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  • Cambridge University Press (CUP)  (15)
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  • Cambridge University Press (CUP)  (15)
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  • 1
    Online Resource
    Online Resource
    Design and performance of final optics assembly in SG-II Upgrade laser facility
    Cambridge University Press (CUP) ; 2018
    In:  High Power Laser Science and Engineering Vol. 6 ( 2018)
    Details
    In: High Power Laser Science and Engineering, Cambridge University Press (CUP), Vol. 6 ( 2018)
    Abstract: In high power laser facility for inertial confinement fusion research, final optics assembly (FOA) plays a critical role in the frequency conversion, beam focusing, color separation, beam sampling and debris shielding. The design and performance of FOA in SG-II Upgrade laser facility are mainly introduced here. Due to the limited space and short focal length, a coaxial aspheric wedged focus lens is designed and applied in the FOA configuration. Then the ghost image analysis, the focus characteristic analysis, the B integral control design and the optomechanical design are carried out in the FOA design phase. In order to ensure the FOA performance, two key technologies are developed including measurement and adjustment technique of the wedged focus lens and the stray light management technique based on ground glass. Experimental results show that the design specifications including laser fluence, frequency conversion efficiency and perforation efficiency of the focus spot have been achieved, which meet the requirements of physical experiments well.
    Type of Medium: Online Resource
    ISSN: 2095-4719 , 2052-3289
    URL: Article
    DOI: 10.1017/hpl.2018.8
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2018
    detail.hit.zdb_id: 2723155-0
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  • 2
    Online Resource
    Online Resource
    Association between dietary protein intake and the risk of depressive symptoms in adults
    Cambridge University Press (CUP) ; 2020
    In:  British Journal of Nutrition Vol. 123, No. 11 ( 2020-06-14), p. 1290-1301
    Details
    In: British Journal of Nutrition, Cambridge University Press (CUP), Vol. 123, No. 11 ( 2020-06-14), p. 1290-1301
    Abstract: Depression is an important public health problem. The aim of the study is to explore the associations of total protein intake and protein sources with the risk of depressive symptoms. This cross-sectional study used data from the National Health and Nutrition Examination Survey for the years 2007–2014. Dietary protein intake was obtained from two 24-h dietary recall interviews. Depressive symptoms were assessed by a nine-item Patient Health Questionnaire. Logistic regression models and restricted cubic spline models were used to estimate the associations of total protein intake (g/kg per d) and protein sources with the risk of depressive symptoms. A total of 17 845 individuals aged 18 years and older were included in this study. Total protein intake was inversely associated with the risk of depressive symptoms. The full-adjusted OR of depressive symptoms was 0·34 (95 % CI 0·17, 0·68) for quartile (Q) 4 v . Q1 of total protein intake. For protein intake from milk and milk products, the association with depressive symptoms was significant both for Q2 v . Q1 (OR 0·61; 95 % CI 0·41, 0·93) and Q3 v . Q1 (OR 0·37; 95 % CI 0·24, 0·59) in the full-adjusted model. In the dose–response analysis, the shape of the associations of total protein intake and protein intake from milk and milk products with the risk of depressive symptoms was approximately L-shaped and U-shaped, respectively. The present study demonstrated that total protein intake and protein intake from milk and milk products might reduce the risk of depressive symptoms in US adults.
    Type of Medium: Online Resource
    ISSN: 0007-1145 , 1475-2662
    URL: Article
    DOI: 10.1017/S0007114520000562
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2020
    detail.hit.zdb_id: 2016047-1
    SSG: 12
    SSG: 21
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Invited Letter to Editor in response to: Milk intake and depressive symptom: a risk assessment
    Cambridge University Press (CUP) ; 2021
    In:  British Journal of Nutrition Vol. 126, No. 6 ( 2021-09-28), p. 957-958
    Details
    In: British Journal of Nutrition, Cambridge University Press (CUP), Vol. 126, No. 6 ( 2021-09-28), p. 957-958
    Type of Medium: Online Resource
    ISSN: 0007-1145 , 1475-2662
    URL: Article
    DOI: 10.1017/S0007114520004912
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2021
    detail.hit.zdb_id: 2016047-1
    SSG: 12
    SSG: 21
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Multivariate Modeling of Body Mass Index, Pulse Pressure, Systolic and Diastolic Blood Pressure in Chinese Twins
    Cambridge University Press (CUP) ; 2015
    In:  Twin Research and Human Genetics Vol. 18, No. 1 ( 2015-02), p. 73-78
    Details
    In: Twin Research and Human Genetics, Cambridge University Press (CUP), Vol. 18, No. 1 ( 2015-02), p. 73-78
    Abstract: Systolic and diastolic blood pressure, pulse pressure (PP), and body mass index (BMI) are heritable traits in human metabolic health but their common genetic and environmental backgrounds are not well investigated. The aim of this article was to explore the phenotypic and genetic associations among PP, systolic blood pressure (SBP), diastolic blood pressure (DBP), and BMI. The studied sample contained 615 twin pairs (17–84 years) collected in the Qingdao municipality. Univariate and multivariate structural equation models were fitted for assessing the genetic and environmental contributions. The AE model combining additive genetic (A) and unique environmental (E) factors produced the best fit for each four phenotypes. Heritability estimated in univariate analysis ranged from 0.42 to 0.74 with the highest for BMI (95% CI 0.70–0.78), and the lowest for PP (95% CI 0.34–0.49). The multivariate model estimated (1) high genetic correlations for DBP with SBP (0.87), PP with SBP (0.75); (2) low–moderate genetic correlations between PP and DBP (0.32), each BP component and BMI (0.24–0.37); (3) moderate unique environmental correlation for PP with SBP (0.68) and SBP with DBP (0.63); (4) there was no significant unique environmental correlation between PP and BMI. Overall, our multivariate analyses revealed common genetic and environmental backgrounds for PP, BP, and BMI in Chinese twins.
    Type of Medium: Online Resource
    ISSN: 1832-4274 , 1839-2628
    URL: Article
    DOI: 10.1017/thg.2014.83
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2015
    detail.hit.zdb_id: 2184274-7
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Genetic and Environmental Correlation Analysis of Serum Creatinine Levels in Chinese Twins
    Cambridge University Press (CUP) ; 2023
    In:  Twin Research and Human Genetics Vol. 26, No. 3 ( 2023-06), p. 219-222
    Details
    In: Twin Research and Human Genetics, Cambridge University Press (CUP), Vol. 26, No. 3 ( 2023-06), p. 219-222
    Abstract: Almost all creatinine is excreted by the kidney in individuals. Serum creatinine concentration, a widely used renal function index in clinical practice, can be affected by both genetic and environmental factors, as evidenced by current research exploring the relationship between these factors and kidney function. However, few studies have explored the heritability of serum creatinine in Asian populations. Therefore, we explored the genetic and environmental factors that affect the serum creatinine level in Asian populations. Participants in this study came from the Qingdao Twin Registry in China, and 374 pairs of twins were included, of which 139 pairs were dizygotic twins, whose ages ranged from 40 to 80 years old, and the serum creatinine level ranged from 10 to 126 μmol/L. Structural equation models were constructed using Mx software to calculate heritability, with adjusted covariates being age, sex, and body mass index. The results of heritability analysis showed that ACE was the best fit model. Serum creatinine level is influenced by genetic and environmental factors. The result of heritability was 35.44%, and the influence of shared environmental factors accounted for 52.13%. This study provided the relevant basis for future research on genetic and environmental factors affecting serum creatinine levels in Asian populations.
    Type of Medium: Online Resource
    ISSN: 1832-4274 , 1839-2628
    URL: Article
    DOI: 10.1017/thg.2023.20
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2023
    detail.hit.zdb_id: 2184274-7
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    The Genetic Basis for Cognitive Ability, Memory, and Depression Symptomatology in Middle-Aged and Elderly Chinese Twins
    Cambridge University Press (CUP) ; 2015
    In:  Twin Research and Human Genetics Vol. 18, No. 1 ( 2015-02), p. 79-85
    Details
    In: Twin Research and Human Genetics, Cambridge University Press (CUP), Vol. 18, No. 1 ( 2015-02), p. 79-85
    Abstract: The genetic influences on aging-related phenotypes, including cognition and depression, have been well confirmed in the Western populations. We performed the first twin-based analysis on cognitive performance, memory and depression status in middle-aged and elderly Chinese twins, representing the world's largest and most rapidly aging population. The sample consisted of 384 twin pairs with a median age of 50 years. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) scale; memory was assessed using the revised Wechsler Adult Intelligence scale; depression symptomatology was evaluated by the self-reported 30-item Geriatric Depression (GDS-30)scale. Both univariate and multivariate twin models were fitted to the three phenotypes with full and nested models and compared to select the best fitting models. Univariate analysis showed moderate-to-high genetic influences with heritability 0.44 for cognition and 0.56 for memory. Multivariate analysis by the reduced Cholesky model estimated significant genetic (r G = 0.69) and unique environmental (r E = 0.25) correlation between cognitive ability and memory. The model also estimated weak but significant inverse genetic correlation for depression with cognition (-0.31) and memory (-0.28). No significant unique environmental correlation was found for depression with other two phenotypes. In conclusion, there can be a common genetic architecture for cognitive ability and memory that weakly correlates with depression symptomatology, but in the opposite direction.
    Type of Medium: Online Resource
    ISSN: 1832-4274 , 1839-2628
    URL: Article
    DOI: 10.1017/thg.2014.76
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2015
    detail.hit.zdb_id: 2184274-7
    SSG: 12
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  • 7
    Online Resource
    Online Resource
    Heritability and whole genome linkage of pulse pressure in Chinese twin pairs — Corrigendum
    Cambridge University Press (CUP) ; 2012
    In:  Twin Research and Human Genetics Vol. 15, No. 6 ( 2012-12), p. 796-796
    Details
    In: Twin Research and Human Genetics, Cambridge University Press (CUP), Vol. 15, No. 6 ( 2012-12), p. 796-796
    Type of Medium: Online Resource
    ISSN: 1832-4274 , 1839-2628
    URL: Article
    DOI: 10.1017/thg.2012.84
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2012
    detail.hit.zdb_id: 2184274-7
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    SG-II-Up prototype final optics assembly: optical damage and clean-gas control
    Cambridge University Press (CUP) ; 2015
    In:  High Power Laser Science and Engineering Vol. 3 ( 2015)
    Details
    In: High Power Laser Science and Engineering, Cambridge University Press (CUP), Vol. 3 ( 2015)
    Abstract: The Shenguang-II Upgrade (SG-II Up) facility is an under-construction high-power laser driver with eight beams, 24 kJ energy, 3 ns pulse duration and ultraviolet laser output, in the Shanghai Institute of Optics and Fine Mechanics, China. The prototype design and experimental research of the prototype final optics assembly (FOA), which is one of the most important parts of the SG-II Up facility, have been completed on the ninth beam of the SG-II facility. Thirty-three shots were fired using 1- ${\it\omega}$ energy from 1000 to 4500 J and 3- ${\it\omega}$ energy from 500 to 2403 J with a 3 ns square pulse. During the experiments, emphasis was given to the process of optical damage and to the effects of clean-gas control. A numerical model of the FOA generated by the Integrated Computer Engineering and Manufacturing code for Computational Fluid Dynamics (ICEMCFD) demonstrated that a flux within $1{-}5~\text{l s}^{-1}$ and a 180 s period is effectual to avoid contaminant sputtering to the optics. The presence of surface ‘mooning’ damage and surface spots located outside the clear aperture are induced by contaminants such as wire, silica gel and millimeter order fiber and metal.
    Type of Medium: Online Resource
    ISSN: 2095-4719 , 2052-3289
    URL: Article
    DOI: 10.1017/hpl.2015.1
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2015
    detail.hit.zdb_id: 2723155-0
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  • 9
    Online Resource
    Online Resource
    Target alignment in the Shen-Guang II Upgrade laser facility
    Cambridge University Press (CUP) ; 2018
    In:  High Power Laser Science and Engineering Vol. 6 ( 2018)
    Details
    In: High Power Laser Science and Engineering, Cambridge University Press (CUP), Vol. 6 ( 2018)
    Abstract: The Shen-Guang II Upgrade (SG-II-U) laser facility consists of eight high-power nanosecond laser beams and one short-pulse picosecond petawatt laser. It is designed for the study of inertial confinement fusion (ICF), especially for conducting fast ignition (FI) research in China and other basic science experiments. To perform FI successfully with hohlraum targets containing a golden cone, the long-pulse beam and cylindrical hohlraum as well as the short-pulse beam and cone target alignment must satisfy tight specifications (30 and $20~\unicode[STIX]{x03BC}\text{m}$ rms for each case). To explore new ICF ignition targets with six laser entrance holes (LEHs), a rotation sensor was adapted to meet the requirements of a three-dimensional target and correct beam alignment. In this paper, the strategy for aligning the nanosecond beam based on target alignment sensor (TAS) is introduced and improved to meet requirements of the picosecond lasers and the new six LEHs hohlraum targets in the SG-II-U facility. The expected performance of the alignment system is presented, and the alignment error is also discussed.
    Type of Medium: Online Resource
    ISSN: 2095-4719 , 2052-3289
    URL: Article
    DOI: 10.1017/hpl.2018.4
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2018
    detail.hit.zdb_id: 2723155-0
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  • 10
    Online Resource
    Online Resource
    Who will benefit from computerized cognitive remediation therapy? Evidence from a multisite randomized controlled study in schizophrenia
    Cambridge University Press (CUP) ; 2020
    In:  Psychological Medicine Vol. 50, No. 10 ( 2020-07), p. 1633-1643
    Details
    In: Psychological Medicine, Cambridge University Press (CUP), Vol. 50, No. 10 ( 2020-07), p. 1633-1643
    Abstract: Computerized cognitive remediation therapy (CCRT) is generally effective for the cognitive deficits of schizophrenia. However, there is much uncertainty about what factors mediate or moderate effectiveness and are therefore important to personalize treatment and boost its effects. Method In total, 311 Chinese inpatients with Diagnostic and Statistical Manual of Mental Disorders-IV schizophrenia were randomized to receive CCRT or Active control for 12 weeks with four to five sessions per week. All participants were assessed at baseline, post-treatment and 3-month follow-up. The outcomes were cognition, clinical symptoms and functional outcomes. Results There was a significant benefit in the MATRICS Consensus Cognitive Battery (MCCB) total score for CCRT ( F 1,258 = 5.62; p = 0.02; effect size was 0.27, 95% confidence interval 0.04–0.49). There were no specific moderators of CCRT improvements. However, across both groups, Wisconsin Card Sort Test improvement mediated a positive effect on functional capacity and Digit Span benefit mediated decreases in positive symptoms. In exploratory analyses younger and older participants showed cognitive improvements but on different tests (younger on Symbol Coding Test, while older on the Spatial Span Test). Only the older age group showed MSCEIT benefits at post-treatment. In addition, cognition at baseline negatively correlated with cognitive improvement and those whose MCCB baseline total score was around 31 seem to derive the most benefit. Conclusions CCRT can improve the cognitive function of patients with schizophrenia. Changes in cognitive outcomes also contributed to improvements in functional outcomes either directly or solely in the context of CCRT. Age and the basic cognitive level of the participants seem to affect the cognitive benefits from CCRT.
    Type of Medium: Online Resource
    ISSN: 0033-2917 , 1469-8978
    URL: Article
    DOI: 10.1017/S0033291719001594
    RVK:
    XA 10000
    Language: English
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2020
    detail.hit.zdb_id: 1470300-2
    SSG: 5,2
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