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  • 1
    Electronic Resource
    Electronic Resource
    Increased nuclear factor-erythroid 2 p45-related factor 2 activity protects SH-SY5Y cells against oxidative damage (2005)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 95 (2005), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The ability of cells to control the balance between the generation and quenching of reactive oxygen species is important in combating potentially damaging effects of oxidative stress. One mechanism that cells use to maintain redox homeostasis is the antioxidant response pathway. Antioxidant response elements (AREs) are cis-acting elements located in regulatory regions of antioxidant and phase II detoxification genes. Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) is a member of the Cap ‘n’ Collar family of transcription factors that binds to the ARE and regulates the transcription of specific ARE-containing genes such as NAD(P)H:quinone oxidoreductase 1, glutamylcysteine synthetase and heme oxygenase. Activation of Nrf2 results in release from its negative repressor, Kelch-like ECH-associated protein 1 (Keap1), and allows Nrf2 to translocate into the nucleus to induce gene expression. In this study, we demonstrate that increasing Nrf2 activity by various methods, including chemical induction, Nrf2 overexpression or Keap1 siRNA knockdown, protects cells against specific types of oxidative damage. Cells were protected against 6-hydroxydopamine- and 3-morpholinosydnonimine-mediated toxicity but not against 1-methyl-1-4-phenylpyridinium toxicity. As oxidative stress is a hallmark of several neurodegenerative disorders, including Parkinson's disease, pharmacological agents that selectively target the Keap1-Nrf2 pathway may provide a novel neuroprotective strategy for the treatment of these diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.2005.03377.x
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  • 2
    Electronic Resource
    Electronic Resource
    Haemophilia and advanced fibrin sealant technologies (1998)
    Oxford, UK : Blackwell Science Ltd
    Haemophilia 4 (1998), S. 0 
    Details
    ISSN: 1365-2516
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Fibrin sealant, which consists mainly of fibrinogen and thrombin, provides rapid haemostasis as well as tissue sealing and adhesion. Commercial, viralinactivated products are available in Europe, Canada, and Japan. Liquid fibrin sealant (LFS) has been used clinically in haemophiliacs to perform dental procedures, orthopedic surgeries, non-orthopaedic surgeries, and circumcisions. LFS use is expected to increase as commercial products will soon be available in the US. Recombinant sources and transgenic animal bioreactor systems will replace plasma-derived products and become the predominant sources for this product in the next decade. Other areas of innovation include the development of fibrin sealant bandages or dressings, expandable foams, and spray powders which will provide the haemophiliac the ability to rapidly attain control of traumatic haemorrhages prior to hospital treatment with a significant reduction in the use of IV clotting factors. Fibrin sealant products have the potential to provide life-saving control of haemorrhage, reduction in factor dependency, lower viral exposure risk, and medical care cost reduction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2516.1998.440449.x
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  • 3
    Electronic Resource
    Electronic Resource
    Epidemiological aspects of paediatric asthma (2004)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 34 (2004), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.2004.1961.x
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  • 4
    Electronic Resource
    Electronic Resource
    Maximum likelihood estimation of growth yields (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 24 (1982), S. 633-649 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: This work is concerned with statistical methods to estimate yield and maintenance parameters associated with microbial growth. For a given dilution rate, an experimenter typically measures substrate concentration, oxygen utilization rate, the rate of carbon dioxide evolution, and biomass concentration. These correlated response variables each contain information about the maintenance and yield parameters of interest. A maximum likelihood estimator which combines this correlated information for the yield and maintenance parameters is proposed, evaluated, and tested on literature data. Both point and interval estimators are considered.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260240309
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  • 5
    Electronic Resource
    Electronic Resource
    Application of data consistency tests and new parameter estimation methods to microbial growth on corn dust in batch culture (1981)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 23 (1981), S. 2333-2360 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The microorganism Candida utilis was grown on both filtered and unfiltered substrate obtained from enzymatic hydrolysis of starch in corn dust. For growth on filtered substrate, the average integrated biomass energetic yield value based on biomass-substrate data was η = 0.55 and for growth on unfiltered substrate an average yield value of η = 0.59 was obtained. Material and energy balances showed that the presence of unfiltered corn residue in the media had no significant effect on the yields. Statistical methods were developed and used to obtain best estimates of the growth parameters. Values of the biomass energetic yield corrected for maintenance (ηmax = 0.619) and the maintenance coefficient (me = 0.043) were obtained for growth on filtered substrate. Values of ηmax = 0.741 and me = 0.142 were obtained for the growth on unfiltered substrate. The consistency of data and parameter estimates was relatively good for filtered substrate; however, parameter estimates for unfiltered substrate were not consistent. Growth experiments without filtration of the products of starch hydrolysis resulted in protein-enriched products with about 39.73% protein.
    Additional Material: 14 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260231015
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  • 6
    Electronic Resource
    Electronic Resource
    Behandlung des Platinerzes (1847)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 40 (1847), S. 498-499 
    Details
    ISSN: 0021-8383
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prac.184704001115
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  • 7
    Electronic Resource
    Electronic Resource
    Die Glycoside von Adenium Boehmianum SchinzAuszug aus der Dissertation des leider allzufrüh verstorbenen J. C. Hess, die er noch kurz vor seinem plötzlichen Tod abschliessen, aber nicht mehr einreichen konnte.. Glykoside und Aglykone, 101. Mitteilung100. Mitteilung, J. v. Euw & T. Reichstein, Helv. 35, 1560 (1952).Die mit Buchstaben bezeichneten Fussnoten siehe bei den Formeln. (1952)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 35 (1952), S. 2202-2226 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Aus Adenium Boehmianum Schinz (ganze Pflanzen) wurden drei krist. herzaktive Glykoside isoliert. Der in grösster Menge (0,107%) erhaltene Stoff dürfte mit dem von Boehm aus derselben Pflanze erhaltenen Echujin identisch sein. Ein zweites Glykosid (0,0327% Ausbeute) war mit Somalin (V) identisch. Das dritte Glykosid wurde nur in kleiner Menge (0,0054%) erhalten und dürfte neu sein, wir nennen es Abobiosid. Nach Acetylierung der amorphen Anteile liess sich als vierter krist. Stoff (0,019%) Digitalinum-verum-hexacetat (XXIII) isolieren.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19520350705
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  • 8
    Electronic Resource
    Electronic Resource
    Identifizierung von Honghelosid G mit Somalin. Glykoside und Aglykone, 103. Mitt. (1953)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 36 (1953), S. 85-87 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Honghelosid G, ein Nebenglykosid aus den Wurzeln von A denium Honghel aus Nigeria, wurde mit der tiefschmelzenden Modifikation von Somalin identifiziert. Dieser Stoff konnte in geringer Menge auch in den Stengeln von Adenium Honghel aus Nigeria gefunden werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19530360113
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