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  • British Editorial Society of Bone & Joint Surgery  (13)
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  • British Editorial Society of Bone & Joint Surgery  (13)
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  • 1
    Online Resource
    Online Resource
    HYPERSENSITIVITY IN ASEPTIC LOOSENING OF TOTAL HIP REPLACEMENTS : THE ROLE OF CONSTITUENTS OF BONE CEMENT
    British Editorial Society of Bone & Joint Surgery ; 1996
    In:  The Journal of Bone and Joint Surgery. British volume Vol. 78-B, No. 4 ( 1996-07), p. 546-549
    Details
    In: The Journal of Bone and Joint Surgery. British volume, British Editorial Society of Bone & Joint Surgery, Vol. 78-B, No. 4 ( 1996-07), p. 546-549
    Abstract: Aseptic loosening is seen in a significant proportion of cemented total hip replacements (THR). In a small subgroup of patients who suffer early loosening polyethylene debris is unlikely to be responsible. We recently reported one case of allergic contact dermatitis to N,N-dimethylparatoluidine (DMT), an accelerator used in bone cement. We have therefore investigated this using skin-patch tests to a variety of substances including metals, polyethylene and the separated individual components of Simplex cement. We studied 70 patients, 15 with aseptic loosening less than two years after THR, 25 with satisfactory long-term cemented fixation, five with infected loosening of cemented THRs and 25 awaiting hip arthroplasty. We found seven positive reactions to DMT, all of them in patients with the rapid onset of aseptic loosening. Allergy to DMT is recognised in the dental profession in respect of the ‘denture sore mouth’ syndrome, and could also be an occupational hazard since some industrial glues contain DMT. Our results suggest the need for awareness of possible previous dental or occupational exposure to the constituents of bone cement. We recommend the use of skin-patch testing in high-risk cases.
    Type of Medium: Online Resource
    ISSN: 0301-620X , 2044-5377
    URL: Article
    DOI: 10.1302/0301-620X.78B4.0780546
    RVK:
    XA 52200.B
    Language: English
    Publisher: British Editorial Society of Bone & Joint Surgery
    Publication Date: 1996
    detail.hit.zdb_id: 2697480-0
    detail.hit.zdb_id: 2039886-4
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    Online Resource
  • 2
    Online Resource
    Online Resource
    The culture of articular chondrocytes in hydrogel constructs within a bioreactor enhances cell proliferation and matrix synthesis
    British Editorial Society of Bone & Joint Surgery ; 2006
    In:  The Journal of Bone and Joint Surgery. British volume Vol. 88-B, No. 4 ( 2006-04), p. 544-553
    Details
    In: The Journal of Bone and Joint Surgery. British volume, British Editorial Society of Bone & Joint Surgery, Vol. 88-B, No. 4 ( 2006-04), p. 544-553
    Abstract: Bovine and human articular chondrocytes were seeded in 2% alginate constructs and cultured for up to 19 days in a rotating-wall-vessel (RWV) and under static conditions. Culture within the RWV enhanced DNA levels for bovine chondrocyte-seeded constructs when compared with static conditions but did not produce enhancement for human cells. There was a significant enhancement of glycosaminoglycans and hydroxyproline synthesis for both bovine and human chondrocytes. In all cases, histological analysis revealed enhanced Safranin-O staining in the peripheral regions of the constructs compared with the central region. There was an overall increase in staining intensity after culture within the RWV compared with static conditions. Type-II collagen was produced by both bovine and human chondrocytes in the peripheral and central regions of the constructs and the staining intensity was enhanced by culture within the RWV. A capsule of flattened cells containing type-I collagen developed around the constructs maintained under static conditions when seeded with either bovine or human chondrocytes, but not when cultured within the RWV bioreactor.
    Type of Medium: Online Resource
    ISSN: 0301-620X , 2044-5377
    URL: Article
    DOI: 10.1302/0301-620X.88B4.16498
    RVK:
    XA 52200.B
    Language: English
    Publisher: British Editorial Society of Bone & Joint Surgery
    Publication Date: 2006
    detail.hit.zdb_id: 2697480-0
    detail.hit.zdb_id: 2039886-4
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    Online Resource
  • 3
    Online Resource
    Online Resource
    A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee
    British Editorial Society of Bone & Joint Surgery ; 2003
    In:  The Journal of Bone and Joint Surgery. British volume Vol. 85-B, No. 2 ( 2003-03), p. 223-230
    Details
    In: The Journal of Bone and Joint Surgery. British volume, British Editorial Society of Bone & Joint Surgery, Vol. 85-B, No. 2 ( 2003-03), p. 223-230
    Abstract: Autologous chondrocyte implantation (ACI) and mosaicplasty are both claimed to be successful for the repair of defects of the articular cartilage of the knee but there has been no comparative study of the two methods. A total of 100 patients with a mean age of 31.3 years (16 to 49) and with a symptomatic lesion of the articular cartilage in the knee which was suitable for cartilage repair was randomised to undergo either ACI or mosaicplasty; 58 patients had ACI and 42 mosaicplasty. Most lesions were post-traumatic and the mean size of the defect was 4.66 cm 2 . The mean duration of symptoms was 7.2 years and the mean number of previous operations, excluding arthroscopy, was 1.5. The mean follow-up was 19 months (12 to 26). Functional assessment using the modified Cincinatti and Stanmore scores and objective clinical assessment showed that 88% had excellent or good results after ACI compared with 69% after mosaicplasty. Arthroscopy at one year demonstrated excellent or good repairs in 82% after ACI and in 34% after mosaicplasty. All five patellar mosaicplasties failed. Our prospective, randomised, clinical trial has shown significant superiority of ACI over mosaicplasty for the repair of articular defects in the knee. The results for ACI are comparable with those in other studies, but those for mosaicplasty suggest that its continued use is of dubious value.
    Type of Medium: Online Resource
    ISSN: 0301-620X , 2044-5377
    URL: Article
    DOI: 10.1302/0301-620X.85B2.13543
    RVK:
    XA 52200.B
    Language: English
    Publisher: British Editorial Society of Bone & Joint Surgery
    Publication Date: 2003
    detail.hit.zdb_id: 2697480-0
    detail.hit.zdb_id: 2039886-4
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    Online Resource
  • 4
    Online Resource
    Online Resource
    The treatment of scoliosis in muscular dystrophy using modified Luque and Harrington-Luque instrumentation
    British Editorial Society of Bone & Joint Surgery ; 2001
    In:  The Journal of Bone and Joint Surgery Vol. 83, No. 1 ( 2001-1-1), p. 22-28
    Details
    In: The Journal of Bone and Joint Surgery, British Editorial Society of Bone & Joint Surgery, Vol. 83, No. 1 ( 2001-1-1), p. 22-28
    Type of Medium: Online Resource
    ISSN: 0000-0000 , 0301-620X
    URL: Article
    DOI: 10.1302/0301-620X.83B1.10029
    RVK:
    XA 52200.B
    Language: Unknown
    Publisher: British Editorial Society of Bone & Joint Surgery
    Publication Date: 2001
    detail.hit.zdb_id: 2697480-0
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    Online Resource
  • 5
    Online Resource
    Online Resource
    Spinal Cord Monitoring In Operations For Neuromuscular Scoliosis
    British Editorial Society of Bone & Joint Surgery ; 1997
    In:  The Journal of Bone and Joint Surgery Vol. 79, No. 1 ( 1997-1-1), p. 53-57
    Details
    In: The Journal of Bone and Joint Surgery, British Editorial Society of Bone & Joint Surgery, Vol. 79, No. 1 ( 1997-1-1), p. 53-57
    Type of Medium: Online Resource
    ISSN: 0000-0000 , 0301-620X
    URL: Article
    DOI: 10.1302/0301-620X.79B1.6699
    RVK:
    XA 52200.B
    Language: Unknown
    Publisher: British Editorial Society of Bone & Joint Surgery
    Publication Date: 1997
    detail.hit.zdb_id: 2697480-0
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    Online Resource
  • 6
    Online Resource
    Online Resource
    SPINAL CORD MONITORING IN OPERATIONS FOR NEUROMUSCULAR SCOLIOSIS
    British Editorial Society of Bone & Joint Surgery ; 1997
    In:  The Journal of Bone and Joint Surgery. British volume Vol. 79-B, No. 1 ( 1997-01), p. 53-57
    Details
    In: The Journal of Bone and Joint Surgery. British volume, British Editorial Society of Bone & Joint Surgery, Vol. 79-B, No. 1 ( 1997-01), p. 53-57
    Abstract: We reviewed retrospectively the role of monitoring of somatosensory spinal evoked potentials (SSEP) in 99 patients with neuromuscular scoliosis who had had operative correction with Luque-Galveston rods and sublaminar wiring. Our findings showed that SSEP monitoring was useful and that a 50% decrease in the amplitude of the trace optimised both sensitivity and specificity. The detection of true-positive results was higher than in cases of idiopathic scoliosis, but the method was less sensitive and specific and there were more false-negative results. In contrast with the findings in idiopathic scoliosis, recovery of the trace was associated with a 50% to 60% risk of neurological impairment. Only one permanent injury occurred during the use of this technique, and any temporary impairment resolved within two months.
    Type of Medium: Online Resource
    ISSN: 0301-620X , 2044-5377
    URL: Article
    DOI: 10.1302/0301-620X.79B1.0790053
    RVK:
    XA 52200.B
    Language: English
    Publisher: British Editorial Society of Bone & Joint Surgery
    Publication Date: 1997
    detail.hit.zdb_id: 2697480-0
    detail.hit.zdb_id: 2039886-4
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    Online Resource
  • 7
    Online Resource
    Online Resource
    Who is the ideal candidate for autologous chondrocyte implantation?
    British Editorial Society of Bone & Joint Surgery ; 2006
    In:  The Journal of Bone and Joint Surgery. British volume Vol. 88-B, No. 1 ( 2006-01), p. 61-64
    Details
    In: The Journal of Bone and Joint Surgery. British volume, British Editorial Society of Bone & Joint Surgery, Vol. 88-B, No. 1 ( 2006-01), p. 61-64
    Abstract: We investigated the prognostic indicators for collagen-covered autologous chondrocyte implantation (ACI-C) performed for symptomatic osteochondral defects of the knee. We analysed prospectively 199 patients for up to four years after surgery using the modified Cincinnati score. Arthroscopic assessment and biopsy of the neocartilage was also performed whenever possible. The favourable factors for ACI-C include younger patients with higher pre-operative modified Cincinnati scores, a less than two-year history of symptoms, a single defect, a defect on the trochlea or lateral femoral condyle and patients with fewer than two previous procedures on the index knee. Revision ACI-C in patients with previous ACI and mosaicplasties which had failed produced significantly inferior clinical results. Gender (p = 0.20) and the size of the defect (p = 0.97) did not significantly influence the outcome.
    Type of Medium: Online Resource
    ISSN: 0301-620X , 2044-5377
    URL: Article
    DOI: 10.1302/0301-620X.88B1.16796
    RVK:
    XA 52200.B
    Language: English
    Publisher: British Editorial Society of Bone & Joint Surgery
    Publication Date: 2006
    detail.hit.zdb_id: 2697480-0
    detail.hit.zdb_id: 2039886-4
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    Online Resource
  • 8
    Online Resource
    Online Resource
    Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee : A PROSPECTIVE, RANDOMISED STUDY
    British Editorial Society of Bone & Joint Surgery ; 2005
    In:  The Journal of Bone and Joint Surgery. British volume Vol. 87-B, No. 5 ( 2005-05), p. 640-645
    Details
    In: The Journal of Bone and Joint Surgery. British volume, British Editorial Society of Bone & Joint Surgery, Vol. 87-B, No. 5 ( 2005-05), p. 640-645
    Abstract: Autologous chondrocyte implantation (ACI) is used widely as a treatment for symptomatic chondral and osteochondral defects of the knee. Variations of the original periosteum-cover technique include the use of porcine-derived type I/type III collagen as a cover (ACI-C) and matrix-induced autologous chondrocyte implantation (MACI) using a collagen bilayer seeded with chondrocytes. We have performed a prospective, randomised comparison of ACI-C and MACI for the treatment of symptomatic chondral defects of the knee in 91 patients, of whom 44 received ACI-C and 47 MACI grafts. Both treatments resulted in improvement of the clinical score after one year. The mean modified Cincinnati knee score increased by 17.6 in the ACI-C group and 19.6 in the MACI group (p = 0.32). Arthroscopic assessments performed after one year showed a good to excellent International Cartilage Repair Society score in 79.2% of ACI-C and 66.6% of MACI grafts. Hyaline-like cartilage or hyaline-like cartilage with fibrocartilage was found in the biopsies of 43.9% of the ACI-C and 36.4% of the MACI grafts after one year. The rate of hypertrophy of the graft was 9% (4 of 44) in the ACI-C group and 6% (3 of 47) in the MACI group. The frequency of re-operation was 9% in each group. We conclude that the clinical, arthroscopic and histological outcomes are comparable for both ACI-C and MACI. While MACI is technically attractive, further long-term studies are required before the technique is widely adopted.
    Type of Medium: Online Resource
    ISSN: 0301-620X , 2044-5377
    URL: Article
    DOI: 10.1302/0301-620X.87B5.15905
    RVK:
    XA 52200.B
    Language: English
    Publisher: British Editorial Society of Bone & Joint Surgery
    Publication Date: 2005
    detail.hit.zdb_id: 2697480-0
    detail.hit.zdb_id: 2039886-4
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    Online Resource
  • 9
    Online Resource
    Online Resource
    Collagen-covered autologous chondrocyte implantation for osteochondritis dissecans of the knee : TWO- TO SEVEN-YEAR RESULTS
    British Editorial Society of Bone & Joint Surgery ; 2006
    In:  The Journal of Bone and Joint Surgery. British volume Vol. 88-B, No. 2 ( 2006-02), p. 203-205
    Details
    In: The Journal of Bone and Joint Surgery. British volume, British Editorial Society of Bone & Joint Surgery, Vol. 88-B, No. 2 ( 2006-02), p. 203-205
    Abstract: We prospectively studied the clinical, arthroscopic and histological results of collagen-covered autologous chondrocyte implantation (ACI-C) in patients with symptomatic osteochondritis dissecans of the knee. The study included 37 patients who were evaluated at a mean follow-up of 4.08 years. Clinical results showed a mean improvement in the modified Cincinnati score from 46.1 to 68.4. Excellent and good clinical results were seen in 82.1% of those with juvenile-onset osteochondritis dissecans but in only 44.4% of those with adult-onset disease. Arthroscopy at one year revealed International Cartilage Repair Society grades of 1 or 2 in 21 of 24 patients (87.5%). Of 23 biopsies, 11 (47.8%) showed either a hyaline-like or a mixture of hyaline-like and fibrocartilage, 12 (52.2%) showed fibrocartilage. The age at the time of ACI-C determined the clinical outcome for juvenile-onset disease (p = 0.05), whereas the size of the defect was the major determinant of outcome in adult-onset disease (p = 0.01).
    Type of Medium: Online Resource
    ISSN: 0301-620X , 2044-5377
    URL: Article
    DOI: 10.1302/0301-620X.88B2.17009
    RVK:
    XA 52200.B
    Language: English
    Publisher: British Editorial Society of Bone & Joint Surgery
    Publication Date: 2006
    detail.hit.zdb_id: 2697480-0
    detail.hit.zdb_id: 2039886-4
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    Online Resource
  • 10
    Online Resource
    Online Resource
    PROCEEDINGS AND REPORTS OF UNIVERSITIES COLLEGES, COUNCILS AND ASSOCIATIONS
    British Editorial Society of Bone & Joint Surgery ; 1974
    In:  The Journal of Bone and Joint Surgery. British volume Vol. 56-B, No. 4 ( 1974-11), p. 768-778
    Details
    In: The Journal of Bone and Joint Surgery. British volume, British Editorial Society of Bone & Joint Surgery, Vol. 56-B, No. 4 ( 1974-11), p. 768-778
    Type of Medium: Online Resource
    ISSN: 0301-620X , 2044-5377
    URL: Article
    DOI: 10.1302/0301-620X.56B4.768
    RVK:
    XA 52200.B
    Language: English
    Publisher: British Editorial Society of Bone & Joint Surgery
    Publication Date: 1974
    detail.hit.zdb_id: 2697480-0
    detail.hit.zdb_id: 2039886-4
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