ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Vanilloid receptor I (TRPV1) is an integral membrane protein that integrates thermal and chemical stimuli. This molecular device is at the essence of cellular signalling at peripheral nerve terminals where it plays a central role in nociception. As expected, channel dysfunction is critically involved in pain transduction, specially in inflammatory pain. This notion is supported by genetic and pharmacological knock out data. As other ion channels, TRPV1 is a component of supramolecular assemblies that configure intraneuronal protein networks essential for signal transduction. As a result, a tremendous effort is being invested to identify the molecular components of the ion channel complex, and to validate them as therapeutic targets for better analgesic drugs. Current advances and discoveries in this exciting field will be highlighted, along with their implications for efficient and selective pain management.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1046/j.1471-4159.85.s2.4_2.x
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