following resuits. 1) Anorexia nervosa is not very frequent among children who are less than 13 years of age, in comparison with) adolescents; indeed the younger group comprises 14 patients over a period of 7.5 years, whereas the older group includes 37 patients over a period of 2.5 years. 2) The proportion of boys is higher in the younger group (below 13) since we find 5 boys and 9 girls, boys repre senting 35% of this group; the predominance of girls over boys is more clear at puberty since we have one boy; for 36 girls, with boys representing only 3% of the older group. 3) Growth delays are marked in young anorexic patients. In our series, only boys were affected by it (3). The age of onset was 10 years for the first one and 11.5 for the other 2. Two patients had reached their final height which was normal. The third patient had a height below - 2 SD at age 23. One can question the absence of growth delay in our younger female series. In our opinion, the reason is that our anorexic girls were older than 10 year. of age at the time of onset of the illness. Their growth was then well-advanced and they were likely to have started their puberty. In contrast, those boys with growth arrest were all prepubertal at the time of onset of the anorexia, disorder. 4) The clinical symptomatology is more spectacular in the younger group: – a premorbid State characterized by eating problems during early childhood; – a rapid weight loss. Weight is often below 25% of the previous one but thinness is pronounced, as there is little fat tissue before puberty. In the young group, the weight loss is generally between 15 and 20%; – in 3 cases out of 14, hydration refusal was associated with food refusal; this particulur symptom was not observed in the older group. These last two observations challenge the appropriateness of DSM-III criteria for anorexia nervosa in young children. 5) In contrast, there was no significant difference between the 2 groups regarding: the frequency of psychiatric disorders among parents and siblings: 17,8% in parents of group I, primarily affective disorders (16%). Eating disorders was the most often diagnosed pathology among our patients’ siblings; the position of the anorexic patient within the sibling System, the social status of parents, the situation of the parental home; physical hyperactivity, occurrence of induced vomiting, use of laxatives and Somatic complaints; prevalence of depression as an associated diagnosis; it is fairly high in both groups since we find 86% with depression in the younger group (12 out of 14) and 60% in the older group (22 cases out of 37); severity of psychosocial stress; the level of adjustment and of academic and social functioning during the past year. Among the various adjustment problems observed in many of our anorexic patients, we find social relationship problems as well as cognitive distortions which lead to poor academie achievement in spite of adequate intellectual potential and overinvolvement in scholl work. 6) Our conclusions concerning the outcome of anorexia are incomplete because of a lack of precision in some of the data collected, the relatively brief duration of follow-up (patients front group I generally benefited front a more regular and prolonged follow-up - an average of 4 years - than patients front groupe 2 - average of 2 years) and because of the sampling weaknesses of the younger group. Weight returned to normal in 78.5% of the cases of group 1 and 54% of the cases of group 2. We noted that it is relatively easy to produce weight gains in anorexic patients. Eating behavior was adequate in 1 subject of group 1 (64%) and 19 subjects of group 2 (51%). Appearance or reappearance of menses are observed in 6 girls out of 9 in group 1 (66.6%) and 20 girls out of 36 in group 2 (55.5%). An evaluation of our subjects mental status (only 12 out of 14 subjects were involved since 2 did not respond to our questions) shows that one female patient presents with chronic anorexia nervosa, involving recurrent episodes of major depression; another female patient had a delusional episode of depression; a third one can be considered as being schizophrenic. Six subjects suffer from chronic anxiety with lack of self-confidence and social phobia for one of them. The last three function adequately in all areas. As we can see, anorexia nervosa is a serious illness with an uncertain prognosis. However, there did not seem to be any difference between the two groups with regard to the evolution of the disease (front a behavioral standpoint). However, we should stress that except for 2 cases, anorexic patients below the age of 13 had been affected by the disorder right before puberty or soon after its beginning.
    Type of Medium: Online Resource
    ISSN: 0767-399X , 2633-0903
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1988
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  • 5
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 2008
    In:  Neuron Glia Biology Vol. 4, No. 2 ( 2008-05), p. 137-152
    In: Neuron Glia Biology, Cambridge University Press (CUP), Vol. 4, No. 2 ( 2008-05), p. 137-152
    Abstract: All vertebrate nervous systems, except those of agnathans, make extensive use of the myelinated fiber, a structure formed by coordinated interplay between neuronal axons and glial cells. Myelinated fibers, by enhancing the speed and efficiency of nerve cell communication allowed gnathostomes to evolve extensively, forming a broad range of diverse lifestyles in most habitable environments. The axon-covering myelin sheaths are structurally and biochemically novel as they contain high portions of lipid and a few prominent low molecular weight proteins often considered unique to myelin. Here we searched genome and EST databases to identify orthologs and paralogs of the following myelin-related proteins: (1) myelin basic protein (MBP), (2) myelin protein zero (MPZ, formerly P0), (3) proteolipid protein (PLP1, formerly PLP), (4) peripheral myelin protein-2 (PMP2, formerly P2), (5) peripheral myelin protein-22 (PMP22) and (6) stathmin-1 (STMN1). Although widely distributed in gnathostome/vertebrate genomes, neither MBP nor MPZ are present in any of nine invertebrate genomes examined. PLP1, which replaced MPZ in tetrapod CNS myelin sheaths, includes a novel ‘tetrapod-specific’ exon (see also Möbius et al., 2009). Like PLP1, PMP2 first appears in tetrapods and like PLP1 its origins can be traced to invertebrate paralogs. PMP22, with origins in agnathans, and STMN1 with origins in protostomes, existed well before the evolution of gnathostomes. The coordinated appearance of MBP and MPZ with myelin sheaths and of PLP1 with tetrapod CNS myelin suggests interdependence – new proteins giving rise to novel vertebrate structures.
    Type of Medium: Online Resource
    ISSN: 1740-925X , 1741-0533
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2008
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 2021
    In:  Disaster Medicine and Public Health Preparedness Vol. 15, No. 4 ( 2021-08), p. 427-430
    In: Disaster Medicine and Public Health Preparedness, Cambridge University Press (CUP), Vol. 15, No. 4 ( 2021-08), p. 427-430
    Abstract: The aim of this study was to determine the involvement of emergency medicine physicians at academic medical centers across the United States as well as their background training, roles in the hospital, and compensation if applicable for time dedicated to preparedness. Methods: A structured survey was delivered by means of email to 109 Chairs of Emergency Medicine across the United States at academic medical centers. Unique email links were provided to track response rate and entered into REDCap database. Descriptive statistics were obtained, including roles in emergency preparedness, training, and compensation. Results: Forty-four of the 109 participants responded, resulting in a response rate of 40.4%. The majority held an administrative role in emergency preparedness. Formal training for the position (participants could select more than 1) included various avenues of education such as emergency medical services fellowship or in-person or online courses. Of the participants, most (93.18%) strongly agreed that it was important to have a physician with expertise in disaster medicine assisting with preparedness. Conclusions: The majority of responding academic medical center participants have taken an active role in hospital emergency preparedness. Education for the roles varied though, often consisted of courses from emergency management agencies. Volunteering their time for compensation was noted by 27.5%.
    Type of Medium: Online Resource
    ISSN: 1935-7893 , 1938-744X
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2375268-3
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  • 7
    Online Resource
    Online Resource
    Cambridge University Press (CUP) ; 1989
    In:  Psychiatry and Psychobiology Vol. 4, No. 1 ( 1989), p. 13-21
    In: Psychiatry and Psychobiology, Cambridge University Press (CUP), Vol. 4, No. 1 ( 1989), p. 13-21
    Abstract: The DSM III classification System of psychiatric diagnoses has not much been used in children and adolescents: psychiatric disorders have often been ignored and the line between normal and pathological is difficult to determine in children and often determined by teachers. DSM III diagnoses in children and adolescents are based on adult's model. Diagnoses are made on two axes. Even DSM III has a separate section for specific diagnoses for children and adolescents, many children fit diagnostic criteria for adult pathology in DSM III and vice versa. This study was made on 894 children and adolescents hospitalized or examined during one day in the department of psychopathology of child and adolescents of Herold’s Hospital in Paris. Diagnoses were established in accordance with the DSM III criteria during meetings of senior physicians of the department; the evaluation was collective. The 894 suspects included 560 subjects less than 13 years’old and 334 subjects over 13; 551 boys and 343 girls. Males are over-represented under 13; but over 13, the numbers of boys and girls are equivalent. A DSM III diagnosis, on axe I ou II, was made in 97% of cases. Under 13, the most frequent diagnoses were mental retardation and disorders with physical signs, specially in boys. In children over 13, affective disorders and eating disorders, specially in girls, were predominant. On axe II, personnality disorders were rarely present; but we observed a lot of specific developmental disorders, specially under 13. On axe III, 20% of this population had physical problems, releable to their psychiatric pathology. On axe IV, there was no difference in the severity of the stressors between the 2 groups of age; but girls had more stressors than boys. On axe V, the over 13 had a power level of functioning than the under 13. The results of this study confirm the others studies as concern the sex ratio. In the other hand, we made much more diagnoses of mental retardation and pervasive developmental disorder than Anderson, for exemple. We had also few cases of conduct disorders and attention deficit disorders than American studies. In addition, in the over 13, we found less schizophrenia than Strober. This discrepancy could be due to the fact that we are extremely cautions about the diagnostic of schizophrenia in an adolescent. The use of the DSM III classification in a child psychiatry department requires a certain degree of precision and coherence, but it lets to carry out clinical research informations with others centers. Its principal defect is the problem of the validity of some categories in children and adolescents dus to the absence of technical references. One may ask if DSM III should be considered as a nosological classification.
    Type of Medium: Online Resource
    ISSN: 0767-399X , 2633-0903
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 1989
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