GLORIA

GEOMAR Library Ocean Research Information Access

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Description / Table of Contents: This fascinating and unique history of the Oxford Chemistry School shows how the University and individuals have advanced chemistry, This fascinating and unique history reveals the major influence of the Oxford Chemistry School on the advancement of chemistry. It shows how the nature of the University, and individuals within it, have shaped the school and made great achievements both in teaching and research. The book will appeal to those interested in the history of science and education, the city of Oxford and chemistry in general. Chemistry has been studied in Oxford for centuries but this book focuses on the last 400 years and, in particular, the seminal work of Robert Boyle, Robert Hooke, and the proto- Royal Society of the 1650's. Arranged in chronological fashion, it includes specialist studies of particular areas of innovation. The book shows that chemistry has advanced, not just as a consequence of research but, because of the idiosynchratic nature of the collegiate system and the characters of the individuals involved. In other words, it demonstrates that science is a human endeavour and its advance in any institution is conditioned by the organization and people within it. For chemists, the main appeal will be the book's examination of the way separate branches of chemistry (organic, physical, inorganic and biological) have evolved in Oxford. It also enables comparison with the development of the subject at other universities such as Cambridge, London and Manchester. For historians and sociologists, the book reveals the motivations of both scientists and non-scientists in the management of the School. It exposes the unusual character of Oxford University and the tensions between science and administration. The desire of the college to retain its academic values in the face of external and financial pressures is emphasized
    Type of Medium: Online Resource
    Pages: 318 p , Online-Ressource , 20 b&w, ill
    Edition: RSC eBook Collection 1968-2009
    Language: English
    Note: Ebook , Chapter 1: An Outline of the History of the University of Oxford with Reference to its Chemistry School-- Chapter 2: From Alchemy to Air Pumps: the Foundation of Oxford Chemistry to 1700-- Chapter 3: The Eighteenth Century: Chemistry Allied to Anatomy-- Chapter 4: Chemistry Comes of Age: the 19th Century-- Chapter 5: Research as the Thing: Oxford Chemistry 1912-1939-- Chapter 6: Interlude: Chemists at War-- Chapter 7: Recent Times 1945-2005: a School of World Renown.
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Interleukin (IL)-1β plays an important role in the inflammatory response that results from traumatic brain injury and antagonism of the actions of this cytokine can affect outcome. We subjected male mice to aseptic cryogenic injury and assessed recovery through anatomical, histological and functional measures following treatment with recombinant mouse IL-1 receptor antagonist (IL-1ra). A single dose (1 µg, i.c.v.) at the time of injury reduced lesion volume 3 days later, as assessed by Nissl staining, and also the number (30%) of FluoroJade-positive degenerating neurones. Mice treated with IL-1ra performed better on the beam balance and in the grid test as compared with vehicle-treated animals. Furthermore, IL-1ra-treated animals showed fewer (40%) nitric oxide synthase-2-positive cells in and around the lesion. These data suggest that activation of the IL-1 receptor following trauma contributes to the pathology and that antagonism can reduce both anatomical and functional consequences of neuroinflammation.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Previous studies suggest that progesterone may possess neuroprotective properties after traumatic insult but, with the exception of reduced formation of cerebral oedema, limited experimental evidence has been presented to support this claim. In the present study we focused on the effect of progesterone treatment on structural and functional deficits in an experimental model of traumatic brain injury. Female mice exhibited significantly (P = 0.0445) reduced lesion volumes compared with males after aseptic cryogenic cerebral injury (ACI), suggesting that female sex steroids provide protection against this injury. In male mice, progesterone treatment after injury (three intraperitoneal doses of 8 mg/kg) reduced lesion volume (P = 0.0429) and improved performance in a spatial cognitive task (Morris water maze; P = 0.0014). However, progesterone had no demonstrable effect on the formation of oedema as measured using T2-weighted magnetic resonance imaging, nor did it affect brain water content. The pro-inflammatory cytokines TNF-α and IL-1β, and growth factors BDNF and G-CSF, were all strongly transcriptionally activated after ACI. However, progesterone administration did not affect expression of these genes. This study provides strong evidence that progesterone possesses neuroprotective properties in a mouse model of traumatic brain injury, but suggests that the steroid achieves this effect through mechanism(s) independent of the inflammatory response or growth factor up-regulation.
    Type of Medium: Electronic Resource
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...