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  • 1
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    Online Resource
    ROLE OF GAUMUTRA IN THE MANAGEMENT OF OBESITY W.S.R TO STHAULYA: A REVIEW STUDY
    CAB PUBLISHER ; 2019
    In:  International Journal of Medical and Biomedical Studies Vol. 3, No. 3 ( 2019-03-05)
    Details
    In: International Journal of Medical and Biomedical Studies, CAB PUBLISHER, Vol. 3, No. 3 ( 2019-03-05)
    Abstract: Obesity is a common and preventable disease of clinical and public health importance. It is often a major risk factor for the development of several non-communicable diseases, significant disability and premature death. In Ayurveda, Sthaulya is described in all the literatures. Acharya Charaka has described Sthaulya Purusha among one of the AshtaNinditaPurusha. Sthaulyais caused due to Medovriddhi which includes abnormal and excessive accumulation of medadhatu in the body. This is caused by frequent and excessive intake of madhur and snigdhaaahar , lack of physical and mental exercises. These all results into the increase in kaphadoshaand  medodhatu results in the sthaulya. In modern science, Sthaulya can be compared to the obesity. Obesity is one of the metabolic disorders. WHO considers obesity as a Global epidemic and a public health problem. It is estimated that more than 300 million adults are obese and many are overweight. Sthaulya (obesity) is discouraged by the society for social as well as on the medical grounds. Three main causes have been described in modern literature viz. 1) Dietetic, 2) Genetic, 3) Hormonal.  Person of every age and sex is suffering by this widely spreaded epidemic i.e obesity. It is the major chronic disease in developing as well as in developed countries. The line of treatment includes the treatment of Dhatvagnimandya.  In pathogenesis of Sthaulya, KledakaKapha, Samana & Vyana Vayu, Meda (fat /lipid) and Medodhatvagni Mandyata are main responsible factors Keywords: Medodhatu, Obesity, Sthaulyata, Gaumutra.
    Type of Medium: Online Resource
    ISSN: 2589-8698 , 2589-868X
    URL: Article
    DOI: 10.32553/ijmbs.v3i3.134
    Language: Unknown
    Publisher: CAB PUBLISHER
    Publication Date: 2019
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  • 2
    Online Resource
    Online Resource
    Comparison of DNA Sequencing and Multispecific Monoclonal Antibody (Msmab-1) based Immunohistochemical Detection of IDH1/2 Mutation in Acute Myeloid Leukemia Cases.
    CAB PUBLISHER ; 2023
    In:  International Journal of Medical Science And Diagnosis Research Vol. 7, No. 1 ( 2023-03-02)
    Details
    In: International Journal of Medical Science And Diagnosis Research, CAB PUBLISHER, Vol. 7, No. 1 ( 2023-03-02)
    Abstract: Background: The IDH1/2 mutation is an important epigenetic modifier involved in the pathogenesis of AML. It is associated with variable prognosis in AML cases. Lack of proper molecular diagnostic infrastructure and high cost limits the routine use of PCR with sequencing as routine diagnostic methodology. The aim of this study was to find the prevalence of IDH mutation in AML cases using both PCR with sequencing and Immunohistochemistry method. Methods: We evaluated 60 patients registered at KGMU, Lucknow for diagnosis and treatment of AML. PCR followed by sequencing was done. IHC staining of the IDH1/2 mutation was performed on all cases using bone biopsy or clot section (in cases of pediatric AML cases). Results: Out of the total 60 patients of AML 4(6.7%) patients had IDH1R312 mutation and 5(8.3%) Patients had IDH2R172 mutation. IDH2 R140 mutation was not detected in any sample. On immunohistochemistry analysis 10 cases showed positive staining against anti IDH1/2 mutant (R132/R172) antibody, clone MsMab-1 with a sensitivity of 77.8% and specificity of 94.1%. Conclusion: IHC could be an alternative method to direct Sanger sequencing for IDH1/2 mutation detection in AML cases. However, the antibody used in the study is not effective for individual assessment of IDH1 and IDH2 mutation. Keywords: Immunohistochemistry, Sanger sequencing, IDH1/2 Mutation, Acute Myeloid Leukemia
    Type of Medium: Online Resource
    ISSN: 2581-3935 , 2589-7837
    URL: Article
    DOI: 10.32553/ijmsdr.v7i1.974
    Language: Unknown
    Publisher: CAB PUBLISHER
    Publication Date: 2023
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  • 3
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    Online Resource
    PROSPECTIVE ANALYSIS OF PRISCRIPTION PATTERN OF ANTIMICROBIAL THERAPY FOR URINARY TRACT INFECTIONS IN PREGNANT FEMALE PATIENT
    CAB PUBLISHER ; 2021
    In:  International Journal of Pharmaceutical and Biological Science Archive Vol. 9, No. 1 ( 2021-02-14)
    Details
    In: International Journal of Pharmaceutical and Biological Science Archive, CAB PUBLISHER, Vol. 9, No. 1 ( 2021-02-14)
    Abstract: Pregnancy is a state of relative immunocompromise. This immunocompromise may be another cause for the increased frequency of UTIs seen in pregnancy. UTIs are one of the most common medical complications of pregnancy. Urinary tract infections (UTI) in pregnancy are a large and under-emphasized risk factor for pregnancy morbidity and adverse birth outcomes in low- and middle-income country. A prospective, single centric, observational and descriptive type hospital based study was conducted at the Gynecology Department of a tertiary care hospital for a period of 9 months. This prospective analysis comprises the prevalence of UTI in 53 pregnant female patients with study of their antibiotic   prescription pattern. this present prospective study shows that the prevalence rate of urinary tract infection in pregnancy is 26.5%.(53 UTI cases out of screened 200 patients) Controversially, many literature reviewed showed that in pregnant women’s UTI incidence can be as high as 8 to 20%. Present study indicates the incidence of UTI in pregnancy in relation to gestation period shows that max. UTI patients are from second Trimester (55%) in comparison to first trimester (28%). Least rate of UTI incidence was in Third trimester (17%) due to clinical supervision of pregnant females from starting of gestation. Observation indicates incidence of UTI in relation to age groups under three gestation periods, max. UTI patients were under age group 21 to 30 years of all gestation periods. In first trimester, Second Trimester and third trimester there were 68%, 62% and 56% respectively UTI patients were under age group 21-30 years. This prevalence was due to physiological changes that occur majorly in second trimester. Incidence of UTI pregnant patients under age group 〈 20 years was more in both 1st and 3rd trimester than under age group 〉 30 years. These findings indicate that no relationship exists between age and incidence of UTI in pregnancy. Urinary Tract Infections are confirmed on the basis of bacteriuria present. Urinary tract infections are generally uncomplicated in non pregnant females but becomes complicated in pregnancy specially when left untreated. Present study showed incidence of uncomplicated urithritis and cystitis (65%) and  No complicated UTI cases (pyelonephritis). Gestation distribution of uncomplicated UTI patients showed that max. urithritis(38%) was in Present study shows the frequently isolated organism in UTI in pregnancy include species of Enterobacteriaceae especially Escherichia coli and others citrobactor and proteus. Klebsiella was the second (22%) most isolated organism. Cephalosporin’s with more than 90% general susceptibility than fluoroquinolones ( 〈 90%). Average general susceptibility was found with Ampicillin and sulphonamides.  fluoroquinolones was also alternative choices. All antibiotic prescription was based on antibiotic sensitivity to culture organism. Present study shows max UTI patients of 1st trimester received Nitrofurantoin (47%) as a monotherapy. Due to Antibiotic sensitivity to cultural organism, ciphalosporins and fluoroquinolones was also prescribed as monotherapy. Only single UTI pregnant patient shows sensitivity to cotrimoxazole in first trimester. Cotrimoxazole was prescribed with folic acid supplement. As a safe nonteratogenic drug nitrofurantoin was prescribed to max patients with others drugs in combination. Phenazopyridine an urinary analgesic also prescribed in max. number in combination with nitrofurantoin. Data analysis of observation of 2nd trimester showed that higher percent distribution of patients were received Nitrofurantoin with other drug combinations. Max. no of patients (75%) received Nitrofurantoin with phenazopyridine in comparision to other urinary antibiotics. Patients with Vit.B12 deficiency were also receiving Nitofurantoin with folic acid supplement. Only single Hypertensive pregnant received Methyldopa with ciphalosporins. Only single case of gestational diabetes received nitrofurantoin with glibenclamide  with safer indication. Nitrofurantoin was again highly prescribed urinary antibiotic drug with other drug combination. Present study revealed in 3rd trimester fluoroquinolones were better treatment options with other drugs combination. All pregnant female patients with or without Comorbid conditions received fluoroquinolones. Keywords: fluoroquinolones, Nitrofurantoin
    Type of Medium: Online Resource
    ISSN: 2349-2678 , 2349-2678
    URL: Article
    DOI: 10.32553/ijpba.v9i1.177
    Language: Unknown
    Publisher: CAB PUBLISHER
    Publication Date: 2021
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