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  • 1
    Electronic Resource
    Electronic Resource
    EFFECTS OF ANTI-PARKINSONIAN DRUGS ON NEUROBEHAVIOURAL CHANGES INDUCED BY BILATERAL 6-HYDROXYDOPAMINE LESIONS IN RATS (1999)
    Melbourne, Australia : Blackwell Science Pty
    Clinical and experimental pharmacology and physiology 26 (1999), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. Effects of anti-Parkinsonian drugs on neurobehavioural changes induced by bilateral lesions of dopaminergic neurons were investigated in rats.2. Dopaminergic neurons in rats were lesioned bilaterally by injection of 6-hydroxydopamine (6-OHDA; 8 μg) into the medial forebrain bundle at the level of the posterolateral hypothalamus. As a result, a decrease in locomotor activity and marked catalepsy and prolongation of grasping time were observed.3. Levodopa, talipexole, bromocriptine and theophylline dose-dependently antagonized the decrease in locomotor activity induced by bilateral 6-OHDA lesions. These drugs also showed antagonistic effects on the appearance of catalepsy and prolongation of grasping time induced by bilateral 6-OHDA lesions. In contrast, trihexyphenidyl showed no antagonizing effect on the neurobehavioural changes induced by 6-OHDA lesions at any concentration tested.4. Combined treatment with levodopa and talipexole antagonized the neurobehavioural changes induced by bilateral 6-OHDA lesions, whereas no marked changes were observed when either drug was administered separately. The same findings were noted with the simultaneous use of either levodopa (2 mg/kg) and theophylline (2 mg/kg) or talipexole (0.005 mg/kg) and theophylline (2 mg/kg).5. These results indicate that this model may be useful for estimating the effects of drugs in the treatment of Parkinson's disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1440-1681.1999.03051.x
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  • 2
    Electronic Resource
    Electronic Resource
    Polymorphs of [(2S,3S)-α-Me-N,N'-bis(salicylidene)butane-2,3-diaminato]bis(pyridine)cobalt(III) tetrafluoroborate hydrate (1999)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 55 (1999), S. 1466-1470 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270199006812
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  • 3
    Electronic Resource
    Electronic Resource
    Synchrotron radiation X-ray powder diffractometer with a cylindrical imaging plate (2000)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 33 (2000), S. 1241-1245 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: A synchrotron radiation X-ray powder diffractometer for samples of very small amount has been developed to collect high-quality diffraction patterns under extreme conditions, i.e. at low temperature and/or high pressure. A new cylindrical imaging plate (CIP) is used as a detector, in addition to a conventional flat-type imaging plate (FIP). By using the CIP system, the diffraction data in a diffraction angle range −44 ≤ 2θ ≤ 122° are collected with a dynamic range of about 106. The alignment of the diffractometer, measurement and analysis are automatically operated by a workstation. A performance test shows that the CIP system has spatial resolution of about 0.07° with a dynamic range of 106. The diffraction pattern of a standard sample of Si measured by the CIP system has high quality; the refinement of the structure reaches Rw = 3.68% even in the case of a small amount of sample (about 2 µg) and a short exposure time (60 s). Examples of experiments at low temperatures under ambient and high pressures are also presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889800009286
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  • 4
    Electronic Resource
    Electronic Resource
    Structure of a tricyclo[4.3.0.03,7]nonane derivative (1986)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 42 (1986), S. 217-220 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270186096737
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  • 5
    Electronic Resource
    Electronic Resource
    The resolution function of a perfect-crystal three-axis X-ray spectrometer (1983)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 39 (1983), S. 38-46 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The resolution function of a three-axis, X-ray spectrometer is considered for the case when the monochromator and analyser crystals are ideally perfect. It is shown that, for X-ray sources which produce either an ill-collimated monochromatic beam (conventional source) or a well-collimated white beam (synchrotron radiation), the resolution problem may be simplified. This simplification allows the profile of an arbitrary section of the resolution function to be expressed as a one-dimensional integral of the product of three functions; one to represent the source characteristics and the other two to describe the Darwin profiles of the monochromator and analyser crystals. The formalism is extended to describe the measurement of the resolution function by a perfect crystal mounted on the sample table of the spectrometer. Comparison of the a priori calculations with measurements made on a spectrometer at a conventional source yields very good agreement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108767383000070
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  • 6
    Electronic Resource
    Electronic Resource
    The application of a position-sensitive detector to high-pressure X-ray diffraction using a diamond-anvil cell (1980)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 13 (1980), S. 284-289 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: A position-sensitive detector (PSD) for Mo Kα radiation has been successfully applied to detect very weak X-rays diffracted from an extremely small volume of specimen compressed in a diamond-anvil high-pressure cell. The PSD can cover a scattering-angle range of 22.6° with an angular resolution of 0.038: in a single measurement. Remarkably rapid recording of diffraction patterns with a high S/N ratio is performed with this method at pressures higher than 10 GPa. Some diffraction patterns of iodine near the insulator-metal transition around 16–18 GPa are shown to demonstrate the usefulness and power of this PSD system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889880012071
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