Electronic Resource
350 Main Street , Malden , MA 02148 , USA , and 9600 Garsington Road , Oxford OX4 2XG , UK .
:
Blackwell Science Inc
Journal of cardiovascular electrophysiology
15 (2004), S. 0
ISSN:
1540-8167
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The endothelium plays a vital role in the control of vascular functions, including modulation of tone; permeability and barrier properties; platelet adhesion and aggregation; and secretion of paracrine factors. Critical signaling events in many of these functions involve an increase in intracellular free Ca2+ concentration ([Ca2+]i). This rise in [Ca2+]i occurs via an interplay between several mechanisms, including release from intracellular stores, entry from the extracellular space through store depletion and second messenger-mediated processes, and the establishment of a favorable electrochemical gradient. The focus of this review centers on the role of potassium channels and membrane potential in the creation of a favorable electrochemical gradient for Ca2+ entry. In addition, evidence is examined for the existence of various classes of potassium channels and the possible influence of regional variation in expression and experimental conditions. (J Cardiovasc Electrophysiol, Vol. 15, pp. 598-610, May 2004)
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1046/j.1540-8167.2004.03277.x
Permalink
|
Location |
Call Number |
Limitation |
Availability |