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  • 1
    Online Resource
    Online Resource
    Ganzheitliche Digitalisierung Von Prozessen : Perspektivenwechsel - Design Thinking - Wertegeleitete Interaktion (2018)
    Wiesbaden : Springer Fachmedien Wiesbaden GmbH
    Details Availability
    Keywords: Electronic books
    Description / Table of Contents: Intro -- Vorwort -- Inhaltsverzeichnis -- Über die Autoren -- 1 Motivation -- 1.1 Geschäftsprozesse und Geschäftsprozessmanagement -- 1.2 Blick auf die Welt, Strukturierung und Modellbildung -- 1.3 Bestandteile einer Prozessbeschreibung -- 1.4 Rahmenbedingungen für Prozessmodelle und Prozessinstanzen -- 1.5 Prozesskennzahlen -- 1.6 Unterstützungskonzepte -- 1.7 Digitalisierung -- 1.8 Prozess zum Erstellen von Prozessen -- 1.9 Organisatorische und technische Implementierung -- 1.10 Erfolgsmessung mit Kennzahlen -- 1.11 Kontinuierliche Verbesserung -- 1.12 Unternehmensführung und Geschäftsprozessmanagement -- Literatur -- 2 Modelle -- 2.1 Modell und Wirklichkeit -- 2.2 Eigenschaften von Modellen -- 2.3 Modelle der Sozialwissenschaften -- 2.3.1 Taylorismus und Fordismus -- 2.3.2 Kommunikatives Handeln nach Habermas -- 2.3.3 Soziale Systeme nach Luhmann -- 2.3.4 Organisationen -- 2.4 Modelle der Betriebswirtschaft -- 2.4.1 Geschäftsmodell -- 2.4.2 Balanced Scorecard -- 2.4.3 Total Quality Management und EFQM -- 2.4.4 EN ISO 9001 -- 2.4.5 Value Networks -- 2.5 Modelle der Wirtschaftsinformatik -- 2.5.1 Unternehmensarchitekturen -- 2.5.1.1 Zachman-Framework -- 2.5.1.2 The Open Group Architecture Framework (TOGAF) -- 2.5.1.3 Architecture-Animate (ArchiMate) -- 2.5.1.4 Architektur Integrierter Informationssysteme (ARIS) -- 2.5.2 Framework für IT-Service-Management: ITIL® -- 2.6 Modelle der Informatik -- 2.6.1 Information -- 2.6.2 Entity-Relationship-Modell -- 2.6.3 Fluss- oder Ablaufdiagramme -- 2.6.4 Petrinetze -- 2.6.5 Calculus of Communicating Systems -- 2.6.6 π-Kalkül -- 2.6.7 Communicating Sequential Processes -- 2.6.8 Abstract State Machines -- 2.6.9 Objektorientierte Modelle -- 2.6.10 Agenten-/Aktoren-orientierte Modelle -- 2.7 Fazit: Modelle für Geschäftsprozesse -- Literatur -- 3 Modellierungssprachen -- 3.1 Überblick -- 3.2 Flowcharts.
    Type of Medium: Online Resource
    Pages: 1 online resource (262 pages)
    ISBN: 9783658226480
    URL: https://ebookcentral.proquest.com/lib/kxp/detail.action?docID=6422823
    Language: German
    Note: Description based on publisher supplied metadata and other sources
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  • 2
    Online Resource
    Online Resource
    Untersuchungen schneller gravitroper Primärreaktionen von Pilzen und Höheren Pflanzen bei verschiedenen Beschleunigungsreizen : Schlussbericht ; Berichtszeitraum: 01. April 2004 - 30. Juni 2007 (2007)
    Marburg : Univ., FB Biologie
    Details Availability
    Keywords: Forschungsbericht
    Type of Medium: Online Resource
    Pages: Online-Ressource (6 S., 53,3 KB)
    URL: https://edocs.tib.eu/files/e01fb08/567177564.pdf
    URL: https://doi.org/10.2314/GBV:567177564
    URL: https://edocs.tib.eu/files/e01fb08/567177564l.pdf
    DOI: 10.2314/GBV:567177564
    Language: German
    Note: Förderkennzeichen BMBF 50WB0425. - Engl. Titel: Investigations on fast gravitropic primary responses of fungi and higher plants at different accelerations , Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden , Auch als gedr. Ausg. vorhanden , Systemvoraussetzungen: Acrobat reader.
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  • 3
    Electronic Resource
    Electronic Resource
    Four different types of protease-activated receptors are widely expressed in the brain and are up-regulated in hippocampus by severe ischemia (2001)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 14 (2001), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A variety of extracellular serine proteases are expressed in the central nervous system or might permeate the blood–brain barrier under pathological conditions. However, their intracerebral targets and physiological functions are largely unknown. Here, we show that four distinct subtypes of protease-activated receptors (PARs) are abundantly expressed in the adult rat brain and in organotypic hippocampal slice cultures. PAR-1 expression was significant in the hippocampus, cortex and amygdala. Highest densities of PAR-2 and PAR-3 were observed in hippocampus, cortex, amygdala, thalamus, hypothalamus and striatum. Apart from the striatum, a similar localization was found for PAR-4. Within the hippocampal formation, each PAR subtype was predominantly localized in the pyramidal cell layers. Additionally, we identified PAR-2 in mossy fibers between dentate gyrus and CA3, PAR-3 in the subiculum and PAR-4 in CA3 and in mossy fibres as well as in the stratum lacunosum moleculare. After exposing hippocampal slice cultures to a severe experimental ischemia (oxygen–glucose deprivation), the expression of PARs 1–3 was up-regulated with subtype-specific kinetics. The localization of PARs in brain regions particularly vulnerable to ischemic insults as well as distinct alterations in the expression pattern after experimental ischemia support the notion of an important role of extracellular serine proteases and PARs in cerebral ischemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.0953-816x.2001.01676.x
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  • 4
    Electronic Resource
    Electronic Resource
    Functional heterogeneity of the rat medial prefrontal cortex: effects of discrete subarea-specific lesions on drug-induced conditioned place preference and behavioural sensitization (1999)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 11 (1999), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: While the principal components of the brain reward system, the nucleus accumbens septi and the ventral tegmental area have received much attention, their efferent and afferent structures have not been investigated to the same degree. One major input to this system originates from the medial prefrontal cortex (mPFC) which is not a homogenous structure but can be divided into different subareas that can be distinguished on anatomical and possibly functional grounds. We examined the effects of discrete bilateral quinolinic acid lesions (45 nmol/0.5 μL) of each of the mPFC subareas, the infralimbic (il), prelimbic (pl) and the anterior cingulate (cg) mPFC, on the conditioned place preference (CPP) and psychomotor activation induced by several drugs. Lesions of the il mPFC blocked CPP induced by morphine (10 mg/kg) and CGP37849 [dl-(E)-2-amino-4-methyl-5-phosphono-3-pentic acid, a competitive N-methyl-d-aspartate receptor antagonist; 10 mg/kg]. Lesions of the pl mPFC blocked CPP induced by cocaine (15 mg/kg) and CGP37849, and lesions of the cg mPFC only blocked CGP37849-induced CPP. Lesions of the whole mPFC blocked morphine-, cocaine- and CGP37849-induced CPP. None of the lesions affected dl-amphetamine (4 mg/kg)-induced CPP. During the conditioning period, none of the lesions affected amphetamine-induced psychomotor activation and sensitization, whereas both phenomena were attenuated by pl and whole mPFC lesions in the case of cocaine, and by il and whole mPFC lesions in the case of morphine. These results show that the different mPFC subregions have distinct functional roles in the generation of behavioural effects produced by different classes of drugs. This heterogeneity should be taken into account in future studies addressing the role of the mPFC in drug reward and sensitization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.1999.00834.x
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  • 5
    Electronic Resource
    Electronic Resource
    State-dependent blockade of haloperidol-induced sensitization of catalepsy by MK-801 (1999)
    Oxford, UK : Blackwell Science Ltd
    European journal of neuroscience 11 (1999), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: NMDA receptor antagonists have been shown to block several forms of neural and behavioural plasticity. The prototypical and most widely-used noncompetitive NMDA receptor antagonist is dizocilpine (MK-801). Here we have examined the effect of MK-801 on the context-dependent augmentation (‘sensitization’) of catalepsy in rats which develops with repeated administration of haloperidol. It was found that over a 7-day treatment period animals receiving haloperidol (0.25 or 0.5 mg/kg) plus MK-801 (0.16 mg/kg) showed a context-dependent day-to-day increase in catalepsy similar to animals that received haloperidol alone. However, when all animals were treated with haloperidol alone on day 8 of the experiment, animals that had received haloperidol plus MK-801 before displayed a much smaller cataleptic response, similar to that observed in the haloperidol group on the first treatment day, i.e. the previously-established enhancement of catalepsy was no longer expressed. These results may be explained in terms of state-dependency effects induced by MK-801. Implications of these findings for the clinical use of NMDA receptor antagonists in the treatment of Parkinson's disease are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.1999.00794.x
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  • 6
    Electronic Resource
    Electronic Resource
    Über den einfluß von fängern auf die hochfeldpolymerisation von α-methylstyrol (1974)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 175 (1974), S. 2687-2703 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Cation scavengers (N(C2H5)3, H2O, cyclopropane) inhibit the polymerization of liquid α-methylstyrene initiated by field emission (FE). Electron scavengers also inhibit the polymerization with efficiencies declining in the series SF6〉N2O〉CO2〉O2. It is assumed that electrons emitted by the high field electrode ionize monomer molecules. Radical cations formed thereby initiate the cationic polymerization. Thus cation scavengers inhibit the growth of kinetic chains, whereas electron scavengers inhibit the initiation reaction.The polymerization initiated by field ionization (FI) is not affected by electron scavengers. However, cation scavengers inhibit this polymerization.Based on the dependence of the specific polymer yield on the N(C2H5)3-concentration it was estimated that in the case of FE only 1 to 10% of the emitted electrons initiate polymerization. In the case of FI up to 100% of the ions generated at the high field electrode start kinetic chains.During all experiments oligomer (degree of polymerization 3 to 4) was formed in a chain reaction. The specific oligomer yield increased with increasing SF6-concentration significantly when the reaction was initiated by FE.
    Notes: Die durch Feldemission (FE) in flüssigem α-Methylstyrol ausgelöste Polymerisation wird durch Kationenfänger (N(C2H5)3, H2O, Cyclopropan) inhibiert. Die Elektronenfänger SF6, N2O, CO2 und O2 inhibieren ebenfalls, wobei die Inhibitorwirksamkeit in der genannten Reihenfolge abnimmt. Dieses Verhalten wird darauf zurückgeführt, daß von der Hochfeldelektrode emittierte Elektronen Monomermolekeln ionisieren; dabei gebildete Radikalkationen starten die kationische Polymerisation. Durch Kationenfänger wird daher die Wachstumsreaktion inhibiert, während Elektronenfänger die Startreaktion inhibieren.Bei der durch Feldionisation (FI) gestarteten Polymerisation sind Elektronenfänger wirkungslos; Kationenfänger inhibieren dagegen.Aufgrund der Abhängigkeit der spezifischen Polymerausbeute von der N(C2H5)3-Konzentration wurde abgeschätzt, daß im Falle der FE nur 1 bis 10% der emittierten Elektronen polymerisationsauslösend wirken. Im Falle der FI starten bis zu 100% der an der Hochfeldelektrode erzeugten Ladungsträger kinetische Ketten.Bei allen Versuchen wurde Oligomeres (Polymerisationsgrad 3 bis 4) durch eine Kettenreaktion gebildet. Die spezifische Oligomerausbeute nahm bei der FE-initiierten Polymerisation mit steigender SF6-Konzentration bemerkenswert zu.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1974.021750914
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  • 7
    Electronic Resource
    Electronic Resource
    Milde oxidative Abspaltung der p-Methoxybenzylether-Schutzgruppe durch homogene Elektronenübertragung (1978)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 90 (1978), S. 717-717 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19780900911
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  • 8
    Electronic Resource
    Electronic Resource
    Das „Equivalent Orbital“ (EO)-Verfahren zur Interpretation von Photoelektronen(PE)-Spektren: Neopentan (1972)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 84 (1972), S. 168-170 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19720840416
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  • 9
    Electronic Resource
    Electronic Resource
    Electrical conductivity changes of polymers with conjugated double bonds induced by exposure to vapors and gases (1993)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 208 (1993), S. 151-165 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Die Einwirkung von oxidierenden oder reduzierenden Gasen oder Dämpfen auf Polyacetylen, Polypyrrol, Poly(phenylacetylen) und Poly-p-phenylen führt zu Änderungen der elektrischen Leitfähigkeit. Dieser Effekt wird an Hand eines Drei-Stufen-Modells erklärt. Als erste Stufe wird die Adsorption an der Polymeroberfläche angenommen. Die zweite Stufe besteht in der Diffusion der Adsorbatmoleküle in das Innere des Polymeren, während die dritte Stufe durch eine irreversible Reaktion zwischen Adsorbatmolekülen und Polymerem gegeben ist. Diese drei Reaktionstufen sind manchmal zeitlich voneinander abgegrenzt. Während der Adsorptionsstufe ist die elektrische Leitfähigkeitsänderung reversibel, wenn durch Abpumpen das Gas oder der Dampf wieder entfernt werden.
    Notes: Exposure of polyacetylene, polypyrrole, poly(phenylacetylene), and poly-p-phenylene to oxidizing or reducing gases and vapors leads to changes of their electrical conductivity which can be explained by a three step model involving as a first step adsorption at the surface, as a second step diffusion into the bulk of the material and as a third step irreversible chemical changes due to reaction between the dopant and the polymer chain. These three regimes are sometimes well separated in time. During the adsorption regime, the conductivity change is reversible with respect to removal of the vapor atmosphere by evacuation.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1993.052080114
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  • 10
    Electronic Resource
    Electronic Resource
    Die Racemisierung spirocyclischer Pentaarylderivate von Elementen der V. Hauptgruppe, I. 1H-NMR-Untersuchungen mit sterisch überbesetzten asymmetrischen Phosphoranen, Arsoranen und Stiboranen (1979)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 112 (1979), S. 281-291 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The Racemization of Spirocyclic Pentaaryl Derivatives of Group 5 A Elements. I H NMR Investigations with Overcrowded Asymmetric Phosphoranes, Arsoranes, and StiboranesThe two different methyl positions of bis-2,2′-biarylylenephosphorane 7, the corresponding arsoranes 8a, b, and the analogous stiborane 9 are reversibly equilibrated at elevated temperatures with free enthalpies of activation of 18.2 (76.0), 17.2 (72.2), ≈ 22.5 (94.2), and 15.4 (64.6) kcal(kJ)/mol. Starting with the trigonal bipyramidal ground state conformations C and ∪ (fig. 2) these ligand exchange phenomena can be interpreted in the framework of the pseudorotation process on the basis of trigonal bipyramidal transition states of type A with diequatorial biarylylene groups.
    Notes: Die beiden unterschiedlichen Methyl-Positionen des Bis-2,2′-biarylylenphosphorans 7, der entsprechenden Arsorane 8a, b und des analogen Stiborans 9 werden bei erhöhten Temperaturen mit freien Aktivierungsenthalpien von 18.2 (76.0), 17.2 (72.2). ≈ 22.5 (94.2) und 15.4 (64.6) kcal(kJ)/mol reversibel äquilibriert. Ausgehend von den trigonal-bipyramidalen Grundzustandskonformationen C und ∪ (Abb. 2) lassen sich diese Ligandenaustauschphänomene im Rahmen des Pseudorotationsprozesses auf der Basis trigonal-bipyramidaler Übergangszustände des Typs A (Abb. 2) mit diäquatorialen Biarylylen-Gruppen interpretieren.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19791120125
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