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Immunohistochemical study of autoimmune pancreatitis using anti-IgG4 antibody and patients' sera (2005)

Aoki, S ; Nakazawa, T ; Ohara, H ; [et al.]

Oxford, UK : Blackwell Science Ltd

Histopathology 47 (2005), S. 0

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ISSN: 1365-2559

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Aims : Autoimmune pancreatitis (AIP), characterized by raised serum IgG4 levels, is frequently complicated by disorders of extrapancreatic organs. The aim of the present study was to examine immunohistochemically which extrapancreatic organs are affected, and whether an autoantibody to such organs is present in the serum of AIP patients.Methods : Various tissues/organs obtained from AIP patients were studied immunohistochemically with an anti-IgG4 antibody. To examine the presence of an autoantibody in the serum of AIP patients, sera were incubated with various normal organs/tissues extracted for other diseases, followed by detection with an anti-IgG4 antibody. Sera were also examined before and after glucocorticoid therapy.Results : Marked infiltration of IgG4+ plasma cells was observed in the pancreas, liver, bile duct and salivary gland of many of the AIP patients examined. The normal epithelia of the pancreatic ducts, bile ducts, gallbladder and salivary gland ducts reacting with the patients' sera were detectable by the anti-IgG4 antibody. Following glucocorticoid therapy the IgG4 antibody from the patients' sera showed decreased reactivity with these tissues.Conclusions : AIP may also affect extrapancreatic organs, the serum of AIP patients may contain an IgG4 autoantibody to various organs and glucocorticoid therapy may improve such disorders.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2559.2005.02204.x

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Stability problem of Kirkwood Gaps (1978)

AOKI, S.

[s.l.] : Nature Publishing Group

Nature 275 (1978), S. 568-568

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ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] KIANG noticed1 the importance of the Kirkwood Gaps (particularly the Hecuba Gap) in contrast to Hilda Group in the asteroidal distribution problem, and presented a solution to this problem using a stability criterion inherited in Hill's equation which, he assumed, clarifies the difference between ...