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  • Blackwell Science Ltd  (1)
  • New York :Columbia University Press,  (1)
  • The American Society for Biochemistry and Molecular Biology (ASBMB)  (1)
  • 1
    Online Resource
    Online Resource
    Rheology and Deformation of the Lithosphere at Continental Margins. (2004)
    New York :Columbia University Press,
    Details
    Keywords: Earth - Crust. ; Electronic books.
    Description / Table of Contents: Traditionally, investigations of the rheology and deformation of the lithosphere (the rigid or mechanically strong outer layer of the Earth, which contains the crust and the uppermost part of the mantle) have taken place at one scale in the laboratory.
    Type of Medium: Online Resource
    Pages: 1 online resource (367 pages)
    Edition: 1st ed.
    ISBN: 9780231501897
    Series Statement: MARGINS Theoretical and Experimental Earth Science Series
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=909214
    DDC: 551.8
    Language: English
    Note: Intro -- Table of Contents -- List of Contributors -- Preface -- 1. Consequences of Asthenospheric Variability in Continental Rifting, by W. Roger Buck -- 2. Velocity Fields, Faulting, and Strength on the Continents, by James Jackson -- 3. Mechanics of Low-Angle Normal Faults, by Gary J. Axen -- 4. Depth-Dependent Lithospheric Stretching at Rifted Continental Margins, by Mark Davis and Nick Kusznir -- 5. Limits of the Seismogenic Zone, by Larry J. Ruff -- 6. Controls on Subduction Thrust Earthquakes: Downdip Changes in Composition and State, by R. D. Hyndman -- 7. Thermo-Mechanical Models of Convergent Orogenesis: Thermal and Rheologic Dependence of Crustal Deformation, by Sean D. Willett and Daniel C. Pope -- 8. Structure of Large-Displacement, Strike-Slip Fault Zones in the Brittle Continental Crust, by F. M. Chester, J. S. Chester, D. L. Kirschner, S. E. Schulz, and J. P. Evans -- 9. The Strength of the San Andreas Fault: A Discussion, by Christopher H. Scholz and Thomas C. Hanks -- 9. The Strength of the San Andreas Fault: A Discussion, by Christopher H. Scholz and Thomas C. Hanks -- 11. Relations Among Porosity, Permeability, and Deformation in Rocks at High Temperatures, by Brian Evans, Yves Bernable, and Greg Hirth -- Index.
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    GEOMAR EBL
  • 2
    Electronic Resource
    Electronic Resource
    Preparing young adults with disability for employment (2004)
    Oxford, UK : Blackwell Science Ltd
    Health & social care in the community 12 (2004), S. 0 
    Details
    ISSN: 1365-2524
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Young people with disabilities are often excluded from the labour market. The present paper describes an evaluation of an innovative 2-year pilot initiative called Vocational Opportunities in Training for Employment (VOTE) implemented in Northern Ireland to provide employment training and support for vulnerable young adults with a wide range of disabilities. The principal aims of the study were to assess the impact of the new service in the extent to which: (1) it had created and developed training and employment opportunities for young people; and (2) promoted inclusive working partnerships. Documentary analysis was used as a basis for describing and assessing the project objectives in combination with face- to-face interviews with a small number of key stakeholders. A total of 122 young people participated in the initiative in the pilot period, during which time 160 qualifications were obtained. Key stakeholders expressed positive views about the initiative, and in particular, its therapeutic benefits and the extent of interagency working and shared learning. The VOTE initiative achieved considerable success in enabling a significant proportion of young adults to engage in society by developing social and employment skills, and by improving their employment opportunities and prospects. Factors critical to the continued success of this and similar initiatives include: the close involvement of parents; addressing the concerns of local employers; the sympathetic treatment of workplace issues; and effective partnership working.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.0966-0410.2004.00472.x
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    Paper (German National Licenses)
    Fulltext
  • 3
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    Protein arginine methyltransferase 1 modulates innate immune responses through regulation of peroxisome proliferator-activated receptor {gamma}-dependent macrophage differentiation [Molecular Bases of Disease] (2017)
    The American Society for Biochemistry and Molecular Biology (ASBMB)
    Details
    Publication Date: 2017-04-29
    Description: Arginine methylation is a common posttranslational modification that has been shown to regulate both gene expression and extranuclear signaling events. We recently reported defects in protein arginine methyltransferase 1 (PRMT1) activity and arginine methylation in the livers of cirrhosis patients with a history of recurrent infections. To examine the role of PRMT1 in innate immune responses in vivo, we created a cell type-specific knock-out mouse model. We showed that myeloid-specific PRMT1 knock-out mice demonstrate higher proinflammatory cytokine production and a lower survival rate after cecal ligation and puncture. We found that this defect is because of defective peroxisome proliferator-activated receptor γ (PPARγ)-dependent M2 macrophage differentiation. PPARγ is one of the key transcription factors regulating macrophage polarization toward a more anti-inflammatory and pro-resolving phenotype. We found that PRMT1 knock-out macrophages failed to up-regulate PPARγ expression in response to IL4 treatment resulting in 4-fold lower PPARγ expression in knock-out cells than in wild-type cells. Detailed study of the mechanism revealed that PRMT1 regulates PPARγ gene expression through histone H4R3me2a methylation at the PPARγ promoter. Supplementing with PPARγ agonists rosiglitazone and GW1929 was sufficient to restore M2 differentiation in vivo and in vitro and abrogated the difference in survival between wild-type and PRMT1 knock-out mice. Taken together these data suggest that PRMT1-dependent regulation of macrophage PPARγ expression contributes to the infection susceptibility in PRMT1 knock-out mice.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
    Published by The American Society for Biochemistry and Molecular Biology (ASBMB)
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    PAPER CURRENT
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