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  • 1
    Electronic Resource
    Electronic Resource
    Immunohistochemical study of autoimmune pancreatitis using anti-IgG4 antibody and patients' sera (2005)
    Oxford, UK : Blackwell Science Ltd
    Histopathology 47 (2005), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aims : Autoimmune pancreatitis (AIP), characterized by raised serum IgG4 levels, is frequently complicated by disorders of extrapancreatic organs. The aim of the present study was to examine immunohistochemically which extrapancreatic organs are affected, and whether an autoantibody to such organs is present in the serum of AIP patients.Methods : Various tissues/organs obtained from AIP patients were studied immunohistochemically with an anti-IgG4 antibody. To examine the presence of an autoantibody in the serum of AIP patients, sera were incubated with various normal organs/tissues extracted for other diseases, followed by detection with an anti-IgG4 antibody. Sera were also examined before and after glucocorticoid therapy.Results : Marked infiltration of IgG4+ plasma cells was observed in the pancreas, liver, bile duct and salivary gland of many of the AIP patients examined. The normal epithelia of the pancreatic ducts, bile ducts, gallbladder and salivary gland ducts reacting with the patients' sera were detectable by the anti-IgG4 antibody. Following glucocorticoid therapy the IgG4 antibody from the patients' sera showed decreased reactivity with these tissues.Conclusions : AIP may also affect extrapancreatic organs, the serum of AIP patients may contain an IgG4 autoantibody to various organs and glucocorticoid therapy may improve such disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.2005.02204.x
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    Paper (German National Licenses)
    Fulltext
  • 2
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    Environmental Study on the Deep-sea Mining of Manganese Nodules in the Northeastern Tropical Pacific - Modeling the sediment-laden negative buoyant flow (1999)
    ISOPE
    In:  In: Proceedings of the Third (1999) Ocean Mining Symposium Goa, India, November 8-10, 1999. ISOPE, Golden, Colo., pp. 163-168.
    Details
    Publication Date: 2016-10-28
    Description: A 3-D hydrodynamic model for sediment transport has been developed to assess the environmental impact of benthic disturbance during the deep-sea mining activity. The model was applied to the Japan Deep-Sea Impact Experiment (JET) and a series of numerical simulations were carried out in order to reproduce the observed sedimentation profile of resuspended particles. Although the general tendency was reproduced in every simulation run, the observed resedimentation maxima at the northern and the southern ends of disturber towing zone could not be accounted for after all. The' discrepancy seemed to be partly because the model did not take into account the effect of sediment-laden negative buoyant flow which must contribute to the transport of resuspended sediment. Thus the model was modified to include the density effect associated with the resuspension of sediment, and then applied again to JET site to examine how the reproducibility of the resedimentation profile was improved. From the comparison of model results, it turned out that the sediment-laden negative buoyant effect plays an important role in improving the predictive capability of the model, but does not cause the model to reproduce the double-peak phenomenon of resedimentation at the ends of towing zone. This suggests that the complete reproduction of the double-peak phenomenon requires another simulation that takes into account the sediment-laden negative buoyant effect as well as an artificial sediment source involved in recovery operations of the seabed disturber.
    Type: Book chapter , NonPeerReviewed
    Format: text
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    OceanRep: Book chapter
  • 3
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    Genomic Analyses of Sperm Fate Regulator Targets Reveal a Common Set of Oogenic mRNAs in Caenorhabditis elegans [Developmental and Behavioral Genetics] (2016)
    Genetics Society of America (GSA)
    In: Genetics
    Details
    Publication Date: 2016-01-06
    Description: Germ cell specification as sperm or oocyte is an ancient cell fate decision, but its molecular regulation is poorly understood. In Caenorhabditis elegans , the FOG-1 and FOG-3 proteins behave genetically as terminal regulators of sperm fate specification. Both are homologous to well-established RNA regulators, suggesting that FOG-1 and FOG-3 specify the sperm fate post-transcriptionally. We predicted that FOG-1 and FOG-3 , as terminal regulators of the sperm fate, might regulate a battery of gamete-specific differentiation genes. Here we test that prediction by exploring on a genomic scale the messenger RNAs (mRNAs) associated with FOG-1 and FOG-3 . Immunoprecipitation of the proteins and their associated mRNAs from spermatogenic germlines identifies 81 FOG-1 and 722 FOG-3 putative targets. Importantly, almost all FOG-1 targets are also FOG-3 targets, and these common targets are strongly biased for oogenic mRNAs. The discovery of common target mRNAs suggested that FOG-1 and FOG-3 work together. Consistent with that idea, we find that FOG-1 and FOG-3 proteins co-immunoprecipitate from both intact nematodes and mammalian tissue culture cells and that they colocalize in germ cells. Taking our results together, we propose a model in which FOG-1 and FOG-3 work in a complex to repress oogenic transcripts and thereby promote the sperm fate.
    Print ISSN: 0016-6731
    Topics: Biology
    Published by Genetics Society of America (GSA)
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