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  • 1
    Online Resource
    Online Resource
    Relationship between levels of physical activity and brain derived neurotrophic factor in peripheral blood of monozygotic twins
    Brill ; 2020
    In:  Comparative Exercise Physiology Vol. 16, No. 4 ( 2020-07-1), p. 319-324
    Details
    In: Comparative Exercise Physiology, Brill, Vol. 16, No. 4 ( 2020-07-1), p. 319-324
    Abstract: Studies involving monozigotic (MZ) twins are of great importance for the understanding of genetic and environmental influences without the development of individual pathologies and pathways associated with lifestyle. In this context, discordance has recently been suggested in the levels of the brain-derived neurotrophic factor (BDNF) in MZ twins, which may be associated with the practice of physical activity (PA). The objective was to verify the relationship between the peripheral levels of BDNF and PA in MZ twins. This transversal and quantitative study included 11 pairs of MZ twins that answered the International Physical Activity Questionnaire (IPAQ), a brief anamnesis and were submitted to a blood collection (15 ml) for BDNF levels analysis, measured through ELISA kit according to the manufacturer’s instructions. The study was approved by the Ethics Committee of Centro Universitário Metodista IPA (no. 1.746.954). There was no statistically significant relationship between BDNF and PA levels in sedentary and physically active MZ twins ( P =0.431). PA practice does not seem to influence BDNF levels in these individuals.
    Type of Medium: Online Resource
    ISSN: 1755-2540 , 1755-2559
    URL: Article
    DOI: 10.3920/CEP190061
    Language: Unknown
    Publisher: Brill
    Publication Date: 2020
    SSG: 22
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  • 2
    Online Resource
    Online Resource
    Exercise reduced the concentration of an inflammatory makers without modulating the levels of epigenetic marker potentially involved in hypertension: a preliminary study
    Brill ; 2023
    In:  Comparative Exercise Physiology Vol. 19, No. 3 ( 2023-09-20), p. 197-206
    Details
    In: Comparative Exercise Physiology, Brill, Vol. 19, No. 3 ( 2023-09-20), p. 197-206
    Abstract: Epigenetic mechanisms such as histone acetylation status mediated by HAT and HDAC2 enzymes play a central role in the pathophysiology, etiology, and progression of hypertension. The anti-inflammatory effects of physical exercise may be related to the modulation of histone acetylation status, which may alter the epigenome, providing therapeutic benefits for hypertensive individuals. To investigate the effects of an exercise training protocol on epigenetic parameters (HAT activities and HDAC2 concentrations), inflammatory markers (interleukin (IL)-10, tumour necrosis factor (TNF)-α, and C-reactive protein (CRP)), and cardiopulmonary fitness parameters (VO 2peak , ambulatory blood pressure, NOx, endothelin 1 (ET-1), flow-mediated dilation, high density lipoprotein (HDL), and triacylglycerol levels) in treated hypertensive patients. Nine hypertensive patients aged 30-59 years underwent 12 weeks of strength or aerobic exercise 3 times a week. Physical fitness, 24-h blood pressure (systolic and diastolic), flow-mediated vasodilation, blood lipid profile analysis, and biomarkers were assessed before and after the intervention. No alterations were found in epigenetic parameters since HAT activities and HDAC2 concentrations remained unchanged after the intervention. Significant increases were found in VO 2peak (pre: 29.1±6.3 and post: 31.5±6.3, P =0.021) and HDL (pre: 41.4±9 and post: 46.8±9.5, P =0.003). Furthermore, a significant reduction was seen in 24-h systolic and diastolic blood pressure, respectively: (pre: 119.1±5.6 and post: 114.4±4.5, P =0.6; pre: 73.9±4.1 and post: 70.5±4.2, P =0.4) and in CRP (pre: 2.4±1.4; post: 1.2±0.7*, P =0.03). Lastly, no alterations were found in IL-10 and TNF-α. In treated hypertensive individuals undergoing 12 weeks of exercise training VO 2peak , 24 h blood pressure, HDL, and CRP improved. However, changes were not found in concentrations and the activity of HDAC2 and HAT, respectively.
    Type of Medium: Online Resource
    ISSN: 1755-2540 , 1755-2559
    URL: Article
    DOI: 10.3920/CEP220037
    Language: Unknown
    Publisher: Brill
    Publication Date: 2023
    SSG: 22
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  • 3
    Online Resource
    Online Resource
    Acute and chronic non-invasive radiofrequency intervention modulates inflammatory but non epigenetic makers in physically active women
    Brill ; 2020
    In:  Comparative Exercise Physiology Vol. 16, No. 3 ( 2020-03-23), p. 169-178
    Details
    In: Comparative Exercise Physiology, Brill, Vol. 16, No. 3 ( 2020-03-23), p. 169-178
    Abstract: The non-invasive radiofrequency (RF) intervention has been demonstrating to improve anthropometric variables in women. However, the molecular mechanisms involved in this response were not elucidated. This study aimed verify the effect of RF on anthropometric measurements, inflammatory cytokines (interleukin (IL)-1β, IL-1ra, monocyte chemoattractant protein type 1 (MCP-1)) and global histone H4 acetylation levels in the peripheral blood of healthy women. The volunteers were divided in sedentary (SED) and physically active (PA) groups and submitted to the intervention (4 sessions, 1 time per week). Blood samples were collected before (T1), after the first session (T2) and after the last session (T3). The anthropometric measures were checked before and after the intervention. A significant reduction in body mass and adipose mass was observed in the PA group at T3 when compared to T1; while reductions in supra-iliac and abdominal skinfolds and abdominal circumference were found in SED and PA groups after intervention. The PA group presented greater reductions in supra-iliac skinfold and abdominal circumference at T3 when compared to the SED group. The intervention did not alter IL-1β and IL-1ra and global histone H4 acetylation levels in both groups. A significant increase in MCP-1 levels was found at T3 compared to T1 in the SED group. In the PA group, a reduction in MCP-1 levels was observed at T2 compared to T1. However, there was an increase in this marker at T3 compared to T1. Non-invasive RF improved anthropometric measurements with more pronounced effects in the PA and this response might involve the modulation of MCP-1.
    Type of Medium: Online Resource
    ISSN: 1755-2540 , 1755-2559
    URL: Article
    DOI: 10.3920/CEP190043
    Language: Unknown
    Publisher: Brill
    Publication Date: 2020
    SSG: 22
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  • 4
    Online Resource
    Online Resource
    Does a HIIT modulate BDNF levels, and epigenetic and muscle damage markers in postmenopausal obese women?
    Brill ; 2019
    In:  Comparative Exercise Physiology Vol. 15, No. 4 ( 2019-10-9), p. 243-251
    Details
    In: Comparative Exercise Physiology, Brill, Vol. 15, No. 4 ( 2019-10-9), p. 243-251
    Abstract: Recent clinical studies demonstrated that single bouts of exercise including high intensity interval training (HIIT) protocols are able to modulate muscle damage and epigenetic markers as well as brain-derived neurotrophic factor (BDNF) levels in different populations, however, this relationship is lacking in obese women. To evaluate the impact of a single bout of HIIT on creatine kinase (CK), BDNF and global histone H3 and H4 acetylation levels in obese postmenopausal women. The sample consisted of 10 volunteers with a body mass index of 27 to 39.9 kg / m 2 that were submitted to a single session of HIIT on a cycle ergometer for 60 s (separated by 75 s of active recovery). In order to measure the biomarkers, blood samples (15 ml) were collected immediately before and immediately after the intervention. Our protocol did not modify any biomarkers ( P 〉 0.05), although a negative correlation between fat mass and global histone H3 levels ( P =0.022) and between oxygen consumption and global histone H4 levels ( P =0.003) were found. A single bout of HIIT on a cycle ergometer is not an effective strategy to modulate histone acetylation status, CK and BDNF levels in postmenopausal obese women. Future studies considering different exercise protocols should be done in order to elucidate this issue.
    Type of Medium: Online Resource
    ISSN: 1755-2540 , 1755-2559
    URL: Article
    DOI: 10.3920/CEP190026
    Language: Unknown
    Publisher: Brill
    Publication Date: 2019
    SSG: 22
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  • 5
    Online Resource
    Online Resource
    Grape juice consumption-induced physical functional performance improvement alone or combined with therapeutic exercise in elderly women
    Brill ; 2019
    In:  Comparative Exercise Physiology Vol. 15, No. 2 ( 2019-06-18), p. 95-104
    Details
    In: Comparative Exercise Physiology, Brill, Vol. 15, No. 2 ( 2019-06-18), p. 95-104
    Abstract: This study aimed to examine the effects of grape juice consumption during 4 weeks alone or combined with a therapeutic exercise protocol on quality of life (SF-36), handgrip strength (dynamometry) and physical function performance evaluated through Berg Balance Scale (BBS), Timed Up and Go, Six-Minute Walk Test (6MWT) in elderly women. Nineteen healthy elderly women were distributed in Grape Juice Group (GJG, n=9) and Grape Juice + Exercise Group (GJEG, n=10). A significant improvement in handgrip strength and BBS were observed in GJG. Both groups showed increased values in 6MWT and the quality of life was significantly improved after intervention in GJEG. Daily grape juice consumption is able to improve some physical functional parameters in elderly women; however, when in combination with therapeutic exercise intervention may provide a more effective strategy to positively affect the quality of life.
    Type of Medium: Online Resource
    ISSN: 1755-2540 , 1755-2559
    URL: Article
    DOI: 10.3920/CEP190027
    Language: Unknown
    Publisher: Brill
    Publication Date: 2019
    SSG: 22
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  • 6
    Online Resource
    Online Resource
    Effects of Qigong practice in quality of life, fatigue, sleep, pain and epigenetic biomarkers in adult women with fibromyalgia
    Brill ; 2020
    In:  Comparative Exercise Physiology Vol. 16, No. 4 ( 2020-07-1), p. 285-292
    Details
    In: Comparative Exercise Physiology, Brill, Vol. 16, No. 4 ( 2020-07-1), p. 285-292
    Abstract: Fibromyalgia is a syndrome mainly diagnosed through patient medical history. These individuals may present symptoms, such as sleeping disorders, migraines, and widespread pain through the musculoskeletal system, resulting in less quality of life. Treatment for fibromyalgia is based on pharmacological and non-pharmacological options. Mind-body practices, such as Baduanjin Qigong, have been described as promising alternatives to better multiple symptoms presented by individuals with the condition. Searching for non-pharmacological alternatives that significantly increase the quality of life of these individuals, this study evaluates the alterations in epigenetic markers in short- and long-term after the practice of Baduanjin Qigong. The participants took part in presential sessions of Baduanjin Qigong twice a week for 8 weeks, as well as being encouraged to practice at home for 4 weeks. The evaluation of the biomarkers was made through the collection of blood samples before the first session, after the sessions in person and after the 4 weeks of practice at home. Fatigue, sleep quality and chronic pain were evaluated before the first sessions and at the end of the process, through the application of self-reported instruments: Fibromyalgia Impact Questionnaire (FIQ), Functional Assessment of Chronic Illness-Fatigue (FACIT), Pittsburgh Sleep Quality Index (PSQI) and Multidimensional Pain Evaluation Scale (EMADOR). As a result, significant improvements were found in quality of life, and in the symptoms of fatigue, sleep disturbance and in chronic pain in some regions of the body. In spite of the clinical-functional improvements, no significant alterations were found in the activity of histone acetyltransferase (HAT) enzymes after the intervention. The practice of Qigong approved to be a good alternative to improve the main symptoms of fibromyalgia in women, without involving modulation of HAT activity.
    Type of Medium: Online Resource
    ISSN: 1755-2540 , 1755-2559
    URL: Article
    DOI: 10.3920/CEP190072
    Language: Unknown
    Publisher: Brill
    Publication Date: 2020
    SSG: 22
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  • 7
    Online Resource
    Online Resource
    Time course of epigenetic modulation in response to concurrent exercise training in patients with schizophrenia
    Brill ; 2022
    In:  Comparative Exercise Physiology Vol. 18, No. 4 ( 2022-09-2), p. 281-288
    Details
    In: Comparative Exercise Physiology, Brill, Vol. 18, No. 4 ( 2022-09-2), p. 281-288
    Abstract: This study aimed to investigate the short and long-term effects of concurrent exercise training on anthropometric variables, HDCA2 activity and cortisol levels of individuals with schizophrenia (SZ). Therefore, 10 patients were submitted to the program (endurance and strength exercises in the same session, 60 min of duration, three times a week) and blood samples were collected before, 30 days and 180 days after the intervention started. Exercise training reduced the body mass index and body mass after 180 days of the intervention. A significant decrease on HDAC2 activity was found 180 days after intervention compared to before the intervention. The cortisol levels remained unchanged in any evaluated time-points. The concurrent exercise training was able to modulate HDAC2 activity in mononuclear cells and improve anthropometric variables in a time-dependent manner in patients with SZ.
    Type of Medium: Online Resource
    ISSN: 1755-2540 , 1755-2559
    URL: Article
    DOI: 10.3920/CEP210013
    Language: Unknown
    Publisher: Brill
    Publication Date: 2022
    SSG: 22
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