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  • 1
    Electronic Resource
    Electronic Resource
    Double-blind placebo-controlled house dust mite control measures in adult patients with atopic dermatitis (2001)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 145 (2001), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Avoidance of allergens has been shown to be of benefit in patients with atopic asthma sensitized to indoor allergens. In atopic dermatitis, there is so far little information about the effect of house dust mite elimination strategies. Objectives We therefore performed a randomized controlled study of house dust mite control in patients with this disease. Methods Twenty adult patients with moderate to severe atopic dermatitis were included. Inclusion criteria were a positive RAST to house dust mite antigen (CAP class 〉 3) and a concentration of 〉 2 µg g−1 of the house dust mite antigen Der p1 in the patient's mattress dust. Patients were randomized to either the active treatment group (allergen-impermeable mattress encasing, acaricide spray containing tannic acid and benzylbenzoate) or a control group (allergen-permeable encasing, spray containing water and traces of ethanol). Severity of disease was estimated every 2 months by an established score (SCORAD), and eosinophil cationic protein (ECP) in the serum was determined by enzyme-linked immunosorbent assay. Furthermore, the use of topical steroids was quantified. Patients assessed daytime pruritus and pruritus-induced sleeplessness weekly on a visual analogue scale. The study lasted 1 year. Results At the end of the study, the active treatment group showed a statistically significant reduction in Der p1 exposure as compared with the control group. However, when comparing the change from the start to the end of the study, there was no statistically significant difference between active treatment and control groups as measured by the SCORAD score and by ECP levels in the serum. Some patients in the active treatment group reported less pruritus-induced sleeplessness, but there was no statistically significant difference between the two treatment groups. Conclusions For adult patients with atopic dermatitis it was shown that 1 year of house dust mite avoidance reduced the allergen exposure, but an improvement of overall disease activity was not demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2001.04283.x
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  • 2
    Electronic Resource
    Electronic Resource
    Atopic dermatitis and house dust mite control measures: reply from author (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.480911.x
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  • 3
    Electronic Resource
    Electronic Resource
    Comparison of different activity parameters in atopic dermatitis: correlation with clinical scores (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary Background Several laboratory markers have been described to correlate positively with disease activity of atopic dermatitis (AD). These include soluble adhesion molecules and eosinophil granular proteins. Although the correlation of these parameters with the severity and extent of skin involvement has been repeatedly studied in the past, no systematic investigation has been performed over a lengthy period of time. In addition, no subjective disease parameters recorded by the patient have been included in studies dealing with disease activity. Objectives To assess the validity of different objective and subjective parameters [soluble E-selectin (sE-selectin), soluble vascular cell adhesion molecule-1 (sVCAM-1), eosinophil cationic protein (ECP), urinary nitrate excretion (reflecting endogenous nitric oxide formation) and the patients' impressions of pruritus, sleeplessness and skin status] as markers of AD disease activity. Methods Twenty patients were examined for 1 year and their skin status was evaluated by an established score (SCORAD). sE-selectin, sVCAM-1 and ECP were analysed by commercial test kits. Urinary nitrate concentration was measured by gas chromatography-mass spectrometry. The subjective parameters, pruritus, sleeplessness and impression of skin status, were recorded by the patients on a visual analogue scale. Results In this long-term trial, only sE-selectin and the subjective parameters showed a statistically significant correlation with the SCORAD score. Conclusions Our data indicate that basic clinical scoring remains a most effective and relevant method of recording skin disease activity in AD.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.04938.x
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  • 4
    Electronic Resource
    Electronic Resource
    Der infizierte arterielle Stent (1998)
    Springer
    Der Chirurg 69 (1998), S. 872-876 
    Details
    ISSN: 1433-0385
    Keywords: Key words: PTA ; Arterial stenting ; Bacterial arteritis ; Septic embolization ; Staphylococcus aureus. ; Schlüsselwörter: Percutane Angioplastie ; arterielle Stentimplantation ; bakterielle Arteriitis ; septische Embolisierung ; Staphylococcus aureus.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Gefäßinfektionen nach percutanen endovasculären Maßnahmen sind selten. Wir berichten von einer bakteriellen Arteriitis nach PTA und Stentimplantation in eine Iliacalarterie mit konsekutiver septischer Embolisierung, ipsilateralem Kniegelenkempyem und Ausbildung eines infizierten Aneurysma spuriums. Als Ursache muß eine Kontamination des Stents mit Staphylococcus aureus angenommen werden. Die Behandlung bestand in der Resektion des entzündeten Gefäßabschnittes mit Stententfernung und autologer Rekonstruktion.
    Notes: Summary. Vascular infections after percutaneous endovascular procedures are rare. We report a case of bacterial arteritis following PTA and stent implantation into an iliac artery. It was complicated by septic embolization, ipsilateral empyema of the knee joint and formation of an infected false aneurysm. Contamination of the stent with Staphylococcus aureus is likely to be the cause. The treatment included resection of the infected arterial segment, removal of the stent, and autologous reconstruction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001040050504
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  • 5
    Electronic Resource
    Electronic Resource
    Reasons for the decomposition of the fungicide thiram during preparation of fruit and vegetable samples and consequences for residue analysis (2000)
    Springer
    Fresenius' journal of analytical chemistry 366 (2000), S. 851-856 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The concentration of thiram in aqueous solution decreases by 50–75% within 20 min in the presence of cut pieces of apple, cucumber or celeriac with a section surface area of 160 cm2 each. The decomposition rate is predominantly influenced by the section surface area of the cut fruit and vegetable samples. Denaturing reaction conditions (exchange of the solvent water by methanol; boiling of sample material) will significantly slow down the decomposition rate. It was concluded that the thiram decomposition had been caused by enzymes on the section surface of the fruit and vegetable samples. For a specific determination of thiram, a simple rinsing of the intact fruit and vegetable material was appropriate as extraction method. For the screening of thiram residues, the often used Keppel method, which determines CS2 from thiram or dithiocarbamates seems to be applicable even if samples had been coarsely cut, since decomposition of the CS2-forming intermediates is slower than the breakdown of thiram itself. Therefore, specific determination of thiram is necessary only, if maximum residue limits for dithiocarbamates are not adhered to.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160051584
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