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  • Institute of Physics Publishing (IOP)  (9)
  • International Union of Crystallography (IUCr)  (7)
  • Blackwell Science Ltd  (6)
  • Cold Spring Harbor Laboratory Press  (4)
  • 1
    Electronic Resource
    Electronic Resource
    Macrophage Heterogeneity, Antigen Presentation, and Membrane Fluidity: Implications in Visceral Leishmaniasis (2001)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 53 (2001), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Morphological and functional heterogeneity of the splenic macrophage (Mφ) population was studied in Leishmania donovani (LD) infected BALB/c mice. On a discontinuous percoll gradient two distinct Mφ populations were separated. They differed significantly in size as evident from Scanning Electron Microscopy (SEM). Morphologically, the bigger Mφ (LM) showed surface projections, whereas the smaller Mφ (SM) was round. As regards the antigen-presenting abilities, the LM of infected animals showed defective antigen-presenting abilities at a later stage of the disease, i.e. 6 months post infection (6I-LM) but not earlier, whereas the SM population remained functionally intact throughout the course of the infection. Further, the 6I-LM showed a much enhanced Ad status as compared to their controls. Interestingly, both the 6I-LM and the control set showed a comparable level of binding of a known Ad restricted peptide. Despite the presence of sufficient Ad molecules and the ability to bind the appropriate peptide, 6I-LM were unable to stimulate peptide specific T-cell hybridoma. Further, the 6I-LM showed an increase in membrane fluidity and distorted morphology with membrane fissure and blebs as evident from SEM. It is possible that an increase in the membrane fluidity may lead to the defective antigen-presenting ability of 6I-LM. Thus, the LD infection functionally keep the 6I-LM out of antigen presentation and this may contribute to the defective cell mediated immune response in leishmaniasis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.2001.00856.x
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  • 2
    Electronic Resource
    Electronic Resource
    Infection of Human Mononuclear Phagocytes and Macrophage-Like THP1 Cells with Leishmania donovani Results in Modulation of Expression of a Subset of Chemokines and a Chemokine Receptor (2003)
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 57 (2003), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The expression of chemokines and chemokine receptors was studied in Leishmania donovani (LD)-infected human mononuclear phagocytes and the human monocytic cell line THP1. Our studies showed that LD infection caused the upregulation of three β chemokines (macrophage inflammatory protein-1 alpha (MIP-1α), MIP-1β and RANTES (regulated on activation normal T cell expressed and secreted)), one α chemokine (interleukin-8 (IL-8)) and the CC chemokine receptor 5 (CCR5) but not CCR1, as evident from reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. The CCR5 upregulation in human mononuclear phagocytes and THP1 cells was also evident by confocal microscopy. The possible association of such upregulation in relation to Leishmania and human immunodeficiency virus (HIV) coinfection was discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-3083.2003.01227.x
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  • 3
    Electronic Resource
    Electronic Resource
    Malignant melanoma in the 21st century (2000)
    Oxford, UK : Blackwell Science Ltd
    International journal of dermatology 39 (2000), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-4362.2000.00875.x
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  • 4
    Electronic Resource
    Electronic Resource
    Tetracycline and other tetracycline-derivative staining of the teeth and oral cavity (2004)
    Oxford, UK : Blackwell Science Ltd
    International journal of dermatology 43 (2004), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Tetracyclines (TCN) were introduced in 1948 as broad-spectrum antibiotics that may be used in the treatment of many common infections in children and adults. One of the side-effects of tetracyclines is incorporation into tissues that are calcifying at the time of their administration. They have the ability to chelate calcium ions and to be incorporated into teeth, cartilage and bone, resulting in discoloration of both the primary and permanent dentitions. This permanent discoloration varies from yellow or gray to brown depending on the dose or the type of the drug received in relation to body weight. Minocycline hydrochloride, a semisynthetic derivative of tetracycline often used for the treatment of acne, has been shown to cause pigmentation of a variety of tissues including skin, thyroid, nails, sclera, teeth, conjunctiva and bone. Adult-onset tooth discoloration following long-term ingestion of tetracycline and minocycline has also been reported. The remarkable side-effect of minocycline on the oral cavity is the singular occurrence of “black bones”, “black or green roots” and blue-gray to gray hue darkening of the crowns of permanent teeth. The prevalence of tetracycline and minocycline staining is 3–6%. The mechanism of minocycline staining is still unknown. Most of the reviewed literature consisted of case reports; longitudinal clinical trials are necessary to provide more information on the prevalence, severity, etiology and clinical presentation of tetracycline and TCN-derivative staining in the adult population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4632.2004.02108.x
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  • 5
    Electronic Resource
    Electronic Resource
    Current and elevated levels of UV-B radiation have few impacts on yields of perennial forage crops (1999)
    Oxford, UK : Blackwell Science Ltd
    Global change biology 5 (1999), S. 0 
    Details
    ISSN: 1365-2486
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Energy, Environment Protection, Nuclear Power Engineering , Geography
    Notes: Two experiments assessed the effect of current and elevated levels of ultravioletB (UV-B) radiation on forage crop production. The effect of current levels of UV-B radiation was assessed by comparing the growth of eight cultivars of four legume and four grass species for three growing seasons (1994–96) under simulated sward conditions in the field. An exclusion system using cellulose diacetate or polyester covers provided comparable growing conditions for the plants, except for the presence or absence of ambient UV-B radiation, respectively. The second experiment studied the effect of elevated levels of UV-B on eight cultivars of two legume and two grass species in the greenhouse under simulated sward conditions. Natural lighting with sufficient supplemental light was used to provide ideal growing conditions for a 16-h day length. Separate sets of UV lights were installed to provide UV-B levels at approximately the same intensity as would be found in mid summer, and 33% and 66% more than this value. A fourth treatment consisted of removing UV-B radiation by using a polyester filter. Plant production was measured in both experiments. In 1994, field herbage yields from all young grass and legume seedlings were not significantly affected by the exclusion of ambient UV-B radiation, with the exception of alfalfa. Intra-specific variations with alfalfa yields were found for reduced levels of UV-B radiation. In general, these trends persisted as stands matured during two post seeding years. In the second experiment, no significant differences were observed for all tested species with increasing levels of UV-B radiation, except with some alfalfa cultivars and one birdsfoot trefoil cultivar. Collectively, these results demonstrate that in the northern latitudes young and mature plants of the studied species are resistant to current and potentially higher levels of solar UV-B radiation, with the exception of some alfalfa cultivars. The yield of these cultivars increased under enhanced levels of UV-B radiation in the greenhouse and decreased when UV-B was excluded in the field.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2486.1999.00271.x
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  • 6
    Electronic Resource
    Electronic Resource
    2',4'-Dihydroxy-2-[3-(4-methylphenyl)isoxazol-5-yl]acetophenone (1998)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 54 (1998), S. 1123-1125 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270198003102
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  • 7
    Electronic Resource
    Electronic Resource
    Multiple small-angle scattering: an experimental investigation (1993)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 26 (1993), S. 357-362 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: The results of multiple small-angle neutron scattering (SANS) experiments carried out using a low-resolution instrument on two bidisperse Al2O3 samples, with particle sizes much larger than the limit accessible under the single-scattering approximation, have been analyzed in the light of a recently developed formalism for multiple small-angle scattering. It is shown that the extraction of realistic structural parameters that are in good agreement with those calculated from prior knowledge of the samples is only possible when both multiple scattering and bidispersity of the samples have been accounted for.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889892011063
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  • 8
    Electronic Resource
    Electronic Resource
    Identification of an Al–Ni–O precipitate in combustion-synthesized NiAl (2000)
    Copenhagen : International Union of Crystallography (IUCr)
    Applied crystallography online 33 (2000), S. 1217-1222 
    Details
    ISSN: 1600-5767
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Geosciences , Physics
    Notes: The complete identity of a second-phase precipitate detected by transmission electron microscopy in combustion-synthesized NiAl was established. The crystal structure, including the point group, the space group and the lattice parameters, was determined by convergent and selected-area electron diffraction techniques. Energy dispersive X-ray spectroscopy was used for the determination of the chemical composition. Analysis established the phase to be the solid solution of NiO in Al2O3 and presented evidence of the hitherto unreported room-temperature solubility.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0021889800008505
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  • 9
    Electronic Resource
    Electronic Resource
    A Key Intermediate in the Synthesis of Pentamidine: 4,4'-[1,5-Pentanediylbis(oxy)]bisbenzonitrile (1996)
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 52 (1996), S. 403-405 
    Details
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The title compound, C19H18N2O2, has an extended conformation at the central pentanediyl chain. The molecule has approximate twofold symmetry through atom C(9). The dihedral angle between the end-to-end phenyl rings is 1.3 (1)°, indicating the overall planarity of the molecule. This facilitates stacking of the phenyl rings in the crystal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S0108270195011966
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  • 10
    Electronic Resource
    Electronic Resource
    The validity of form-factor, modified-form-factor and anomalous-scattering-factor approximations in elastic scattering calculations (1995)
    [S.l.] : International Union of Crystallography (IUCr)
    Acta crystallographica 51 (1995), S. 271-288 
    Details
    ISSN: 1600-5724
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: The validity of form-factor, modified-form-factor and anomalous-scattering-factor approximations in predictions of elastic photon-atom scattering is assessed with the aid of the state-of-the-art numerical calculation of Rayleigh scattering obtained using the second-order S-matrix theory, in the photon energy range from 100 eV to 1 MeV. A comparison is made with predictions from S-matrix theory in the same atomic model for representative low-Z (carbon, Z = 6) and high-Z (lead, Z = 82) elements to get a general idea of the validity of these simpler more approximate methods. The importance of bound–bound contributions and the angle dependence of the anomalous scattering factors is discussed. A prescription is suggested, with the assumption of angle independence, that uses simpler approaches to obtain the elastic scattering cross sections in the soft-X-ray regime at the level of accuracy of the S-matrix calculation, failing at large momentum transfers for high-Z elements. Predictions from this prescription are compared with experiment. With starting point the many-body elastic scattering amplitude, a detailed discussion is presented of the partition of the elastic scattering amplitude into Rayleigh and Delbrück scattering components. This partition of the optical theorem reveals contributions from bound–bound atomic transitions, bound pair annihilation and bound pair production that are not usually associated with elastic scattering. In the partitioned optical theorem for Rayleigh scattering, as in the many-body optical theorem for scattering from excited states, subtracted cross sections naturally appear. These terms are needed, in addition to the familiar terms for photoionization, to relate the real and imaginary parts of the scattering amplitude.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/S010876739400886X
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