In:
Psychological Medicine, Cambridge University Press (CUP), Vol. 52, No. 6 ( 2022-04), p. 1069-1079
Kurzfassung:
Schizotypy is a putative risk phenotype for psychosis liability, but the overlap of its genetic architecture with schizophrenia is poorly understood. Methods We tested the hypothesis that dimensions of schizotypy (assessed with the SPQ-B) are associated with a polygenic risk score (PRS) for schizophrenia in a sample of 623 psychiatrically healthy, non-clinical subjects from the FOR2107 multi-centre study and a second sample of 1133 blood donors. Results We did not find correlations of schizophrenia PRS with either overall SPQ or specific dimension scores, nor with adjusted schizotypy scores derived from the SPQ (addressing inter-scale variance). Also, PRS for affective disorders (bipolar disorder and major depression) were not significantly associated with schizotypy. Conclusions This important negative finding demonstrates that despite the hypothesised continuum of schizotypy and schizophrenia, schizotypy might share less genetic risk with schizophrenia than previously assumed (and possibly less compared to psychotic-like experiences).
Materialart:
Online-Ressource
ISSN:
0033-2917
,
1469-8978
DOI:
10.1017/S0033291720002822
Sprache:
Englisch
Verlag:
Cambridge University Press (CUP)
Publikationsdatum:
2022
ZDB Id:
1470300-2
SSG:
5,2
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