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  • 1
    Online Resource
    Online Resource
    Experiences and Perspectives of Patients Treated with Methadone on Mental Health Aspect of Lifestyle: A Qualitative Study
    Briefland ; 2022
    In:  Iranian Journal of Psychiatry and Behavioral Sciences Vol. 16, No. 4 ( 2022-12-06)
    Details
    In: Iranian Journal of Psychiatry and Behavioral Sciences, Briefland, Vol. 16, No. 4 ( 2022-12-06)
    Abstract: Background: Drug abuse and its consequences place a considerable social and economic burden on society. Drug abuse has increased in Iran and reached three times the global average, indicating the need to develop innovative strategies to cope with this phenomenon. Objectives: Following a community-based participatory research approach, the aim was to identify the lived experience of drug users regarding the psychological aspect of their lifestyle. Methods: Narrative inquiry and phenomenological design were applied as the research framework. The use of in-depth interviews and field notes guided the data collection and analysis. A total of 26 in-depth interviews were conducted with people who suffered from drug use (7 females and 19 males) in 2021. Interviews ranging from 70 to 90 minutes and conducted in a quiet, private location chosen by the researcher. All interviews were audio-taped and transcribed, and analyzed using Colaizzi's method. Data analysis was administered using MAXQDA version 2020. Results: Most of the participants were educated Diploma and above. The participants' age ranged from 25 to 53 years old. The analysis revealed four themes, and 11 sub-themes emerged. The themes were as follows: (1) negative emotions; (2) poor psychological capital; (3) poor support; and (4) psychological well-being. Conclusions: The most important problems of people with substance use, in the psychological dimension of lifestyle, include experiencing negative emotions, weak psychological capital, weak social support, unhealthy psychological well-being such as negative self-acceptance, reduced positive relations, not having a purposeful life, and inability to control environmental pressures. Hopefully, this study can help health policymakers develop more effective strategies against drug use.
    Type of Medium: Online Resource
    ISSN: 1735-8639 , 1735-9287
    URL: Journal
    URL: Article
    DOI: 10.5812/ijpbs
    DOI: 10.5812/ijpbs-128804
    Language: Unknown
    Publisher: Briefland
    Publication Date: 2022
    detail.hit.zdb_id: 2536256-2
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  • 2
    Online Resource
    Online Resource
    Protective Effects of Coadministration of the Vitamin E and Omega-3 on Doxorubicin-Induced Hepatotoxicity in Mice
    Briefland ; 2022
    In:  International Journal of Cancer Management Vol. 15, No. 10 ( 2022-10-20)
    Details
    In: International Journal of Cancer Management, Briefland, Vol. 15, No. 10 ( 2022-10-20)
    Abstract: Background: Doxorubicin is a favorite drug for feasting many malignancies. All organs' hepatic toxic effects are destructive and lead to use with caution. Then, it is necessary to increase antioxidants accompanied with doxorubicin to reduce its toxicity. Vitamin E is an antioxidant with harmful consequences. Omega-3 is an antioxidant similarly. The healing capacity of Vitamin E- Omega-3 was investigated together against doxorubicin. Methods: Thirty balb/c mice have divided a weight of 25 g into five equal groups of six mice each. The groups were classified as Control: Normal saline; DOX: Doxorubicin; Vitamin E: Vitamin E + DOX; Omega-3; Omega-3 + DOX; Both Vitamin E- Omega-3 + DOX. The histopathology was set to describe vacuolar degeneration, inflammation, and necrosis. Immunohistochemistry was performed to estimate the expression of tumor necrosis factor (TNFα), demonstrating the inflammation. Results: DOX-induced hepatic injury and increased TNF-α expression were seen more than alone when co-administered with vitamin E and omega-3. A significant decrease was shown in the ALT, AST, GGT, and ALP levels compared to the control. The Glutathione peroxidase and Catalase enzyme activities were higher in the co-administered Vitamin E- Omega-3 group than that received Vit E or Omega-3. Conclusions: Co-administration of Vitamin E and Omega-3 have a more repair capacity with controlling effects on Doxorubicin-induced liver toxicity.
    Type of Medium: Online Resource
    ISSN: 2538-4422 , 2538-497X
    URL: Journal
    URL: Article
    DOI: 10.5812/ijcm
    DOI: 10.5812/ijcm-121766
    Language: Unknown
    Publisher: Briefland
    Publication Date: 2022
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  • 3
    Online Resource
    Online Resource
    Potential Risk Factors for Length of Hospitalization in COVID-19 Patients: A Cross-sectional Study
    Briefland ; 2021
    In:  Health Scope Vol. 10, No. 4 ( 2021-12-11)
    Details
    In: Health Scope, Briefland, Vol. 10, No. 4 ( 2021-12-11)
    Abstract: Background: Identifying the potential risk factors of the length of stay in hospital (LOSH) in COVID-19 patients could help the health system meet future demand for hospital beds. Objectives: This study aimed to determine the factors affecting the length of stay in hospital in COVID-19 patients in Hamadan, the west of Iran. Methods: This cross-sectional study recruited 512 hospitalized COVID-19 patients in Hamadan city. Demographic, clinical, and medical laboratory characteristics of the patients and their survival status were assessed by a checklist. Univariate and multiple negative binomial regressions were used by Stata 12. Results: The median hospitalization length for COVID-19 patients was five days (range: 0 to 47). In the discharged patients, the adjusted incidence rate ratios (95% CI) of LOSH for females, rural residents, patients with a history of diabetes and cardiovascular disease, SPO2 less than 88%, prothrombin time higher than 13 s, platelet count lower than 130 × 1000 µL, blood sugar higher than 105 mg/dL, and intensive care unit experience were 1.16 (1.03, 1.44), 1.22 (1.03, 1.44), 1.43 (1.07, 1.92), 1.41 (1.23, 1.61), 0.82 (0.71, 0.93), 1.32 (1.11, 1.56), 1.18 (1.03, 1.36), and 1.85 (1.59, 2.17) compared to their references, respectively. Conclusions: Our study added new insight into LOSH determining factors that could be used for future planning in combating the need for hospital beds. The present study revealed that some demographic, social, and clinical variables could increase the IRR of a more extended hospital stay.
    Type of Medium: Online Resource
    ISSN: 2251-8959 , 2251-9513
    URL: Journal
    URL: Article
    DOI: 10.5812/healthscope
    DOI: 10.5812/jhealthscope.115575
    Language: Unknown
    Publisher: Briefland
    Publication Date: 2021
    detail.hit.zdb_id: 2713439-8
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  • 4
    Online Resource
    Online Resource
    A Review on Stem Cell Therapy in Cerebral Palsy with a Focus on Motor Function Improvement
    Briefland ; 2018
    In:  Archives of Neuroscience Vol. 5, No. 1 ( 2018-01-10)
    Details
    In: Archives of Neuroscience, Briefland, Vol. 5, No. 1 ( 2018-01-10)
    Type of Medium: Online Resource
    ISSN: 2322-3944 , 2322-5769
    URL: Journal
    URL: Article
    DOI: 10.5812/ans
    DOI: 10.5812/archneurosci.59387
    Language: Unknown
    Publisher: Briefland
    Publication Date: 2018
    detail.hit.zdb_id: 2733284-6
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  • 5
    Online Resource
    Online Resource
    Ameliorative Effect of the Combination of the Cichorium intybus Whole Extract and Melatonin on Doxorubicin-induced Hepatotoxicity in Mice
    Briefland ; 2022
    In:  International Journal of Cancer Management Vol. 15, No. 3 ( 2022-06-05)
    Details
    In: International Journal of Cancer Management, Briefland, Vol. 15, No. 3 ( 2022-06-05)
    Abstract: Background: Doxorubicin is anticancer that is a choice for the treatment of many malignancies. The nature of its toxic effects on the liver and other organs is the harmful character that leads to use with caution. Then, it is necessary to supplement an antioxidant with doxorubicin to reduce its side effects. Objectives: Cichorium intybus (C. intybus) is a plant with hepatoprotective effects. Melatonin is an antioxidant similar to vitamins. We investigated the repairing effects of C. intybus -melatonin together against doxorubicin-induced hepatotoxicity. Methods: Thirty balb/c mice in the weight range of 20 g to 25 g were divided into 5 equal groups of 6 animals each. The groups were as Control: normal saline; DOX: doxorubicin; Chicory: chicory whole plant extract + DOX; Melatonin; melatonin + DOX; Both Chicory-Melatonin + DOX. We assessed histopathology to define necrosis, vacuolar degeneration, and inflammation. In addition, we used immunohistochemistry to evaluate the TNFα proving the rate of inflammation. Results: The mean sum of histological grading in the control group was 0.00 in contrast to severe damage of the hepatic parenchyma grading 11.34 in sum. The mean sum grade of the other groups including Chicory, Melatonin, and Both Chicory-Melatonin were 8.17, 4.18, and 2.49, respectively. We found that the increased liver damage and TNF-α expression induced by DOX could be improved by applying therapeutic care with the coadministration of the C. intybus extract and Melatonin. Conclusions: Chicory and Melatonin have a healing ability against doxorubicin-induced hepatic lesions.
    Type of Medium: Online Resource
    ISSN: 2538-4422 , 2538-497X
    URL: Journal
    URL: Article
    DOI: 10.5812/ijcm
    DOI: 10.5812/ijcm-119807
    Language: Unknown
    Publisher: Briefland
    Publication Date: 2022
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  • 6
    Online Resource
    Online Resource
    Role of Public-Private Partnerships in Primary Healthcare Services Worldwide: A Scoping Review
    Briefland ; 2022
    In:  Health Scope Vol. 11, No. 3 ( 2022-09-07)
    Details
    In: Health Scope, Briefland, Vol. 11, No. 3 ( 2022-09-07)
    Abstract: Background: The public health system is currently facing a shortage of resources, and the demand for healthcare has increased, indicating the need to use the capacities of other sectors through public-private partnership (PPP) strategies to improve the quantity and quality of health services. Objectives: The purpose is to identify PPPs' role in providing primary healthcare worldwide. Methods: This study was conducted in 2020. The Arksey O’Malley framework was used, along with a systematic literature search on five databases, including Web of Science (ISI), Scopus, Pubmed, ProQuest, and Google Scholar. Data were gathered from 2000 to 2020. Results: The findings presented in this study are reported based on 16 selected studies. The findings point to the positive impacts of cooperation between the public and private sectors in health care systems on matters of provision, coverage, and performance of services, as well as improvements in responsiveness to providers towards enhancing health referral systems. The provision of participatory services in countries varied according to their level of development, and further interactions between the government and the private sector resulted in better coverage and reduced inequality in service delivery. Conclusions: Public-private partnership is an effective way to achieve sustainable development goals. Public-private partnerships can be strengthened by integrating public and private sector facilities and aligning the interests and motivations of service providers with public health goals. Also, awareness of the plans and capacity of public and private sectors, along with conscious and mutual interaction, can strengthen health on a larger scale. Scientific approaches and correct participation can also relieve the part of governmental responsibilities to focus on more primary measures so that it can carry out its core tasks, including stewardship, policy-making, and supervision, with greater focus and power to facilitate the achievement of goals.
    Type of Medium: Online Resource
    ISSN: 2251-8959 , 2251-9513
    URL: Journal
    URL: Article
    DOI: 10.5812/healthscope
    DOI: 10.5812/jhealthscope-129176
    Language: Unknown
    Publisher: Briefland
    Publication Date: 2022
    detail.hit.zdb_id: 2713439-8
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  • 7
    Online Resource
    Online Resource
    Factors Affecting Fee-Setting for Dental Services in Iran’s Private Sector: Dentists’ Perspective
    Briefland ; 2018
    In:  Shiraz E-Medical Journal Vol. In Press, No. In Press ( 2018-09-08)
    Details
    In: Shiraz E-Medical Journal, Briefland, Vol. In Press, No. In Press ( 2018-09-08)
    Type of Medium: Online Resource
    ISSN: 1735-1391
    URL: Journal
    URL: Article
    DOI: 10.5812/semj
    DOI: 10.5812/semj.74247
    Language: Unknown
    Publisher: Briefland
    Publication Date: 2018
    detail.hit.zdb_id: 2060231-5
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  • 8
    Online Resource
    Online Resource
    Predictive Factors for Ultrasonographic Grading of Non-Alcoholic Fatty Liver Disease
    Briefland ; 2012
    In:  Hepatitis Monthly Vol. 12, No. 11 ( 2012-11-04)
    Details
    In: Hepatitis Monthly, Briefland, Vol. 12, No. 11 ( 2012-11-04)
    Type of Medium: Online Resource
    ISSN: 1735-143X , 1735-3408
    URL: Journal
    URL: Article
    DOI: 10.5812/hepatmon
    DOI: 10.5812/hepatmon.6860
    Language: Unknown
    Publisher: Briefland
    Publication Date: 2012
    detail.hit.zdb_id: 2236753-6
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  • 9
    Online Resource
    Online Resource
    Antioxidant Activity of Cichorium intybus Extract in Concomitant Use with Melatonin Against Doxorubicin-induced Nephrotoxicity
    Briefland ; 2022
    In:  International Journal of Cancer Management Vol. 15, No. 12 ( 2022-12-11)
    Details
    In: International Journal of Cancer Management, Briefland, Vol. 15, No. 12 ( 2022-12-11)
    Abstract: Background: Doxorubicin is preferred to cure many malignancies. Its nephrotoxicity is a dangerous nature that is to operate with a warning. Antioxidants accompanied by anticancer could moderate the various side effects. Objectives: Cichorium intybus has nephron-protective effects. Melatonin stands as an antioxidant equivalent to others. The repairing effects of C. intybus-melatonin against the toxicity effects of doxorubicin on the kidneys were studied. Methods: Thirty 20 g to 25 g, balb/c mice were divided into 5 identical groups (n: 6). The research was grouped as control saline; DOX with the injection of doxorubicin; Chicory with the administration of the C. intybus complete extract following DOX; melatonin with the administration of the melatonin following DOX; both: With the administration of the chicory and melatonin following DOX. The histopathological study was set to determine degeneration, inflammation, and necrosis. Results: The mean of each histological phenomenon in the control group was significantly lower than in the DOX group. In the histopathology, we saw that all the treating groups, including C. intybus extract-received, melatonin-received, both of them received improved better than the doxorubicin-received group. The best improving mean was seen in the latter group. The DOX-induced nephrotoxicity could be improved by using the C. intybus extract and melatonin synchronously as therapeutic care. Conclusions: Synchronous administration of the chicory and melatonin has a healing potency against doxorubicin-induced nephrotoxicity.
    Type of Medium: Online Resource
    ISSN: 2538-4422 , 2538-497X
    URL: Journal
    URL: Article
    DOI: 10.5812/ijcm
    DOI: 10.5812/ijcm-127863
    Language: Unknown
    Publisher: Briefland
    Publication Date: 2022
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  • 10
    Online Resource
    Online Resource
    Synthesis and Biological Evaluation of Novel Anti-leukemia Proteolysis-Targeting Chimeras in Degradating Inosine Monophosphate Dehydrogenase
    Briefland ; 2022
    In:  Iranian Journal of Pharmaceutical Research Vol. 21, No. 1 ( 2022-09-10)
    Details
    In: Iranian Journal of Pharmaceutical Research, Briefland, Vol. 21, No. 1 ( 2022-09-10)
    Abstract: Background: Proteolysis-targeting chimera (PROTAC) is a bifunctional molecule comprising a ligand to recognize the targeted protein to be degraded. Objectives: To use the advantages of the PROTAC technique, we have synthesized novel compounds to degrade inosine monophosphate dehydrogenase (IMPDH) by the proteasome system. Methods: We describe the synthesis of new PROTACs based on a combination of mycophenolic acid (MPA) as the potent IMPDH inhibitor and pomalidomide as a ligand of E3 ubiquitin ligase via linkers formed from Cu(I)-catalyzed cycloaddition reaction. Results: All synthesized compounds were investigated against Jurkat cells as acute T-cell leukemia and were potent apoptosis inducers at 50 nM. Conclusion: The effect of compound 2 in 0.05 μM on IMPDH degradation can be almost prevented by competition with bortezomib as the proteasome inhibitor at 0.1 and 0.5 μM.
    Type of Medium: Online Resource
    ISSN: 1735-0328 , 1726-6890
    URL: Journal
    URL: Article
    DOI: 10.5812/ijpr
    DOI: 10.5812/ijpr-129251
    Language: Unknown
    Publisher: Briefland
    Publication Date: 2022
    detail.hit.zdb_id: 2578271-X
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