In:
Pediatric Allergy and Immunology, Wiley, Vol. 27, No. 3 ( 2016-05), p. 283-289
Abstract:
Exposure to low levels of vitamin D in fetal life might affect the developing immune system, and subsequently the risk of childhood eczema. We examined whether 25‐hydroxyvitamin D levels in mid‐gestation and at birth were associated with the risk of eczema until the age of 4 years. Methods In a population‐based prospective cohort study of 3019 mothers and their children, maternal blood samples in mid‐gestation and umbilical cord blood samples at birth were used to determine 25‐hydroxyvitamin D levels (severely deficient 〈 25.0 nmol/l, deficient 25.0–49.9 nmol/l, sufficient 50.0–74.9 nmol/l, optimal ≥75.0 nmol/l). Eczema was prospectively assessed by annual questionnaires until the age of 4 years. Eczema patterns included never, early (age ≤1 year only), late (age 〉 1 year only), and persistent eczema (age ≤ and 〉 1 year). Data were assessed using the generalized estimating equations and multinomial regression models. Results Compared with the optimal 25‐hydroxyvitamin D group, sufficient, deficient, and severely deficient groups of 25‐hydroxyvitamin D level in mid‐gestation were not associated with the risk of overall eczema (odds ratios [95% confidence interval]: 1.09 [0.82, 1.43] , 1.04 [0.87, 1.25], and 0.94 [0.81, 1.10] , p‐values for trend 〉 0.05), nor with eczema per year or eczema patterns in children up to the age of 4 years. Similarly, we observed no associations of 25‐hydroxyvitamin D groups at birth with any eczema outcome. Conclusion Our results suggest that levels of 25‐hydroxyvitamin D in mid‐gestation and at birth are not associated with the risk of overall eczema, eczema per year, or eczema patterns among children until the age of 4 years.
Type of Medium:
Online Resource
ISSN:
0905-6157
,
1399-3038
DOI:
10.1111/pai.2016.27.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2008584-9
detail.hit.zdb_id:
1057059-7
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