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  • Cambridge University Press  (5)
  • Nature Publishing Group (NPG)  (3)
  • Wiley  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    Bulletin of the British Society for the History of Science 1 (1951), S. 144-158 
    ISSN: 0950-5636
    Source: Cambridge Journals Digital Archives
    Topics: History , Natural Sciences in General
    Notes: That remarkable soldier, statesman and man of science, Benjamin Thompson, Count Rumford, has many claims on the interest of the historian of science. He is remembered for certain experiments and conclusions of fundamental importance regarding the nature of heat; he founded the Royal Institution; he was the author of a series of Essays on various aspects of pure and applied science which were celebrated in their day; and he was a pioneer in that field of activity which he described himself as “the application of science to the common purposes of life”. His methods of conservation of heat and economy of fuel, his designs of stoves, fireplaces and cooking utensils were widely used during his lifetime. He was consulted on the laying out of kitchens in hospitals and institutions and his advice was sought by his friends on household problems such as the curing of smoky chimneys and the efficient warming of rooms. He taught his contemporaries to recognise the fire built on an open hearth, the only means of domestic heating and cooking with which they were acquainted, for the ineffective and wasteful contrivance it really was. He held the most enlightened views, which were far in advance of his time, on the waste of fuel and the evils of atmospheric pollution in cities.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    The @British journal for the history of science 1 (1963), S. 396-396 
    ISSN: 0007-0874
    Source: Cambridge Journals Digital Archives
    Topics: History , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    The @British journal for the history of science 1 (1962), S. 49-63 
    ISSN: 0007-0874
    Source: Cambridge Journals Digital Archives
    Topics: History , Natural Sciences in General
    Notes: SynopsisThe paper is an attempt to set the social and historical background against which the Royal Institution was founded, and to trace the events in its very early history. The founder of the Institution was Benjamin Thompson, Count Rumford, that soldier of fortune who took service with the Elector Palatine of Bavaria, and it was in the course of his duties in Munich that his interest in the practical problems of philanthropy was aroused.In London, in the concluding years of the eighteenth century, he was drawn into the group of philanthropists and reformers among whom William Wilberforce was the leading figure, and Sir Thomas Bernard, Treasurer of the Foundling Hospital, one of the most active members. The focus of their activities was the Society for Bettering the Condition and Increasing the Comforts of the Poor, and to this Society Rumford submitted his proposals for a new scientific institution in London, designed to improve the lot of the poor and the working classes by the application of science to useful purposes.It was decided to make an appeal for funds, Rumford's proposals were circulated, and the Count succeeded in interesting the President of the Royal Society, Sir Joseph Banks, who took the Chair at the early meetings and allowed them to be held at his house, 32 Soho Square. At a meeting held there on 7 March 1799, the new institution was formed by resolution of the subscribers of 50 guineas each, who became the first Proprietors of the Royal Institution of Great Britain, as it was afterwards named in its Royal Charter.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    The @British journal for the history of science 2 (1964), S. 99-115 
    ISSN: 0007-0874
    Source: Cambridge Journals Digital Archives
    Topics: History , Natural Sciences in General
    Notes: AbstractThe paper covers a period of little more than two years in the early history of the Royal Institution, but it is the period in which the house in Albemarle Street was purchased and Count Rumford devoted all his energies to establishing in it the Institution he had conceived. The house was enlarged and adapted to its new purpose; at first a temporary and later the well-known lecture theatre were built. The first Resident Professor and lecturer in the new theatre was Thomas Garnett, whose brief and unhappy connection with the Royal Institution is recorded.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Cambridge : Cambridge University Press
    The @British journal for the history of science 2 (1964), S. 177-179 
    ISSN: 0007-0874
    Source: Cambridge Journals Digital Archives
    Topics: History , Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 6
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    AGU (American Geophysical Union) | Wiley
    In:  Geophysical Research Letters, 44 (9). pp. 4246-4255.
    Publication Date: 2020-02-06
    Description: While the Earth's surface has considerably warmed over the past two decades, the tropical Pacific has featured a cooling of sea surface temperatures in its eastern and central parts, which went along with an unprecedented strengthening of the equatorial trade winds, the surface component of the Pacific Walker Circulation (PWC). Previous studies show that this decadal trend in the trade winds is generally beyond the range of decadal trends simulated by climate models when forced by historical radiative forcing. There is still a debate on the origin of and the potential role that internal variability may have played in the recent decadal surface wind trend. Using a number of long control (unforced) integrations of global climate models and several observational data sets, we address the question as to whether the recent decadal to multidecadal trends are robustly classified as an unusual event or the persistent response to external forcing. The observed trends in the tropical Pacific surface climate are still within the range of the long-term internal variability spanned by the models but represent an extreme realization of this variability. Thus, the recent observed decadal trends in the tropical Pacific, though highly unusual, could be of natural origin. We note that the long-term trends in the selected PWC indices exhibit a large observational uncertainty, even hindering definitive statements about the sign of the trends.
    Type: Article , PeerReviewed , info:eu-repo/semantics/article
    Format: text
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  • 7
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    Wiley | AGU (American Geophysical Union)
    In:  Journal of Geophysical Research: Oceans, 124 (4). pp. 2404-2417.
    Publication Date: 2022-01-31
    Description: The interaction between the atmosphere, specifically the North Atlantic Oscillation (NAO), and the North Atlantic ocean circulation on sub‐decadal timescale is analyzed in a subset of models participating in the Coupled Model Intercomparison Project phase 5 (CMIP5). From preindustrial control runs of at least 500 years length, we derive anomaly patterns in the atmospheric and ocean circulation and of air‐sea heat exchange. All models simulate a distinct dipolar oceanic overturning anomaly at the sub‐decadal timescale, with centers at 30° N and 55° N. The dipolar overturning anomaly goes along with marked anomalies in the North Atlantic sea surface temperature and gyre circulation. Lag‐regression analyses demonstrate, with relatively small ensemble spread, how the atmosphere and the ocean circulation interact. The dipolar anomalies in the overturning are forced by NAO‐related wind stress curl anomalies. Anomalous surface heat fluxes in concert with anomalous vertical motions drive a meridional dipolar heat content anomaly in the upper ocean, and it is this dipolar heat content anomaly which carries the coupled system from one phase of the sub‐decadal cycle to the other by reversing the tendencies in the overturning circulation. The coupled sub‐decadal variability derived from the CMIP5 models is characterized by three elements: a wind‐driven part steering the dipolar overturning anomaly, surface heat flux anomalies that support a heat build‐up in the subpolar gyre region, and the heat storage memory which is instrumental in the phase reversal of the NAO.
    Type: Article , PeerReviewed
    Format: text
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  • 8
    Publication Date: 2015-04-12
    Description: Article HIV vaccine development will be facilitated by having animal models that are predictive for translation to humans. Here, the authors use two nonhuman primate models to compare the effects of natural infection and different adjuvants on antigen persistence, diversity and humoral immunity. Nature Communications doi: 10.1038/ncomms7565 Authors: Joseph R. Francica, Zizhang Sheng, Zhenhai Zhang, Yoshiaki Nishimura, Masashi Shingai, Akshaya Ramesh, Brandon F. Keele, Stephen D. Schmidt, Barbara J. Flynn, Sam Darko, Rebecca M. Lynch, Takuya Yamamoto, Rodrigo Matus-Nicodemos, David Wolinsky, Martha Nason, Nicholas M. Valiante, Padma Malyala, Ennio De Gregorio, Susan W. Barnett, Manmohan Singh, Derek T. O’Hagan, Richard A. Koup, John R. Mascola, Malcolm A. Martin, Thomas B. Kepler, Daniel C. Douek, Lawrence Shapiro, Robert A. Seder
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
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  • 9
    Publication Date: 2012-03-28
    Description: Tonic signaling from O2 sensors sets neural circuit activity and behavioral state Nature Neuroscience 15, 581 (2012). doi:10.1038/nn.3061 Authors: Karl Emanuel Busch, Patrick Laurent, Zoltan Soltesz, Robin Joseph Murphy, Olivier Faivre, Berthold Hedwig, Martin Thomas, Heather L Smith & Mario de Bono
    Print ISSN: 1097-6256
    Electronic ISSN: 1546-1726
    Topics: Biology , Medicine
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  • 10
    Publication Date: 2012-12-27
    Description: Nature Genetics 45, 109 (2013). doi:10.1038/ng.2478 Authors: Miao He, Fabio Miyajima, Paul Roberts, Louise Ellison, Derek J Pickard, Melissa J Martin, Thomas R Connor, Simon R Harris, Derek Fairley, Kathleen B Bamford, Stephanie D'Arc, Jon Brazier, Derek Brown, John E Coia, Gill Douce, Dale Gerding, Hee Jung Kim, Tse Hsien Koh, Haru Kato, Mitsutoshi Senoh, Tom Louie, Stephen Michell, Emma Butt, Sharon J Peacock, Nick M Brown, Tom Riley, Glen Songer, Mark Wilcox, Munir Pirmohamed, Ed Kuijper, Peter Hawkey, Brendan W Wren, Gordon Dougan, Julian Parkhill & Trevor D Lawley Epidemic C. difficile (027/BI/NAP1) has rapidly emerged in the past decade as the leading cause of antibiotic-associated diarrhea worldwide. However, the key events in evolutionary history leading to its emergence and the subsequent patterns of global spread remain unknown. Here, we define the global population structure of C. difficile 027/BI/NAP1 using whole-genome sequencing and phylogenetic analysis. We show that two distinct epidemic lineages, FQR1 and FQR2, not one as previously thought, emerged in North America within a relatively short period after acquiring the same fluoroquinolone resistance–conferring mutation and a highly related conjugative transposon. The two epidemic lineages showed distinct patterns of global spread, and the FQR2 lineage spread more widely, leading to healthcare-associated outbreaks in the UK, continental Europe and Australia. Our analysis identifies key genetic changes linked to the rapid transcontinental dissemination of epidemic C. difficile 027/BI/NAP1 and highlights the routes by which it spreads through the global healthcare system.
    Print ISSN: 1061-4036
    Electronic ISSN: 1546-1718
    Topics: Biology , Medicine
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