ISSN:
1542-474X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Kawasaki disease (KD) is complicated by coronary artery abnormalities (CAA) in 3%-25% of patients, depending on acute therapy. ECG markers of ventricular vulnerability such as QT and JT dispersion, SAECG, and ambulatory monitoring have been shown to have predictive value in disparate diseases such as long QT syndrome, postmyocardial infarction, and atherosclerotic coronary artery disease. The aim of this study was to evaluate the association between QT and JT dispersion and the occurrence of CAA in KD.〈section xml:id="abs1-2"〉〈title type="main"〉MethodsOver the past 15 years, we evaluated 814 children with acute KD, of which 24 (3%) developed significant CAA (aneurysms, stenoses). An additional 40 children (5%) developed milder CAA (4–5 mm dilation). Multivariate analysis was used to compare QTc, JTc, and dispersion in the 24 patients who developed significant CAA with three other groups: 40 patients with mild CAA, 750 KD patients without evidence of CAA, and 1000 normal control children. A small prospective study included additional noninvasive ECG markers using ambulatory (Holter) monitoring and SAECG.〈section xml:id="abs1-3"〉〈title type="main"〉ResultsThere were no significant differences in any ECG measures of ventricular repolarization among any of the three KD groups and the normal control pediatric ECGs.〈section xml:id="abs1-4"〉〈title type="main"〉ConclusionsIncreased dispersion of ventricular repolarization is not associated with coronary-artery abnormalities in KD.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1542-474X.1998.tb00042.x
Permalink